Myct1 MGI Mouse Gene Detail - MGI:1915882

Symbol

Myct1
Name

myc target 1
Synonyms

1110020B04Rik, Mtmc1, MT-MC1

Feature Type

protein coding gene
IDs

MGI:1915882
NCBI Gene: 68632
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr10:5543728-5556789 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 1.99 cM, cytoband A1
Mapping Data

3 experiments

SNPs within 2kb

527 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915882	protein coding gene	Chr10:5543728-5556904 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016984	protein coding gene	Chr10:2671044-2684915 (+)
A/J	MGP_AJ_G0016962	protein coding gene	Chr10:2516051-2530955 (+)
AKR/J	MGP_AKRJ_G0016927	protein coding gene	Chr10:2522079-2538785 (+)
BALB/cJ	MGP_BALBcJ_G0016920	protein coding gene	Chr10:2493245-2506165 (+)
C3H/HeJ	MGP_C3HHeJ_G0016745	protein coding gene	Chr10:2648731-2661083 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017383	protein coding gene	Chr10:2721028-2734087 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015089	protein coding gene	Chr10:2287535-2299937 (+)
CAST/EiJ	MGP_CASTEiJ_G0016327	protein coding gene	Chr10:2686401-2698736 (+)
CBA/J	MGP_CBAJ_G0016717	protein coding gene	Chr10:2831354-2843767 (+)
DBA/2J	MGP_DBA2J_G0016825	protein coding gene	Chr10:2497809-2510765 (+)
FVB/NJ	MGP_FVBNJ_G0016820	protein coding gene	Chr10:2461295-2473553 (+)
LP/J	MGP_LPJ_G0016900	protein coding gene	Chr10:2600692-2614539 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016851	protein coding gene	Chr10:2697007-2709345 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017420	protein coding gene	Chr10:2573366-2586983 (+)
PWK/PhJ	MGP_PWKPhJ_G0016113	protein coding gene	Chr10:2514841-2527541 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015895	protein coding gene	Chr10:2766918-2779606 (+)
WSB/EiJ	MGP_WSBEiJ_G0016389	protein coding gene	Chr10:2621851-2634188 (+)

Human Ortholog

MYCT1, MYC target 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MYCT1, MYC target 1
Synonyms

MTLC
Links

HGNC:23172

NCBI Gene ID: 80177

neXtProt AC: NX_Q8N699

UniProt: Q8N699
Chr Location

6q25.2; chr6:152697897-152747181 (+) GRCh38

MGI Vertebrate Homology

Myct1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: MYCT1
Gene Tree

Myct1

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Phenotype Summary

14 phenotypes from 2 alleles in 2 genetic backgrounds
2 phenotypes from multigenic genotypes
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

3
Gene trapped

1
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

14 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit restricted tumor progression in various tumor models, showing reduced angiogenesis to tumors, enhanced high endothelial venule formation, and an antitumor immune microenvironment.

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All GO Annotations

7
GO References

5

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

751
Tissues

44
cDNA Data

30
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase myct1

ZFIN myct1a

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All Sequences

39
RefSeq

2
UniProt

1
CCDS

CCDS56681.1

Ensembl

ENSMUSG00000046916 (Evidence)
NCBI Gene

68632

			Length	Strain/Species	Flank
genomic	68632	NCBI Gene Model \| MGI Sequence Detail	13062	C57BL/6J	± kb
transcript	NM_026793	RefSeq \| MGI Sequence Detail	2792	C57BL/6
polypeptide	Q8R411	UniProt \| EBI \| MGI Sequence Detail	188	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000010814 Myc target protein 1

(term hierarchy)
InterPro Domains

IPR029180 Myc target protein 1

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All nucleic 30

cDNA 30

Microarray probesets 5

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MGI:2143542, MGI:2143656

Summaries

All 40

Developmental Gene Expression 2

Gene Ontology 5

Phenotypes 9
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Myct1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr92284	Chr10:5543718-5543739 (+)	1 bp
Tssr92285	Chr10:5543764-5543809 (+)	59 bp
Tssr92286	Chr10:5543810-5543821 (+)	88 bp
Tssr92287	Chr10:5543823-5543855 (+)	111 bp
Tssr92288	Chr10:5544772-5544775 (+)	1,046 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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