Rtn4 MGI Mouse Gene Detail - MGI:1915835

Symbol

Rtn4
Name

reticulon 4
Synonyms

1110020G17Rik, C130026I10Rik, mKIAA0886, NgA, NOGO, Nogo-A, Nogo-B

Feature Type

protein coding gene
IDs

MGI:1915835
NCBI Gene: 68585
Alliance

gene page
Transcription Start Sites

23 TSS

Sequence Map

Chr11:29642947-29694331 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 16.79 cM
Mapping Data

2 experiments

SNPs within 2kb

1234 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915835	protein coding gene	Chr11:29642898-29694414 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018111	protein coding gene	Chr11:27715369-27775192 (+)
A/J	MGP_AJ_G0018083	protein coding gene	Chr11:26682234-26734703 (+)
AKR/J	MGP_AKRJ_G0018048	protein coding gene	Chr11:27558967-27610278 (+)
BALB/cJ	MGP_BALBcJ_G0018051	protein coding gene	Chr11:26886739-26942690 (+)
C3H/HeJ	MGP_C3HHeJ_G0017865	protein coding gene	Chr11:27470688-27524208 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018504	protein coding gene	Chr11:28658593-28714007 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016161	protein coding gene	Chr11:25313936-25365389 (+)
CAST/EiJ	MGP_CASTEiJ_G0017427	protein coding gene	Chr11:27533349-27587652 (+)
CBA/J	MGP_CBAJ_G0017839	protein coding gene	Chr11:30001002-30052077 (+)
DBA/2J	MGP_DBA2J_G0017949	protein coding gene	Chr11:26541455-26592783 (+)
FVB/NJ	MGP_FVBNJ_G0017941	protein coding gene	Chr11:26349476-26400596 (+)
LP/J	MGP_LPJ_G0018021	protein coding gene	Chr11:27964046-28018060 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017967	protein coding gene	Chr11:31124652-31181522 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018544	protein coding gene	Chr11:27663745-27721131 (+)
PWK/PhJ	MGP_PWKPhJ_G0017209	protein coding gene	Chr11:26631569-26684382 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017004	protein coding gene	Chr11:27360571-27417981 (+)
WSB/EiJ	MGP_WSBEiJ_G0017480	protein coding gene	Chr11:27361143-27415140 (+)

Human Ortholog

RTN4, reticulon 4

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RTN4, reticulon 4
Synonyms

ASY, Nbla00271, Nbla10545, NI220/250, NOGO, NSP, NSP-CL, RTN4-A, RTN4-B1, RTN4-B2, RTN4-C, RTN-X
Links

HGNC:14085

NCBI Gene ID: 57142

neXtProt AC: NX_Q9NQC3

UniProt: Q9NQC3
Chr Location

2p16.1; chr2:54972187-55137831 (-) GRCh38

MGI Vertebrate Homology

Rtn4 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: RTN4
Gene Tree

Rtn4

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Phenotype Summary

14 phenotypes from 9 alleles in 6 genetic backgrounds
1 phenotype from multigenic genotypes
81 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

125
Chemically induced (other)

1
Endonuclease-mediated

5
Gene trapped

109
Targeted

10
Genomic Mutations

1 involving Rtn4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

131 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mutant mice lacking the A and B isoforms are viable and one line shows enhanced regeneration and recovery after spinal cord injury. Different lines of mice lacking isoforms A, B, and C show varying phenotypes. Whereas some produce viable homozygotes, others are embryonic lethal.

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All GO Annotations

125
GO References

37

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1047
Tissues

182
cDNA Data

20
Literature Summary

29

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rtn4

ZFIN rtn4a, rtn4b

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All Sequences

94
RefSeq

10
UniProt

2
CCDS

CCDS24499.1, CCDS24500.1, CCDS24501.1, CCDS24502.1, CCDS24503.1

Ensembl

ENSMUSG00000020458 (Evidence)
NCBI Gene

68585

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020458	Ensembl Gene Model \| MGI Sequence Detail	51385	C57BL/6J	± kb
transcript	ENSMUST00000102843	Ensembl \| MGI Sequence Detail	4618	Not Applicable
polypeptide	ENSMUSP00000099907	Ensembl \| MGI Sequence Detail	1162	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000014348 reticulon-4

(term hierarchy)
PDB

2KO2
InterPro Domains

IPR003388 Reticulon

IPR046964 Reticulon 1-4
GlyGen

Q99P72 6 sites, 3 N-linked glycans (3 sites), 1 O-linked glycan (3 sites)

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All nucleic 26

cDNA 21

Primer pair 5

Microarray probesets 8

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MGI:2143973, MGI:2144005, MGI:2144056

Summaries

All 171

Developmental Gene Expression 29

Gene Ontology 37

Phenotypes 81
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:357471 Pagella P, et al., An unexpected role of neurite outgrowth inhibitor A as regulator of tooth enamel formation. Int J Oral Sci. 2024;16(1):60

TSS for Rtn4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr100723	Chr11:29642312-29642328 (+)	-627 bp
Tssr100724	Chr11:29642937-29642997 (+)	20 bp
Tssr100725	Chr11:29643004-29643015 (+)	63 bp
Tssr100726	Chr11:29643033-29643047 (+)	93 bp
Tssr100727	Chr11:29643159-29643168 (+)	217 bp
Tssr100728	Chr11:29654277-29654284 (+)	11,334 bp
Tssr100729	Chr11:29656788-29656818 (+)	13,856 bp
Tssr100730	Chr11:29656996-29657022 (+)	14,062 bp
Tssr100731	Chr11:29657283-29657295 (+)	14,342 bp
Tssr100732	Chr11:29657397-29657416 (+)	14,460 bp
Tssr100733	Chr11:29657733-29657758 (+)	14,799 bp
Tssr100734	Chr11:29660813-29660829 (+)	17,874 bp
Tssr100735	Chr11:29662813-29662819 (+)	19,869 bp
Tssr100736	Chr11:29665691-29665703 (+)	22,750 bp
Tssr100737	Chr11:29668697-29668753 (+)	25,778 bp
Tssr100738	Chr11:29668781-29668782 (+)	25,835 bp
Tssr100739	Chr11:29668785-29668791 (+)	25,841 bp
Tssr100740	Chr11:29668795-29668839 (+)	25,870 bp
Tssr100741	Chr11:29669130-29669157 (+)	26,197 bp
Tssr100742	Chr11:29681501-29681507 (+)	38,557 bp
Tssr100743	Chr11:29691459-29691482 (+)	48,524 bp
Tssr100744	Chr11:29692083-29692143 (+)	49,166 bp
Tssr100745	Chr11:29692348-29692406 (+)	49,430 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24