Cryl1 MGI Mouse Gene Detail - MGI:1915881

Symbol

Cryl1
Name

crystallin, lambda 1
Synonyms

1110025H08Rik, A230106J09Rik

Feature Type

protein coding gene
IDs

MGI:1915881
NCBI Gene: 68631
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr14:57512491-57635940 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 30.10 cM, cytoband C2
Mapping Data

4 experiments

SNPs within 2kb

3164 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915881	protein coding gene	Chr14:57512450-57635986 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0021405	protein coding gene	Chr14:51442798-51576249 (-)
A/J	MGP_AJ_G0021366	protein coding gene	Chr14:50434686-50559159 (-)
AKR/J	MGP_AKRJ_G0021341	protein coding gene	Chr14:52204249-52327045 (-)
BALB/cJ	MGP_BALBcJ_G0021369	protein coding gene	Chr14:50379924-50506679 (-)
C3H/HeJ	MGP_C3HHeJ_G0021148	protein coding gene	Chr14:51853499-51984476 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0021808	protein coding gene	Chr14:54001821-54135088 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019348	protein coding gene	Chr14:48513745-48644775 (-)
CAST/EiJ	MGP_CASTEiJ_G0020666	protein coding gene	Chr14:48193254-48319988 (-)
CBA/J	MGP_CBAJ_G0021115	protein coding gene	Chr14:55574946-55718637 (-)
DBA/2J	MGP_DBA2J_G0021236	protein coding gene	Chr14:50114882-50238301 (-)
FVB/NJ	MGP_FVBNJ_G0021217	protein coding gene	Chr14:49499551-49623420 (-)
LP/J	MGP_LPJ_G0021311	protein coding gene	Chr14:52495575-52625630 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021245	protein coding gene	Chr14:54959890-55090502 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021832	protein coding gene	Chr14:51351386-51479560 (-)
PWK/PhJ	MGP_PWKPhJ_G0020409	protein coding gene	Chr14:46649271-46774934 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020242	protein coding gene	Chr14:47417546-47546982 (-)
WSB/EiJ	MGP_WSBEiJ_G0020718	protein coding gene	Chr14:51675544-51803823 (-)

Human Ortholog

CRYL1, crystallin lambda 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CRYL1, crystallin lambda 1
Synonyms

GDH, gul3DH, HEL30, lambda-CRY
Links

HGNC:18246

NCBI Gene ID: 51084

neXtProt AC: NX_Q9Y2S2

UniProt: Q9Y2S2
Chr Location

13q12.11; chr13:20403666-20525873 (-) GRCh38

MGI Vertebrate Homology

Cryl1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CRYL1
Protein SuperFamily

HCDH
Gene Tree

Cryl1

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References

1 with disease annotations

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Phenotype Summary

11 phenotype references

All Mutations and Alleles

10
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

3
Targeted

2
Genomic Mutations

2 involving Cryl1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

23 strains or lines available

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All GO Annotations

11
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

945
Tissues

194
cDNA Data

62
Literature Summary

5

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cryl1

ZFIN cryl1

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All Sequences

49
RefSeq

2
UniProt

3
CCDS

CCDS27155.1

Ensembl

ENSMUSG00000021947 (Evidence)
NCBI Gene

68631

			Length	Strain/Species	Flank
genomic	68631	NCBI Gene Model \| MGI Sequence Detail	123450	C57BL/6J	± kb
transcript	NM_030004	RefSeq \| MGI Sequence Detail	1410	ZRU/MplStud
polypeptide	Q99KP3	UniProt \| EBI \| MGI Sequence Detail	319	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000005920 lambda-crystallin

(term hierarchy)
EC

1.1.1.45
InterPro Domains

IPR022694 3-hydroxyacyl-CoA dehydrogenase

IPR006180 3-hydroxyacyl-CoA dehydrogenase, conserved site

IPR006108 3-hydroxyacyl-CoA dehydrogenase, C-terminal

IPR006176 3-hydroxyacyl-CoA dehydrogenase, NAD binding

IPR013328 6-phosphogluconate dehydrogenase, domain 2

IPR008927 6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily

IPR036291 NAD(P)-binding domain superfamily

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All nucleic 64

cDNA 62

Primer pair 2

Microarray probesets 6

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MGI:1925166, MGI:2145872

Summaries

All 46

Developmental Gene Expression 5

Diseases 1

Gene Ontology 7

Phenotypes 11
Earliest

J:323240 Tulsiani DR, et al., Studies on dehydrogenases of the glucuronate-xylulose cycle in the livers of diabetic mice and rats. Diabetes. 1979 Sep;28(9):793-8
Latest

J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

TSS for Cryl1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr128965	Chr14:57635970-57635987 (-)	-39 bp
Tssr128964	Chr14:57635943-57635966 (-)	-15 bp
Tssr128963	Chr14:57616824-57616876 (-)	19,090 bp
Tssr128962	Chr14:57613545-57613550 (-)	22,392 bp
Tssr128961	Chr14:57565837-57565838 (-)	70,102 bp
Tssr128960	Chr14:57543677-57543682 (-)	92,260 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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