Stn1 MGI Mouse Gene Detail - MGI:1915581 - STN1, CST complex subunit

Symbol

Stn1
Name

STN1, CST complex subunit
Synonyms

0610009H20Rik, 2310057J23Rik, Obfc1

Feature Type

protein coding gene
IDs

MGI:1915581
NCBI Gene: 108689
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr19:47489472-47525946 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 39.64 cM
Mapping Data

2 experiments

SNPs within 2kb

1405 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915581	protein coding gene	Chr19:47489470-47534284 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0025230	protein coding gene	Chr19:47321193-47357785 (-)
A/J	MGP_AJ_G0025206	protein coding gene	Chr19:44948735-44985726 (-)
AKR/J	MGP_AKRJ_G0025175	protein coding gene	Chr19:46415087-46456474 (-)
BALB/cJ	MGP_BALBcJ_G0025201	protein coding gene	Chr19:45004348-45040938 (-)
C3H/HeJ	MGP_C3HHeJ_G0024961	protein coding gene	Chr19:46599838-46638949 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0025644	protein coding gene	Chr19:48448588-48488625 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023057	protein coding gene	Chr19:44179933-44217199 (-)
CAST/EiJ	MGP_CASTEiJ_G0024426	protein coding gene	Chr19:46424525-46462321 (-)
CBA/J	MGP_CBAJ_G0024941	protein coding gene	Chr19:50899258-50955104 (-)
DBA/2J	MGP_DBA2J_G0025073	protein coding gene	Chr19:44756682-44795151 (-)
FVB/NJ	MGP_FVBNJ_G0025034	protein coding gene	Chr19:44556926-44593660 (-)
LP/J	MGP_LPJ_G0025159	protein coding gene	Chr19:47211869-47252420 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025065	protein coding gene	Chr19:50156911-50198987 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025702	protein coding gene	Chr19:46534926-46572193 (-)
PWK/PhJ	MGP_PWKPhJ_G0024175	protein coding gene	Chr19:44731509-44770641 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0023978	protein coding gene	Chr19:45190230-45230162 (-)
WSB/EiJ	MGP_WSBEiJ_G0024496	protein coding gene	Chr19:46691354-46730507 (-)

Human Ortholog

STN1, STN1 subunit of CST complex

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

STN1, STN1 subunit of CST complex
Synonyms

AAF-44, AAF44, bA541N10.2, OBFC1, RPA-32
Links

HGNC:26200

NCBI Gene ID: 79991

neXtProt AC: NX_Q9H668

UniProt: Q9H668
Chr Location

10q24.33; chr10:103856806-103918332 (-) GRCh38

MGI Vertebrate Homology

Stn1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: STN1
Protein SuperFamily

UCP036950
Gene Tree

Stn1

Diseases

1 with human STN1 associations

				Human Disease	Mouse Models
				melanoma IDs melanoma DOID:1909 EFO:0000756 KEGG:05218 MESH:D008545 NCI:C3224 UMLS_CUI:C0025202

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

4 phenotype references

All Mutations and Alleles

9
Gene trapped

9
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

10 strains or lines available

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All GO Annotations

31
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

10

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase stn1

ZFIN stn1

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All Sequences

58
RefSeq

6
UniProt

6
CCDS

CCDS29892.1

Ensembl

ENSMUSG00000042694 (Evidence)
NCBI Gene

108689

			Length	Strain/Species	Flank
genomic	ENSMUSG00000042694	Ensembl Gene Model \| MGI Sequence Detail	36475	C57BL/6J	± kb
transcript	ENSMUST00000049369	Ensembl \| MGI Sequence Detail	1992	Not Applicable
polypeptide	ENSMUSP00000040944	Ensembl \| MGI Sequence Detail	378	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000011582 oligonucleotide/oligosaccharide-binding fold-containing protein 1

(term hierarchy)
PDB

1WJ5
InterPro Domains

IPR014647 CST complex subunit Stn1

IPR018856 CST complex subunit Stn1, N-terminal

IPR042082 CST complex subunit Stn1, wHTH1 motif superfamily

IPR012340 Nucleic acid-binding, OB-fold

IPR040260 Replication factor A protein-like

IPR015253 Stn1, C-terminal

IPR036390 Winged helix DNA-binding domain superfamily

IPR036388 Winged helix-like DNA-binding domain superfamily

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All nucleic 10

cDNA 10

Microarray probesets 4

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MGI:1916898, MGI:2147515

Summaries

All 32

Gene Ontology 8

Phenotypes 4
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:335558 Nguyen DD, et al., Deficiency in mammalian STN1 promotes colon cancer development via inhibiting DNA repair. Sci Adv. 2023 May 10;9(19):eadd8023

TSS for Stn1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr159739	Chr19:47525436-47525488 (-)	484 bp
Tssr159738	Chr19:47497199-47497216 (-)	28,738 bp
Tssr159737	Chr19:47496333-47496351 (-)	29,604 bp
Tssr159736	Chr19:47496312-47496332 (-)	29,624 bp
Tssr159735	Chr19:47496289-47496296 (-)	29,653 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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