Gpihbp1 MGI Mouse Gene Detail - MGI:1915703 - GPI-anchored HDL-binding protein 1

Symbol

Gpihbp1
Name

GPI-anchored HDL-binding protein 1
Synonyms

1110002J19Rik, GPI-HBP1

Feature Type

protein coding gene
IDs

MGI:1915703
NCBI Gene: 68453
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr15:75468479-75470062 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 34.59 cM, cytoband E1
Mapping Data

3 experiments

SNPs within 2kb

120 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915703	protein coding gene	Chr15:75468477-75471330 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021954	protein coding gene	Chr15:75619421-75622274 (+)
A/J	MGP_AJ_G0021912	protein coding gene	Chr15:72873564-72880238 (+)
AKR/J	MGP_AKRJ_G0021895	protein coding gene	Chr15:74837018-74839871 (+)
BALB/cJ	MGP_BALBcJ_G0021921	protein coding gene	Chr15:72890677-72893530 (+)
C3H/HeJ	MGP_C3HHeJ_G0021693	protein coding gene	Chr15:74903433-74906286 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022361	protein coding gene	Chr15:78455533-78458386 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019892	protein coding gene	Chr15:69552785-69555634 (+)
CAST/EiJ	MGP_CASTEiJ_G0021212	protein coding gene	Chr15:75675450-75679829 (+)
CBA/J	MGP_CBAJ_G0021660	protein coding gene	Chr15:80971948-80974801 (+)
DBA/2J	MGP_DBA2J_G0021785	protein coding gene	Chr15:72391452-72394305 (+)
FVB/NJ	MGP_FVBNJ_G0021766	protein coding gene	Chr15:71446612-71449465 (+)
LP/J	MGP_LPJ_G0021856	protein coding gene	Chr15:75712085-75714938 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021790	protein coding gene	Chr15:86258112-86260965 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022381	protein coding gene	Chr15:75085041-75091710 (+)
PWK/PhJ	MGP_PWKPhJ_G0020953	protein coding gene	Chr15:72527037-72529888 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020792	protein coding gene	Chr15:74816427-74819278 (+)
WSB/EiJ	MGP_WSBEiJ_G0021264	protein coding gene	Chr15:75172417-75175270 (+)

Human Ortholog

GPIHBP1, glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GPIHBP1, glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1
Synonyms

GPI-HBP1, HYPL1D
Links

HGNC:24945

NCBI Gene ID: 338328

neXtProt AC: NX_Q8IV16

UniProt: Q8IV16
Chr Location

8q24.3; chr8:143213218-143217170 (+) GRCh38

MGI Vertebrate Homology

Gpihbp1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: GPIHBP1
Gene Tree

Gpihbp1

Diseases

1 with human GPIHBP1 associations

				Human Disease	Mouse Models
				familial GPIHBP1 deficiency IDs familial GPIHBP1 deficiency DOID:0111420 OMIM:615947 ORDO:535458

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
59 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Chemically induced (other)

3
Endonuclease-mediated

3
Radiation induced

2
Targeted

5
Genomic Mutations

5 involving Gpihbp1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

20 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit milky plasma due to increased triglyceride and cholesterol levels.

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All GO Annotations

40
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

708
Tissues

1
cDNA Data

51
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

43
RefSeq

6
UniProt

3
CCDS

CCDS27545.1, CCDS84173.1, CCDS88781.1

Ensembl

ENSMUSG00000022579 (Evidence)
NCBI Gene

68453

			Length	Strain/Species	Flank
genomic	68453	NCBI Gene Model \| MGI Sequence Detail	1584	C57BL/6J	± kb
transcript	NM_026730	RefSeq \| MGI Sequence Detail	854	C57BL/6
polypeptide	Q9D1N2	UniProt \| EBI \| MGI Sequence Detail	228	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000008176 glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

(term hierarchy)
InterPro Domains

IPR018363 CD59 antigen, conserved site

IPR016054 Ly-6 antigen/uPA receptor-like

IPR051110 Ly-6/neurotoxin-like and GPI-anchored

IPR045860 Snake toxin-like superfamily
GlyGen

Q9D1N2 1 site

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All nucleic 51

cDNA 51

Microarray probesets 3

Summaries

All 94

Developmental Gene Expression 3

Diseases 1

Gene Ontology 7

Phenotypes 59
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:343428 Yang Y, et al., Hypertriglyceridemia in Apoa5-/- mice results from reduced amounts of lipoprotein lipase in the capillary lumen. J Clin Invest. 2023 Dec 1;133(23)

TSS for Gpihbp1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr131664	Chr15:75468473-75468492 (+)	4 bp
Tssr131665	Chr15:75468494-75468511 (+)	24 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24