Ube2c MGI Mouse Gene Detail - MGI:1915862 - ubiquitin-conjugating enzyme E2C

Symbol

Ube2c
Name

ubiquitin-conjugating enzyme E2C
Synonyms

1110015A16Rik, D2Ertd695e

Feature Type

protein coding gene
IDs

MGI:1915862
NCBI Gene: 68612
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr2:164611849-164614822 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 85.27 cM
Mapping Data

3 experiments

SNPs within 2kb

196 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915862	protein coding gene	Chr2:164611818-164620742 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026871	protein coding gene	Chr2:170267397-170276638 (+)
A/J	MGP_AJ_G0026838	protein coding gene	Chr2:163308551-163317407 (+)
AKR/J	MGP_AKRJ_G0026809	protein coding gene	Chr2:168162597-168171620 (+)
BALB/cJ	MGP_BALBcJ_G0026847	protein coding gene	Chr2:163667366-163676222 (+)
C3H/HeJ	MGP_C3HHeJ_G0026589	protein coding gene	Chr2:168526263-168535187 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027294	protein coding gene	Chr2:175198355-175207143 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024665	protein coding gene	Chr2:156714424-156723336 (+)
CAST/EiJ	MGP_CASTEiJ_G0026047	protein coding gene	Chr2:168942430-168950976 (+)
CBA/J	MGP_CBAJ_G0026566	protein coding gene	Chr2:181554662-181563473 (+)
DBA/2J	MGP_DBA2J_G0026704	protein coding gene	Chr2:162474020-162482876 (+)
FVB/NJ	MGP_FVBNJ_G0026670	protein coding gene	Chr2:160894736-160903592 (+)
LP/J	MGP_LPJ_G0026806	protein coding gene	Chr2:170326036-170334519 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026689	protein coding gene	Chr2:185125015-185133498 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027351	protein coding gene	Chr2:168067440-168075923 (+)
PWK/PhJ	MGP_PWKPhJ_G0025784	protein coding gene	Chr2:162074283-162083140 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025585	protein coding gene	Chr2:166966309-166974884 (+)
WSB/EiJ	MGP_WSBEiJ_G0026120	protein coding gene	Chr2:168948729-168958511 (+)

Human Ortholog

UBE2C, ubiquitin conjugating enzyme E2 C

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

UBE2C, ubiquitin conjugating enzyme E2 C
Synonyms

dJ447F3.2, UBCH10
Links

HGNC:15937

NCBI Gene ID: 11065

neXtProt AC: NX_O00762

UniProt: O00762
Chr Location

20q13.12; chr20:45812576-45816957 (+) GRCh38

MGI Vertebrate Homology

Ube2c stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: UBE2C
Gene Tree

Ube2c

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Phenotype Summary

6 phenotypes from 2 alleles in 2 genetic backgrounds
3 phenotypes from multigenic genotypes
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

17
Endonuclease-mediated

4
Gene trapped

11
Targeted

2
Incidental Mutations

APF
Find Mice (IMSR)

25 strains or lines available

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All GO Annotations

39
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

725
Tissues

18
cDNA Data

74
Literature Summary

10

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ube2c

ZFIN ube2c

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All Sequences

40
RefSeq

2
UniProt

4
CCDS

CCDS17055.1

Ensembl

ENSMUSG00000001403 (Evidence)
NCBI Gene

68612

			Length	Strain/Species	Flank
genomic	68612	NCBI Gene Model \| MGI Sequence Detail	2974	C57BL/6J	± kb
transcript	NM_026785	RefSeq \| MGI Sequence Detail	931	ZRU/MplStud
polypeptide	Q9D1C1	UniProt \| EBI \| MGI Sequence Detail	179	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000016967 ubiquitin-conjugating enzyme E2 C

(term hierarchy)
EC

2.3.2.23, 2.3.2.24
InterPro Domains

IPR050113 Ubiquitin-conjugating enzyme

IPR023313 Ubiquitin-conjugating enzyme, active site

IPR000608 Ubiquitin-conjugating enzyme E2

IPR016135 Ubiquitin-conjugating enzyme/RWD-like
GlyGen

Q9D1C1 1 site, 1 O-linked glycan (1 site)

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All nucleic 75

cDNA 74

Primer pair 1

Microarray probesets 2

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MGI:1277160

Summaries

All 51

Developmental Gene Expression 10

Gene Ontology 6

Phenotypes 14
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:347974 Zhou B, et al., Identification of signaling pathways that specify a subset of migrating enteric neural crest cells at the wavefront in mouse embryos. Dev Cell. 2024 Apr 15;

TSS for Ube2c:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr21637	Chr2:164611812-164611823 (+)	-31 bp
Tssr21638	Chr2:164611841-164611874 (+)	9 bp
Tssr21639	Chr2:164611883-164611894 (+)	40 bp
Tssr21640	Chr2:164613221-164613244 (+)	1,384 bp
Tssr21641	Chr2:164613606-164613617 (+)	1,763 bp
Tssr21642	Chr2:164613782-164613799 (+)	1,942 bp
Tssr21643	Chr2:164613814-164613823 (+)	1,970 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24