Rraga MGI Mouse Gene Detail - MGI:1915691 - Ras-related GTP binding A

Symbol

Rraga
Name

Ras-related GTP binding A
Synonyms

1300010C19Rik, FIP-1

Feature Type

protein coding gene
IDs

MGI:1915691
NCBI Gene: 68441
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr4:86493910-86495522 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 40.69 cM
Mapping Data

3 experiments

SNPs within 2kb

91 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915691	protein coding gene	Chr4:86493905-86495522 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028411	protein coding gene	Chr4:86338250-86339867 (+)
A/J	MGP_AJ_G0028372	protein coding gene	Chr4:83330925-83332543 (+)
AKR/J	MGP_AKRJ_G0028321	protein coding gene	Chr4:85430137-85431754 (+)
BALB/cJ	MGP_BALBcJ_G0028392	protein coding gene	Chr4:83514082-83515700 (+)
C3H/HeJ	MGP_C3HHeJ_G0028107	protein coding gene	Chr4:86078990-86080608 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028831	protein coding gene	Chr4:89609861-89611479 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026131	protein coding gene	Chr4:79424458-79426067 (+)
CAST/EiJ	MGP_CASTEiJ_G0027548	protein coding gene	Chr4:83982615-83984232 (+)
CBA/J	MGP_CBAJ_G0028076	protein coding gene	Chr4:92396787-92398405 (+)
DBA/2J	MGP_DBA2J_G0028225	protein coding gene	Chr4:83074806-83076423 (+)
FVB/NJ	MGP_FVBNJ_G0028191	protein coding gene	Chr4:82062640-82064257 (+)
LP/J	MGP_LPJ_G0028325	protein coding gene	Chr4:86673329-86674946 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028220	protein coding gene	Chr4:97450215-97451832 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028868	protein coding gene	Chr4:85503901-85505519 (+)
PWK/PhJ	MGP_PWKPhJ_G0027271	protein coding gene	Chr4:81420108-81421723 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027096	protein coding gene	Chr4:83056648-83058275 (+)
WSB/EiJ	MGP_WSBEiJ_G0027624	protein coding gene	Chr4:85688221-85689837 (+)

Human Ortholog

RRAGA, Ras related GTP binding A

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RRAGA, Ras related GTP binding A
Synonyms

FIP-1, FIP1, RAGA
Links

HGNC:16963

NCBI Gene ID: 10670

neXtProt AC: NX_Q7L523

UniProt: Q7L523
Chr Location

9p22.1; chr9:19049427-19051025 (+) GRCh38

MGI Vertebrate Homology

Rraga stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RRAGA
Gene Tree

Rraga

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Phenotype Summary

23 phenotypes from 4 alleles in 5 genetic backgrounds
21 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Chemically induced (other)

2
Endonuclease-mediated

4
Gene trapped

2
Radiation induced

1
Targeted

5
Genomic Mutations

5 involving Rraga
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

17 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for null mutations display embryonic lethality during organogenesis, impaired growth and open neural tubes. Mice homozygous for a constitutively active knock-in allele exhibit neonatal lethality associated with impaired hepatic gluconeogenesis and impaired autophagy.

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All GO Annotations

69
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

717
Tissues

7
cDNA Data

69
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rraga

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All Sequences

33
RefSeq

2
UniProt

1
CCDS

CCDS18306.1

Ensembl

ENSMUSG00000070934 (Evidence)
NCBI Gene

68441

			Length	Strain/Species	Flank
genomic	68441	NCBI Gene Model \| MGI Sequence Detail	1613	C57BL/6J	± kb
transcript	NM_178376	RefSeq \| MGI Sequence Detail	1653	C57BL/6
polypeptide	Q80X95	UniProt \| EBI \| MGI Sequence Detail	313	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000014297 Ras-related GTP-binding protein A

(term hierarchy)
EC

3.6.5.-
InterPro Domains

IPR006762 Gtr1/RagA G protein

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR039397 RagA/B

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All nucleic 70

cDNA 70

Microarray probesets 2

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MGI:2140212

Summaries

All 57

Developmental Gene Expression 1

Gene Ontology 10

Phenotypes 21
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:349365 Samson N, et al., HSDL2 links nutritional cues to bile acid and cholesterol homeostasis. Sci Adv. 2024 May 31;10(22):eadk9681

TSS for Rraga:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr37728	Chr4:86493905-86493926 (+)	6 bp
Tssr37729	Chr4:86493933-86493955 (+)	34 bp
Tssr37730	Chr4:86493957-86493968 (+)	53 bp
Tssr37731	Chr4:86493977-86493988 (+)	73 bp
Tssr37732	Chr4:86494020-86494031 (+)	116 bp
Tssr37733	Chr4:86494033-86494044 (+)	129 bp
Tssr37734	Chr4:86495147-86495158 (+)	1,243 bp
Tssr37735	Chr4:86495340-86495353 (+)	1,437 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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