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Nsmce2 Gene Detail
Summary
  • Symbol
    Nsmce2
  • Name
    NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase
  • Synonyms
    1110014D18Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915751
    NCBI Gene: 68501
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:59246096-59473533 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 25.19 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5113 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915751
 protein coding gene Chr15:59246047-59473538 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021884
 protein coding gene Chr15:58594541-58837341 (+)
A/J MGP_AJ_G0021844
 protein coding gene Chr15:56318155-56549558 (+)
AKR/J MGP_AKRJ_G0021825
 protein coding gene Chr15:57869336-58101192 (+)
BALB/cJ MGP_BALBcJ_G0021851
 protein coding gene Chr15:56529730-56755737 (+)
C3H/HeJ MGP_C3HHeJ_G0021625
 protein coding gene Chr15:57998863-58231242 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022290
 protein coding gene Chr15:60853591-61090348 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019827
 protein coding gene Chr15:53392350-53616218 (+)
CAST/EiJ MGP_CASTEiJ_G0021142
 protein coding gene Chr15:58682267-58920606 (+)
CBA/J MGP_CBAJ_G0021594
 protein coding gene Chr15:62985193-63233579 (+)
DBA/2J MGP_DBA2J_G0021718
 protein coding gene Chr15:56222915-56450698 (+)
FVB/NJ MGP_FVBNJ_G0021696
 protein coding gene Chr15:55272291-55508798 (+)
LP/J MGP_LPJ_G0021788
 protein coding gene Chr15:58462886-58703291 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021720
 protein coding gene Chr15:68023318-68266444 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022313
 protein coding gene Chr15:58271801-58509161 (+)
PWK/PhJ MGP_PWKPhJ_G0020887
 protein coding gene Chr15:56240049-56477761 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020724
 protein coding gene Chr15:58065126-58292882 (+)
WSB/EiJ MGP_WSBEiJ_G0021197
 protein coding gene Chr15:58284397-58515979 (+)



Homology
more
  • Human Ortholog
    NSMCE2, NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NSMCE2, NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase
  • Synonyms
    C8orf36, MMS21, NSE2, ZMIZ7
  • Links
    NCBI Gene ID: 286053
    neXtProt AC: NX_Q96MF7
    UniProt: Q96MF7

  • Chr Location
    8q24.13; chr8:125091679-125367120 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Nsmce2 mouse models; 1 with human NSMCE2 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    33 phenotypes from 4 alleles in 4 genetic backgrounds
    5 phenotypes from multigenic genotypes
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display early embryonic lethality. Heterozygous null mice display reduced lifespans with increased tumor formation. Homozygous and heterozygous null mice display impaired mitotic segregation and elevated mitotic recombination.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    712
  • Tissues
    4
  • cDNA Data
    87
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000059586 Ensembl Gene Model | MGI Sequence Detail 227438 C57BL/6J ±  kb
    transcript ENSMUST00000227173 Ensembl | MGI Sequence Detail 1122 Not Applicable  
    polypeptide ENSMUSP00000154811 Ensembl | MGI Sequence Detail 273 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 87
      cDNA 87

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2146050
    References
    more
    • Summaries
      All 67
      Developmental Gene Expression 3
      Diseases 2
      Gene Ontology 6
      Phenotypes 38
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory