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Smim6 Gene Detail
Summary
  • Symbol
    Smim6
  • Name
    small integral membrane protein 6
  • Synonyms
    1110017F19Rik, ELN, endoregulin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915778
    NCBI Gene: 68528
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:115802843-115804743 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 80.91 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    179 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915778
 protein coding gene Chr11:115802843-115804746 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019406
 protein coding gene Chr11:119988565-119990467 (+)
A/J MGP_AJ_G0019375
 protein coding gene Chr11:114739910-114741848 (+)
AKR/J MGP_AKRJ_G0019345
 protein coding gene Chr11:118170241-118172143 (+)
BALB/cJ MGP_BALBcJ_G0019349
 protein coding gene Chr11:115155886-115157734 (+)
C3H/HeJ MGP_C3HHeJ_G0019155
 protein coding gene Chr11:118510919-118513342 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019799
 protein coding gene Chr11:123646441-123649877 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017422
 protein coding gene Chr11:111765231-111767119 (+)
CAST/EiJ MGP_CASTEiJ_G0018710
 protein coding gene Chr11:119856250-119859602 (+)
CBA/J MGP_CBAJ_G0019127
 protein coding gene Chr11:128542905-128544774 (+)
DBA/2J MGP_DBA2J_G0019238
 protein coding gene Chr11:114162997-114164877 (+)
FVB/NJ MGP_FVBNJ_G0019230
 protein coding gene Chr11:113671977-113673960 (+)
LP/J MGP_LPJ_G0019308
 protein coding gene Chr11:120368779-120370682 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019263
 protein coding gene Chr11:127654311-127657116 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019837
 protein coding gene Chr11:118820058-118822622 (+)
PWK/PhJ MGP_PWKPhJ_G0018474
 protein coding gene Chr11:115480484-115482324 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018267
 protein coding gene Chr11:118568068-118569950 (+)
WSB/EiJ MGP_WSBEiJ_G0018762
 protein coding gene Chr11:118784927-118786752 (+)



Homology
more
  • Human Ortholog
    ERLN, endoregulin
  • Vertebrate Orthologs
    1
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ERLN, endoregulin
  • Synonyms
    C17orf110, ELN, SMIM6
  • Links
    NCBI Gene ID: 100130933
    neXtProt AC: NX_P0DI80
    UniProt: P0DI80

  • Chr Location
    chr17:75646243-75647975 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    1
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    8
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 68528 NCBI Gene Model | MGI Sequence Detail 1901 C57BL/6J ±  kb
transcript NM_001162998 RefSeq | MGI Sequence Detail 975 C57BL/6  
polypeptide NP_001156470 RefSeq | MGI Sequence Detail 56 C57BL/6  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
Molecular
Reagents
less
  • All nucleic 8
    cDNA 8
References
more
  • Summaries
    All 18
    Developmental Gene Expression 1
    Gene Ontology 1
    Phenotypes 5
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory