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Taok2 Gene Detail
Summary
  • Symbol
    Taok2
  • Name
    TAO kinase 2
  • Synonyms
    1110033K02Rik, MAP3K17, mKIAA0881, PSK1, TAO1, TAO2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915919
    NCBI Gene: 381921
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:126464850-126483875 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 69.25 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    294 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915919
 protein coding gene Chr7:126464848-126485468 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033006
 protein coding gene Chr7:131172079-131190997 (-)
A/J MGP_AJ_G0032989
 protein coding gene Chr7:127691510-127710534 (-)
AKR/J MGP_AKRJ_G0032921
 protein coding gene Chr7:130926806-130945830 (-)
BALB/cJ MGP_BALBcJ_G0032994
 protein coding gene Chr7:127355013-127374053 (-)
C3H/HeJ MGP_C3HHeJ_G0032704
 protein coding gene Chr7:130864966-130883992 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033500
 protein coding gene Chr7:136272528-136291530 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030472
 protein coding gene Chr7:128885277-128904335 (-)
CAST/EiJ MGP_CASTEiJ_G0032033
 protein coding gene Chr7:122650922-122669724 (-)
CBA/J MGP_CBAJ_G0032677
 protein coding gene Chr7:140861297-140880323 (-)
DBA/2J MGP_DBA2J_G0032829
 protein coding gene Chr7:125667063-125686084 (-)
FVB/NJ MGP_FVBNJ_G0032782
 protein coding gene Chr7:125518265-125537230 (-)
LP/J MGP_LPJ_G0032923
 protein coding gene Chr7:132638241-132657258 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032814
 protein coding gene Chr7:142030128-142049149 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033519
 protein coding gene Chr7:129937506-129956531 (-)
PWK/PhJ MGP_PWKPhJ_G0031740
 protein coding gene Chr7:118661549-118680692 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031586
 protein coding gene Chr7:116782312-116801058 (-)
WSB/EiJ MGP_WSBEiJ_G0032145
 protein coding gene Chr7:130915804-130934816 (-)



Homology
more
  • Human Ortholog
    TAOK2, TAO kinase 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TAOK2, TAO kinase 2
  • Synonyms
    MAP3K17, PSK, PSK1, PSK1-BETA, TAO1, TAO2, Tao2beta
  • Links
    NCBI Gene ID: 9344
    neXtProt AC: NX_Q9UL54
    UniProt: Q9UL54

  • Chr Location
    16p11.2; chr16:29973868-29992261 (+)  GRCh38
Human Diseases
less
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 4 alleles in 4 genetic backgrounds
    50 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a transgenic gene disruption exhibit decreased body size. Mice homozygous for a targeted allele exhibit resistance to the ataxic effect of alcohol, reduced blood ethanol content, increased alcohol consumption, impaired CPP for alcohol, and impaired habituation in an open field.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    78
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    750
  • Tissues
    22
  • cDNA Data
    56
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000059981 Ensembl Gene Model | MGI Sequence Detail 19026 C57BL/6J ±  kb
    transcript ENSMUST00000117394 Ensembl | MGI Sequence Detail 4985 Not Applicable  
    polypeptide ENSMUSP00000112963 Ensembl | MGI Sequence Detail 1240 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 59
      Genomic 2
      cDNA 57

      Microarray probesets 4
    References
    more
    • Summaries
      All 85
      Developmental Gene Expression 3
      Diseases 3
      Gene Ontology 12
      Phenotypes 50
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:349484 Henis M, et al., The autism susceptibility kinase, TAOK2, phosphorylates eEF2 and modulates translation. Sci Adv. 2024 Apr 12;10(15):eadf7001
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory