Svop MGI Mouse Gene Detail - MGI:1915916

Symbol

Svop
Name

SV2 related protein
Synonyms

1110030H18Rik, msvop

Feature Type

protein coding gene
IDs

MGI:1915916
NCBI Gene: 68666
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr5:114164974-114229441 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 55.94 cM, cytoband F
Mapping Data

3 experiments

SNPs within 2kb

2122 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915916	protein coding gene	Chr5:114164971-114229631 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0029929	protein coding gene	Chr5:116738442-116802743 (-)
A/J	MGP_AJ_G0029894	protein coding gene	Chr5:112155524-112221296 (-)
AKR/J	MGP_AKRJ_G0029832	protein coding gene	Chr5:115718595-115784324 (-)
BALB/cJ	MGP_BALBcJ_G0029905	protein coding gene	Chr5:113522935-113588713 (-)
C3H/HeJ	MGP_C3HHeJ_G0029625	protein coding gene	Chr5:116207800-116275422 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0030359	protein coding gene	Chr5:121251692-121322968 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027587	protein coding gene	Chr5:106981185-107046406 (-)
CAST/EiJ	MGP_CASTEiJ_G0029033	protein coding gene	Chr5:115133510-115205278 (-)
CBA/J	MGP_CBAJ_G0029592	protein coding gene	Chr5:125841303-125917395 (-)
DBA/2J	MGP_DBA2J_G0029742	protein coding gene	Chr5:112215689-112281201 (-)
FVB/NJ	MGP_FVBNJ_G0029699	protein coding gene	Chr5:111004908-111071760 (-)
LP/J	MGP_LPJ_G0029831	protein coding gene	Chr5:117302707-117370675 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029730	protein coding gene	Chr5:130325066-130397103 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030400	protein coding gene	Chr5:115173605-115241912 (-)
PWK/PhJ	MGP_PWKPhJ_G0028747	protein coding gene	Chr5:110844448-110909868 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0028585	protein coding gene	Chr5:112715524-112783674 (-)
WSB/EiJ	MGP_WSBEiJ_G0029109	protein coding gene	Chr5:115740456-115808879 (-)

Human Ortholog

SVOP, SV2 related protein

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SVOP, SV2 related protein
Synonyms

SLC22B4
Links

HGNC:25417

NCBI Gene ID: 55530

neXtProt AC: NX_Q8N4V2

UniProt: Q8N4V2
Chr Location

12q24.11; chr12:108907741-109021068 (-) GRCh38

MGI Vertebrate Homology

Svop stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: SVOP
Gene Tree

Svop

less

Phenotype Summary

7 phenotypes from 3 alleles in 3 genetic backgrounds
2 phenotypes from multigenic genotypes
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

1
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Svop
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

32 strains or lines available

Mice homozygous for a knock-out allele are viable with no phenotypic abnormalities.

less

All GO Annotations

6
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1026
Tissues

183
cDNA Data

28
Literature Summary

6

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase svop

less

All Sequences

43
RefSeq

4
UniProt

2
CCDS

CCDS39220.1

Ensembl

ENSMUSG00000042078 (Evidence)
NCBI Gene

68666

			Length	Strain/Species	Flank
genomic	68666	NCBI Gene Model \| MGI Sequence Detail	64468	C57BL/6J	± kb
transcript	NM_001359214	RefSeq \| MGI Sequence Detail	3353	C57BL/6
polypeptide	Q8BFT9	UniProt \| EBI \| MGI Sequence Detail	548	Not Applicable

less

UniProt

2 Sequences
Protein Ontology

PR:000015855 synaptic vesicle 2-related protein

(term hierarchy)
InterPro Domains

IPR005828 Major facilitator, sugar transporter-like

IPR011701 Major facilitator superfamily

IPR020846 Major facilitator superfamily domain

IPR036259 MFS transporter superfamily

IPR004749 Organic cation transport protein/SVOP

IPR047969 Synaptic vesicle 2-related protein-like, major facilitator superfamily domain

less

All nucleic 30

cDNA 28

Primer pair 2

Microarray probesets 3

less

MGI:2140865

Summaries

All 46

Developmental Gene Expression 6

Gene Ontology 4

Phenotypes 12
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Svop:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr52693	Chr5:114229419-114229465 (-)	-1 bp
Tssr52692	Chr5:114229392-114229407 (-)	41 bp
Tssr52691	Chr5:114229359-114229385 (-)	69 bp
Tssr52690	Chr5:114229326-114229348 (-)	104 bp
Tssr52689	Chr5:114229251-114229284 (-)	173 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24