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Tomm5 Gene Detail
Summary
  • Symbol
    Tomm5
  • Name
    translocase of outer mitochondrial membrane 5
  • Synonyms
    1110019J04Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915762
    NCBI Gene: 68512
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:45105209-45108113 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 23.72 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    151 from dbSNP Build 142
  • Strain Annotations
    9
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915762
 protein coding gene Chr4:45105208-45108114 (-)
129S1/SvImJ no annotation
A/J MGP_AJ_G0028198
 protein coding gene Chr4:41772589-41775507 (-)
AKR/J no annotation
BALB/cJ MGP_BALBcJ_G0028218
 protein coding gene Chr4:41855091-41857997 (-)
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0028659
 protein coding gene Chr4:44956838-44959748 (-)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0027379
 protein coding gene Chr4:42918651-42922278 (-)
CBA/J no annotation
DBA/2J MGP_DBA2J_G0028055
 protein coding gene Chr4:41670724-41673528 (-)
FVB/NJ MGP_FVBNJ_G0028022
 protein coding gene Chr4:40897548-40900754 (-)
LP/J MGP_LPJ_G0028154
 protein coding gene Chr4:43373507-43376412 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028046
 protein coding gene Chr4:49491211-49494591 (-)
NZO/HlLtJ no annotation
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    TOMM5, translocase of outer mitochondrial membrane 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TOMM5, translocase of outer mitochondrial membrane 5
  • Synonyms
    bA613M10.3, C9orf105, Tom5
  • Links
    NCBI Gene ID: 401505
    neXtProt AC: NX_Q8N4H5
    UniProt: Q8N4H5

  • Chr Location
    9p13.2
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele exhibit partial neonatal lethality, cryptogenic organizing pneumonia, intra-alveolar fibrosis, diffuse moderate eosinophilic granulocytosis in the bone marrow, and thymus atrophy.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    82
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 68512 NCBI Gene Model | MGI Sequence Detail 2905 C57BL/6J ±  kb
    transcript NM_001134646 RefSeq | MGI Sequence Detail 701 C57BL/6  
    polypeptide B1AXP6 UniProt | EBI | MGI Sequence Detail 51 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000033021 mitochondrial import receptor subunit TOM5 homolog
      (term hierarchy)
    • InterPro Domains
      IPR029179 Mitochondrial import receptor subunit TOM5, metazoa
      IPR019603 Mitochondrial outer membrane translocase complex, subunit Tom5
    Molecular
    Reagents
    less
    • All nucleic 82
      cDNA 82

      Microarray probesets 3
    References
    more
    • Summaries
      All 27
      Gene Ontology 6
      Phenotypes 3
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:186382 Vogel P, et al., Cryptogenic organizing pneumonia in Tomm5(-/-) mice. Vet Pathol. 2013 Jan;50(1):65-75
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory