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Fndc1 Gene Detail
Summary
  • Symbol
    Fndc1
  • Name
    fibronectin type III domain containing 1
  • Synonyms
    1110027O12Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915905
    NCBI Gene: 68655
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:7957401-8046134 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 4.77 cM, cytoband A1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2803 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915905
 protein coding gene Chr17:7957401-8046158 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023120
 protein coding gene Chr17:4982908-5072244 (-)
A/J MGP_AJ_G0023094
 protein coding gene Chr17:5242556-5331233 (-)
AKR/J MGP_AKRJ_G0023056
 protein coding gene Chr17:4404573-4504754 (+)
BALB/cJ MGP_BALBcJ_G0023096
 protein coding gene Chr17:5037252-5125280 (-)
C3H/HeJ MGP_C3HHeJ_G0022855
 protein coding gene Chr17:5143018-5232741 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023535
 protein coding gene Chr17:5249382-5350478 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021038
 protein coding gene Chr17:3588595-3677055 (+)
CAST/EiJ MGP_CASTEiJ_G0022366
 protein coding gene Chr17:4944697-5032697 (-)
CBA/J MGP_CBAJ_G0022825
 protein coding gene Chr17:5598372-5692723 (-)
DBA/2J MGP_DBA2J_G0022964
 protein coding gene Chr17:4911963-5000273 (-)
FVB/NJ MGP_FVBNJ_G0022931
 protein coding gene Chr17:4826268-4914729 (-)
LP/J MGP_LPJ_G0023025
 protein coding gene Chr17:4407874-4505785 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022950
 protein coding gene Chr17:5380994-5473355 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023560
 protein coding gene Chr17:5113090-5204809 (-)
PWK/PhJ MGP_PWKPhJ_G0022115
 protein coding gene Chr17:4479856-4571027 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021942
 protein coding gene Chr17:4043139-4131857 (+)
WSB/EiJ MGP_WSBEiJ_G0022422
 protein coding gene Chr17:5194248-5284523 (-)



Homology
more
  • Human Ortholog
    FNDC1, fibronectin type III domain containing 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FNDC1, fibronectin type III domain containing 1
  • Synonyms
    AGS8, bA243O10.1, dJ322A24.1, FNDC2, MEL4B3
  • Links
    NCBI Gene ID: 84624
    neXtProt AC: NX_Q4ZHG4
    UniProt: Q4ZHG4

  • Chr Location
    6q25.3; chr6:159169400-159272108 (+)  GRCh38
Human Diseases
less
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    358 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    1
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    814
  • Tissues
    16
  • cDNA Data
    32
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000071984 Ensembl Gene Model | MGI Sequence Detail 88734 C57BL/6J ±  kb
transcript ENSMUST00000239425 Ensembl | MGI Sequence Detail 6333 Not Applicable  
polypeptide ENSMUSP00000159298 Ensembl | MGI Sequence Detail 1833 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    7 Sequences
  • InterPro Domains
    IPR003961 Fibronectin type III
    IPR036116 Fibronectin type III superfamily
    IPR013783 Immunoglobulin-like fold
    IPR049109 Target of Nesh-SH3/FNDC1, C-terminal domain
Molecular
Reagents
less
  • All nucleic 37
    cDNA 33
    Primer pair 2
    Other 2

    Microarray probesets 3
References
more
  • Summaries
    All 382
    Developmental Gene Expression 4
    Diseases 6
    Gene Ontology 1
    Phenotypes 358
  • Earliest
    J:30229 Davisson MT, et al., Segmental trisomy as a mouse model for Down syndrome. Prog Clin Biol Res. 1993;384:117-33
  • Latest
    J:354984 Emili M, et al., Reversal of neurodevelopmental impairment and cognitive enhancement by pharmacological intervention with the polyphenol polydatin in a Down syndrome model. Neuropharmacology. 2024 Sep 27;261:110170
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory