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Tmed10 Gene Detail
Summary
  • Symbol
    Tmed10
  • Name
    transmembrane p24 trafficking protein 10
  • Synonyms
    1110014C03Rik, p23, p24delta1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915831
    NCBI Gene: 68581
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:85387388-85421491 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 39.65 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    896 from dbSNP Build 142
  • Strain Annotations
    15
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915831
 protein coding gene Chr12:85387388-85421621 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019960
 protein coding gene Chr12:86114789-86151473 (-)
A/J MGP_AJ_G0019917
 protein coding gene Chr12:82844058-82878117 (-)
AKR/J MGP_AKRJ_G0019893
 protein coding gene Chr12:85092342-85131373 (-)
BALB/cJ MGP_BALBcJ_G0019897
 protein coding gene Chr12:83187569-83222188 (-)
C3H/HeJ MGP_C3HHeJ_G0019703
 protein coding gene Chr12:85562746-85598042 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020348
 protein coding gene Chr12:88602022-88639579 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017966
 protein coding gene Chr12:79736204-79770838 (-)
CAST/EiJ MGP_CASTEiJ_G0019252
 protein coding gene Chr12:80537989-80574944 (-)
CBA/J MGP_CBAJ_G0019674
 protein coding gene Chr12:91980786-92022355 (-)
DBA/2J no annotation
FVB/NJ MGP_FVBNJ_G0019775
 protein coding gene Chr12:81324092-81358219 (-)
LP/J MGP_LPJ_G0019861
 protein coding gene Chr12:85988083-86022534 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019814
 protein coding gene Chr12:94857196-94892346 (-)
NZO/HlLtJ no annotation
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0018811
 protein coding gene Chr12:79180556-79218125 (-)
WSB/EiJ MGP_WSBEiJ_G0019304
 protein coding gene Chr12:85429711-85471982 (-)



Homology
more
  • Human Ortholog
    TMED10, transmembrane p24 trafficking protein 10
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMED10, transmembrane p24 trafficking protein 10
  • Synonyms
    p23, p24d1, P24(DELTA), S31I125, S31III125, TMP21, Tmp-21-I
  • Links
    NCBI Gene ID: 10972
    neXtProt AC: NX_P49755
    UniProt: P49755

  • Chr Location
    14q24.3; chr14:75131469-75176612 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display embryonic lethality before implantation. Heterozygous mice display abnormalities of the Golgi apparatus.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    63
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    825
  • Tissues
    48
  • cDNA Data
    11
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 68581 NCBI Gene Model | MGI Sequence Detail 34104 C57BL/6J ±  kb
    transcript NM_026775 RefSeq | MGI Sequence Detail 3526 C57BL/6  
    polypeptide Q9D1D4 UniProt | EBI | MGI Sequence Detail 219 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000016402 transmembrane emp24 domain-containing protein 10
      (term hierarchy)
    • InterPro Domains
      IPR009038 GOLD domain
      IPR015720 Transmembrane emp24 domain-containing protein
    • GlyGen
      Q9D1D4 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 11
      Primer pair 1

      Microarray probesets 6
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 5
      Gene Ontology 11
      Phenotypes 21
    • Earliest
      J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory