G6pc3 MGI Mouse Gene Detail - MGI:1915651 - glucose 6 phosphatase, catalytic, 3

Symbol

G6pc3
Name

glucose 6 phosphatase, catalytic, 3
Synonyms

0710001K01Rik

Feature Type

protein coding gene
IDs

MGI:1915651
NCBI Gene: 68401
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr11:102080525-102084907 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 65.79 cM
Mapping Data

2 experiments

SNPs within 2kb

151 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915651	protein coding gene	Chr11:102080446-102084907 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019225	protein coding gene	Chr11:105142303-105146754 (+)
A/J	MGP_AJ_G0019193	protein coding gene	Chr11:100703456-100707917 (+)
AKR/J	MGP_AKRJ_G0019162	protein coding gene	Chr11:103823095-103827546 (+)
BALB/cJ	MGP_BALBcJ_G0019167	protein coding gene	Chr11:101191593-101196044 (+)
C3H/HeJ	MGP_C3HHeJ_G0018976	protein coding gene	Chr11:104024645-104029096 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019616	protein coding gene	Chr11:108415819-108422673 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017242	protein coding gene	Chr11:98133226-98137737 (+)
CAST/EiJ	MGP_CASTEiJ_G0018530	protein coding gene	Chr11:104999326-105003802 (+)
CBA/J	MGP_CBAJ_G0018945	protein coding gene	Chr11:112890159-112894583 (+)
DBA/2J	MGP_DBA2J_G0019057	protein coding gene	Chr11:100227694-100232146 (+)
FVB/NJ	MGP_FVBNJ_G0019047	protein coding gene	Chr11:99755900-99760354 (+)
LP/J	MGP_LPJ_G0019126	protein coding gene	Chr11:105664066-105668547 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019078	protein coding gene	Chr11:112413466-112417966 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019654	protein coding gene	Chr11:104182826-104187274 (+)
PWK/PhJ	MGP_PWKPhJ_G0018293	protein coding gene	Chr11:101289754-101294292 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018085	protein coding gene	Chr11:103939626-103944849 (+)
WSB/EiJ	MGP_WSBEiJ_G0018579	protein coding gene	Chr11:104175621-104180071 (+)

Human Ortholog

G6PC3, glucose-6-phosphatase catalytic subunit 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

G6PC3, glucose-6-phosphatase catalytic subunit 3
Synonyms

SCN4, UGRP
Links

HGNC:24861

NCBI Gene ID: 92579

neXtProt AC: NX_Q9BUM1

UniProt: Q9BUM1
Chr Location

17q21.31; chr17:44070620-44082151 (+) GRCh38

MGI Vertebrate Homology

G6pc3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: G6PC3
Protein SuperFamily

Glucose-6-phosphatase
Gene Tree

G6pc3

Diseases

1 with human G6PC3 associations

				Human Disease	Mouse Models
				severe congenital neutropenia 4 IDs severe congenital neutropenia 4 DOID:0112136 OMIM:612541 ORDO:331176

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

12 phenotypes from 2 alleles in 2 genetic backgrounds
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

2
Targeted

6
Genomic Mutations

1 involving G6pc3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

12 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutation of this gene results in females, but not males, that are growth retarded and weight less and exhibit elevated plasma glucagon levels but lowered plasma cholesterols after fasting.

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All GO Annotations

17
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

847
Tissues

100
cDNA Data

59
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase g6pc3

ZFIN g6pc3

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All Sequences

46
RefSeq

2
UniProt

1
CCDS

CCDS25491.1

Ensembl

ENSMUSG00000034793 (Evidence)
NCBI Gene

68401

			Length	Strain/Species	Flank
genomic	68401	NCBI Gene Model \| MGI Sequence Detail	4383	C57BL/6J	± kb
transcript	NM_175935	RefSeq \| MGI Sequence Detail	1612	FVB/N
polypeptide	Q6NSQ9	UniProt \| EBI \| MGI Sequence Detail	346	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000007748 glucose-6-phosphatase 3

(term hierarchy)
EC

3.1.3.9
InterPro Domains

IPR016275 Glucose-6-phosphatase

IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase

IPR036938 Phosphatidic acid phosphatase type 2/haloperoxidase superfamily

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All nucleic 61

Genomic 1

cDNA 59

Primer pair 1

Microarray probesets 3

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MGI:2144389, MGI:2144442, MGI:2144461, MGI:2144559

Summaries

All 50

Developmental Gene Expression 5

Gene Ontology 8

Phenotypes 17
Earliest

J:56548 Zheng B, et al., Engineering a mouse balancer chromosome. Nat Genet. 1999 Aug;22(4):375-8
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for G6pc3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr105192	Chr11:102080477-102080560 (+)	-6 bp
Tssr105193	Chr11:102080596-102080617 (+)	82 bp
Tssr105194	Chr11:102080636-102080659 (+)	123 bp
Tssr105195	Chr11:102080666-102080696 (+)	156 bp
Tssr105196	Chr11:102083183-102083210 (+)	2,672 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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