Lrrc28 MGI Mouse Gene Detail - MGI:1915689 - leucine rich repeat containing 28

Symbol

Lrrc28
Name

leucine rich repeat containing 28
Synonyms

1300004K21Rik, 2210012C09Rik, 2310058O11Rik

Feature Type

protein coding gene
IDs

MGI:1915689
NCBI Gene: 67867
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr7:67163158-67295016 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 37.05 cM, cytoband C
Mapping Data

2 experiments

SNPs within 2kb

3934 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915689	protein coding gene	Chr7:67163158-67295084 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0032359	protein coding gene	Chr7:68769169-68911588 (-)
A/J	MGP_AJ_G0032338	protein coding gene	Chr7:67354645-67487054 (-)
AKR/J	MGP_AKRJ_G0032274	protein coding gene	Chr7:68776295-68914931 (-)
BALB/cJ	MGP_BALBcJ_G0032350	protein coding gene	Chr7:67092208-67222914 (-)
C3H/HeJ	MGP_C3HHeJ_G0032063	protein coding gene	Chr7:69466023-69600854 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0032842	protein coding gene	Chr7:71725937-71861157 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029849	protein coding gene	Chr7:70214098-70345075 (-)
CAST/EiJ	MGP_CASTEiJ_G0031391	protein coding gene	Chr7:60164488-60297942 (-)
CBA/J	MGP_CBAJ_G0032029	protein coding gene	Chr7:73960904-74103479 (-)
DBA/2J	MGP_DBA2J_G0032184	protein coding gene	Chr7:66074859-66204440 (-)
FVB/NJ	MGP_FVBNJ_G0032139	protein coding gene	Chr7:66190221-66320827 (-)
LP/J	MGP_LPJ_G0032265	protein coding gene	Chr7:70000800-70133389 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032176	protein coding gene	Chr7:74181742-74321060 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032860	protein coding gene	Chr7:68145344-68278337 (-)
PWK/PhJ	MGP_PWKPhJ_G0031111	protein coding gene	Chr7:59123306-59257751 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0030952	protein coding gene	Chr7:55185538-55325577 (-)
WSB/EiJ	MGP_WSBEiJ_G0031509	protein coding gene	Chr7:68478798-68619310 (-)

Human Ortholog

LRRC28, leucine rich repeat containing 28

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LRRC28, leucine rich repeat containing 28
Links

HGNC:28355

NCBI Gene ID: 123355

neXtProt AC: NX_Q86X40

UniProt: Q86X40
Chr Location

15q26.3; chr15:99251362-99390729 (+) GRCh38

MGI Vertebrate Homology

Lrrc28 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: LRRC28
Gene Tree

Lrrc28

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

7
Radiation induced

1
Genomic Mutations

2 involving Lrrc28
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

27 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

1
GO References

1

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

47
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase lrrc28

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All Sequences

83
RefSeq

18
UniProt

8
CCDS

CCDS21351.1, CCDS52269.1

Ensembl

ENSMUSG00000030556 (Evidence)
NCBI Gene

67867

			Length	Strain/Species	Flank
genomic	ENSMUSG00000030556	Ensembl Gene Model \| MGI Sequence Detail	131859	C57BL/6J	± kb
transcript	ENSMUST00000053950	Ensembl \| MGI Sequence Detail	2923	Not Applicable
polypeptide	ENSMUSP00000052177	Ensembl \| MGI Sequence Detail	367	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000031340 leucine-rich repeat-containing protein 28

(term hierarchy)
InterPro Domains

IPR001611 Leucine-rich repeat

IPR050216 Leucine-rich repeat domain-containing protein

IPR032675 Leucine-rich repeat domain superfamily

IPR003591 Leucine-rich repeat, typical subtype

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All nucleic 47

cDNA 47

Microarray probesets 6

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MGI:1915117, MGI:1917638

Summaries

All 35

Developmental Gene Expression 1

Gene Ontology 1

Phenotypes 14
Earliest

J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
Latest

J:284228 Ikegami K, et al., Effect of expression alteration in flanking genes on phenotypes of St8sia2-deficient mice. Sci Rep. 2019 Sep 20;9(1):13634

TSS for Lrrc28:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr72858	Chr7:67295028-67295080 (-)	-38 bp
Tssr72857	Chr7:67294943-67295021 (-)	34 bp
Tssr72856	Chr7:67269764-67269776 (-)	25,246 bp
Tssr72855	Chr7:67269725-67269745 (-)	25,281 bp
Tssr72854	Chr7:67178721-67178744 (-)	116,283 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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