Nufip2 MGI Mouse Gene Detail - MGI:1915814 - nuclear FMR1 interacting protein 2

Symbol

Nufip2
Name

nuclear FMR1 interacting protein 2
Synonyms

1110001M19Rik, 9530056D24Rik

Feature Type

protein coding gene
IDs

MGI:1915814
NCBI Gene: 68564
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr11:77576566-77608792 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 46.74 cM
Mapping Data

2 experiments

SNPs within 2kb

565 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915814	protein coding gene	Chr11:77576566-77632747 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018753	protein coding gene	Chr11:78623817-78689641 (+)
A/J	MGP_AJ_G0018719	protein coding gene	Chr11:75636268-75692487 (+)
AKR/J	MGP_AKRJ_G0018689	protein coding gene	Chr11:77933312-77992551 (+)
BALB/cJ	MGP_BALBcJ_G0018693	protein coding gene	Chr11:76031288-76088790 (+)
C3H/HeJ	MGP_C3HHeJ_G0018506	protein coding gene	Chr11:77963805-78027820 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019144	protein coding gene	Chr11:81093268-81157379 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016779	protein coding gene	Chr11:72609940-72640189 (+)
CAST/EiJ	MGP_CASTEiJ_G0018060	protein coding gene	Chr11:78381065-78437314 (+)
CBA/J	MGP_CBAJ_G0018476	protein coding gene	Chr11:84622784-84688652 (+)
DBA/2J	MGP_DBA2J_G0018585	protein coding gene	Chr11:75222065-75278887 (+)
FVB/NJ	MGP_FVBNJ_G0018575	protein coding gene	Chr11:74801447-74859083 (+)
LP/J	MGP_LPJ_G0018656	protein coding gene	Chr11:79176774-79238788 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018601	protein coding gene	Chr11:85071627-85135814 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019184	protein coding gene	Chr11:78155823-78222213 (+)
PWK/PhJ	MGP_PWKPhJ_G0017831	protein coding gene	Chr11:75981947-76046491 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017622	protein coding gene	Chr11:77760937-77786242 (+)
WSB/EiJ	MGP_WSBEiJ_G0018113	protein coding gene	Chr11:77975901-78038429 (+)

Human Ortholog

NUFIP2, nuclear FMR1 interacting protein 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NUFIP2, nuclear FMR1 interacting protein 2
Synonyms

182-FIP, 82-FIP, FIP-82, NUFP2, PIG1
Links

HGNC:17634

NCBI Gene ID: 57532

neXtProt AC: NX_Q7Z417

UniProt: Q7Z417
Chr Location

17q11.2; chr17:29255839-29294148 (-) GRCh38

MGI Vertebrate Homology

Nufip2 stringent orthology
1 human;1 mouse;2 rat;1 zebrafish
HCOP

vertebrate homology predictions: NUFIP2
Gene Tree

Nufip2

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Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
20 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

39
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

30
Targeted

4
Genomic Mutations

2 involving Nufip2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

53 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

18
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

81

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase nufip2

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All Sequences

52
RefSeq

8
UniProt

1
CCDS

CCDS25083.1

Ensembl

ENSMUSG00000037857 (Evidence)
NCBI Gene

68564

			Length	Strain/Species	Flank
genomic	68564	NCBI Gene Model \| MGI Sequence Detail	32227	C57BL/6J	± kb
transcript	NM_001024205	RefSeq \| MGI Sequence Detail	10399	C57BL/6
polypeptide	Q5F2E7	UniProt \| EBI \| MGI Sequence Detail	692	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000011502 FMR1-interacting protein NUFIP2

(term hierarchy)
InterPro Domains

IPR032747 FMR1-interacting protein 2
GlyGen

Q5F2E7 7 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (5 sites)

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All nucleic 81

cDNA 81

Microarray probesets 8

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MGI:1925921, MGI:2144097, MGI:2144180

Summaries

All 48

Gene Ontology 5

Phenotypes 20
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Nufip2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr103164	Chr11:77576579-77576608 (+)	28 bp
Tssr103165	Chr11:77576958-77576972 (+)	399 bp
Tssr103166	Chr11:77576987-77577005 (+)	430 bp
Tssr103167	Chr11:77577055-77577066 (+)	495 bp
Tssr103168	Chr11:77578077-77578100 (+)	1,523 bp
Tssr103169	Chr11:77584402-77584406 (+)	7,838 bp
Tssr103170	Chr11:77601274-77601277 (+)	24,710 bp
Tssr103171	Chr11:77601790-77601801 (+)	25,230 bp
Tssr103172	Chr11:77602380-77602393 (+)	25,821 bp
Tssr103173	Chr11:77604496-77604500 (+)	27,932 bp
Tssr103174	Chr11:77606020-77606024 (+)	29,456 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24