Slc25a25 MGI Mouse Gene Detail - MGI:1915913 - solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 25

Symbol

Slc25a25
Name

solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 25
Synonyms

1110030N17Rik, mKIAA1896

Feature Type

protein coding gene
IDs

MGI:1915913
NCBI Gene: 227731
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr2:32304499-32341457 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 22.09 cM
Mapping Data

1 experiment

SNPs within 2kb

693 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915913	protein coding gene	Chr2:32304499-32341482 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0025607	protein coding gene	Chr2:30874165-30911139 (-)
A/J	MGP_AJ_G0025584	protein coding gene	Chr2:29561579-29598217 (-)
AKR/J	MGP_AKRJ_G0025554	protein coding gene	Chr2:30621433-30658394 (-)
BALB/cJ	MGP_BALBcJ_G0025581	protein coding gene	Chr2:29688872-29726028 (-)
C3H/HeJ	MGP_C3HHeJ_G0025341	protein coding gene	Chr2:30511029-30548382 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0026025	protein coding gene	Chr2:31825143-31862843 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023434	protein coding gene	Chr2:28284323-28321897 (-)
CAST/EiJ	MGP_CASTEiJ_G0024803	protein coding gene	Chr2:30449542-30486491 (-)
CBA/J	MGP_CBAJ_G0025319	protein coding gene	Chr2:33012535-33053242 (-)
DBA/2J	MGP_DBA2J_G0025452	protein coding gene	Chr2:29329008-29366621 (-)
FVB/NJ	MGP_FVBNJ_G0025414	protein coding gene	Chr2:29205820-29242627 (-)
LP/J	MGP_LPJ_G0025538	protein coding gene	Chr2:30750477-30787520 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025445	protein coding gene	Chr2:32668660-32706531 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026083	protein coding gene	Chr2:30502738-30539603 (-)
PWK/PhJ	MGP_PWKPhJ_G0024551	protein coding gene	Chr2:29233336-29270801 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0024351	protein coding gene	Chr2:30657434-30696105 (-)
WSB/EiJ	MGP_WSBEiJ_G0024872	protein coding gene	Chr2:30672602-30709566 (-)

Human Ortholog

SLC25A25, solute carrier family 25 member 25

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC25A25, solute carrier family 25 member 25
Synonyms

MCSC, PCSCL, SCAMC-2, SCAMC2
Links

HGNC:20663

NCBI Gene ID: 114789

neXtProt AC: NX_Q6KCM7

UniProt: Q6KCM7
Chr Location

9q34.11; chr9:128068201-128109245 (+) GRCh38

MGI Vertebrate Homology

Slc25a25 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: SLC25A25
Gene Tree

Slc25a25

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Phenotype Summary

13 phenotypes from 1 allele in 1 genetic background
4 phenotypes from multigenic genotypes
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Endonuclease-mediated

1
Gene trapped

8
Targeted

5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

41 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit reduced physical endurance and metabolic efficiency.

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All GO Annotations

21
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

800
Tissues

43
cDNA Data

15
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase slc25a25

ZFIN slc25a25a, slc25a25b

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All Sequences

81
RefSeq

16
UniProt

4
CCDS

CCDS15915.1, CCDS50567.1, CCDS50568.1, CCDS71028.1, CCDS89474.1

Ensembl

ENSMUSG00000026819 (Evidence)
NCBI Gene

227731

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026819	Ensembl Gene Model \| MGI Sequence Detail	36959	C57BL/6J	± kb
transcript	ENSMUST00000028160	Ensembl \| MGI Sequence Detail	3294	Not Applicable
polypeptide	ENSMUSP00000028160	Ensembl \| MGI Sequence Detail	514	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000015021 mitochondrial adenyl nucleotide antiporter SLC25A25

(term hierarchy)
InterPro Domains

IPR002048 EF-hand domain

IPR011992 EF-hand domain pair

IPR023395 Mitochondrial carrier domain superfamily

IPR002067 Mitochondrial carrier protein

IPR018108 Mitochondrial substrate/solute carrier

IPR002167 Solute carrier family 25 member 16-like
GlyGen

A2ASZ8 1 site, 1 N-linked glycan (1 site)

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All nucleic 16

cDNA 15

Primer pair 1

Microarray probesets 6

Summaries

All 43

Developmental Gene Expression 2

Gene Ontology 11

Phenotypes 12
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Slc25a25:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr23524	Chr2:32343196-32343202 (-)	-1,742 bp
Tssr23523	Chr2:32341408-32341482 (-)	12 bp
Tssr23522	Chr2:32341380-32341391 (-)	71 bp
Tssr23521	Chr2:32321127-32321190 (-)	20,298 bp
Tssr23520	Chr2:32314069-32314091 (-)	27,377 bp
Tssr23519	Chr2:32314056-32314067 (-)	27,395 bp
Tssr23518	Chr2:32314019-32314041 (-)	27,427 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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