Entrep3 Gene Detail

Summary

• Symbol
  Entrep3
• Name
  endosomal transmembrane epsin interactor 3
• Synonyms
  1110013L07Rik, Fam189b

• Feature Type
  protein coding gene
• IDs
  MGI:1915771
  NCBI Gene: 68521
• Alliance
  gene page
• Transcription Start Sites
  17 TSS

Location &
Maps

• Sequence Map
  Chr3:89090450-89096602 bp, + strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 3, 39.01 cM
• Mapping Data
  1 experiment

Strain
Comparison

• SNPs within 2kb
  182 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915771	protein coding gene	Chr3:89089996-89096602 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027420	protein coding gene	Chr3:89380681-89386786 (+)
A/J	MGP_AJ_G0027384	protein coding gene	Chr3:86421202-86427302 (+)
AKR/J	MGP_AKRJ_G0027348	protein coding gene	Chr3:88518412-88524555 (+)
BALB/cJ	MGP_BALBcJ_G0027393	protein coding gene	Chr3:86391981-86399023 (+)
C3H/HeJ	MGP_C3HHeJ_G0027135	protein coding gene	Chr3:88717719-88723821 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027839	protein coding gene	Chr3:92763459-92771160 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025191	protein coding gene	Chr3:81910569-81916683 (+)
CAST/EiJ	MGP_CASTEiJ_G0026581	protein coding gene	Chr3:89063261-89070408 (+)
CBA/J	MGP_CBAJ_G0027109	protein coding gene	Chr3:95942683-95952323 (+)
DBA/2J	MGP_DBA2J_G0027247	protein coding gene	Chr3:85807348-85813505 (+)
FVB/NJ	MGP_FVBNJ_G0027215	protein coding gene	Chr3:84147041-84153113 (+)
LP/J	MGP_LPJ_G0027356	protein coding gene	Chr3:90462658-90468786 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027235	protein coding gene	Chr3:102157843-102164806 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027898	protein coding gene	Chr3:88269793-88275897 (+)
PWK/PhJ	MGP_PWKPhJ_G0026315	protein coding gene	Chr3:85676967-85683348 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026134	protein coding gene	Chr3:87436260-87442420 (+)
WSB/EiJ	MGP_WSBEiJ_G0026663	protein coding gene	Chr3:88659302-88665293 (+)

Homology

• Human Ortholog
  ENTREP3, endosomal transmembrane epsin interactor 3

• Vertebrate Orthologs
  3

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  ENTREP3, endosomal transmembrane epsin interactor 3
  
• Synonyms
  C1orf2, COTE1, FAM189B
• Links
  HGNC:1233

  NCBI Gene ID: 10712

  neXtProt AC: NX_P81408

  UniProt: P81408

  
  
• Chr Location
  1q22; chr1:155247205-155255483 (-)  GRCh38

---

• MGI Vertebrate Homology
  Entrep3 stringent orthology
  1 human;1 mouse;1 rat;1 zebrafish
  
• HCOP
  vertebrate homology predictions: ENTREP3
• Gene Tree
  Entrep3
  

Human Diseases

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  8 phenotype references
  

• All Mutations and Alleles
  6
• Chemically induced (other)
  1
• Endonuclease-mediated
  1
• Gene trapped
  3
• Radiation induced
  1
• Genomic Mutations
  2 involving Entrep3
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  23 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  3
• GO References
  3

Expression

• Assay Results
  706
• cDNA Data
  40

Tissue x Stage Matrix

• Other Mouse Links
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase entrep3

Sequences &
Gene Models

• All Sequences
  72
• RefSeq
  23
• UniProt
  7
• CCDS
  CCDS17492.1

• Ensembl
  ENSMUSG00000032657 (Evidence)
• NCBI Gene
  68521

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000032657	Ensembl Gene Model | MGI Sequence Detail	6153	C57BL/6J
transcript	ENSMUST00000041913	Ensembl | MGI Sequence Detail	3083	Not Applicable
polypeptide	ENSMUSP00000039261	Ensembl | MGI Sequence Detail	669	Not Applicable

Protein
Information

• UniProt
  7 Sequences
• Protein Ontology
  PR:000030631 protein ENTREP3
  (term hierarchy)
• InterPro Domains
  IPR007237 CD20-like family
  IPR030431 Endosomal transmembrane epsin interactor 1-3
• GlyGen
  Q5HZJ5 1 site, 1 N-linked glycan (1 site)

Molecular
Reagents

• All nucleic 40

  cDNA 40

  
  

  Microarray probesets 3

Other
Accession IDs

MGI:7328928

References

• Summaries
  All 27

  Diseases 1

  Gene Ontology 3

  Phenotypes 8
• Earliest
  J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
• Latest
  J:302829 Lu J, et al., Mouse models for human hyperuricaemia: a critical review. Nat Rev Rheumatol. 2019 Jul;15(7):413-426

TSS for Entrep3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr30047	Chr3:89090438-89090514 (+)	26 bp
Tssr30048	Chr3:89090706-89090717 (+)	262 bp
Tssr30049	Chr3:89094019-89094028 (+)	3,574 bp
Tssr30050	Chr3:89094040-89094051 (+)	3,596 bp
Tssr30051	Chr3:89094053-89094064 (+)	3,609 bp
Tssr30052	Chr3:89094083-89094094 (+)	3,639 bp
Tssr30053	Chr3:89094670-89094682 (+)	4,226 bp
Tssr30054	Chr3:89094697-89094716 (+)	4,257 bp
Tssr30055	Chr3:89094738-89094764 (+)	4,301 bp
Tssr30056	Chr3:89094782-89094795 (+)	4,339 bp
Tssr30057	Chr3:89095126-89095137 (+)	4,682 bp
Tssr30058	Chr3:89095177-89095203 (+)	4,740 bp
Tssr30059	Chr3:89095228-89095272 (+)	4,800 bp
Tssr30060	Chr3:89095281-89095304 (+)	4,843 bp
Tssr30061	Chr3:89095627-89095635 (+)	5,181 bp
Tssr30062	Chr3:89095655-89095673 (+)	5,214 bp
Tssr30063	Chr3:89095712-89095717 (+)	5,265 bp