Ifitm1 MGI Mouse Gene Detail - MGI:1915963 - interferon induced transmembrane protein 1

Symbol

Ifitm1
Name

interferon induced transmembrane protein 1
Synonyms

1110036C17Rik, fragilis2, Mil2

Feature Type

protein coding gene
IDs

MGI:1915963
NCBI Gene: 68713
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr7:140547342-140549740 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 86.20 cM, cytoband F5
Mapping Data

3 experiments

SNPs within 2kb

189 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915963	protein coding gene	Chr7:140547134-140549740 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033204	protein coding gene	Chr7:146106356-146108960 (+)
A/J	MGP_AJ_G0033186	protein coding gene	Chr7:141950991-141953595 (+)
AKR/J	MGP_AKRJ_G0033118	protein coding gene	Chr7:145846247-145848851 (+)
BALB/cJ	MGP_BALBcJ_G0033187	protein coding gene	Chr7:141679071-141681675 (+)
C3H/HeJ	MGP_C3HHeJ_G0032901	protein coding gene	Chr7:145602943-145605547 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0033698	protein coding gene	Chr7:151453915-151456519 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030671	protein coding gene	Chr7:143162100-143165039 (+)
CAST/EiJ	MGP_CASTEiJ_G0032231	protein coding gene	Chr7:137903159-137906156 (+)
CBA/J	MGP_CBAJ_G0032873	protein coding gene	Chr7:156579523-156582127 (+)
DBA/2J	MGP_DBA2J_G0033026	protein coding gene	Chr7:139889417-139892021 (+)
FVB/NJ	MGP_FVBNJ_G0032978	protein coding gene	Chr7:139803071-139805675 (+)
LP/J	MGP_LPJ_G0033120	protein coding gene	Chr7:147614803-147617407 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033011	protein coding gene	Chr7:157242476-157245080 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033718	protein coding gene	Chr7:144826717-144829321 (+)
PWK/PhJ	MGP_PWKPhJ_G0031935	protein coding gene	Chr7:133165088-133168020 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031782	protein coding gene	Chr7:131647822-131650532 (+)
WSB/EiJ	MGP_WSBEiJ_G0032342	protein coding gene	Chr7:145748673-145751276 (+)

Human Ortholog

IFITM1, interferon induced transmembrane protein 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

IFITM1, interferon induced transmembrane protein 1
Synonyms

9-27, CD225, DSPA2a, IFI17, LEU13
Links

HGNC:5412

NCBI Gene ID: 8519

neXtProt AC: NX_P13164

UniProt: P13164
Chr Location

11p15.5; chr11:310041-315272 (+) GRCh38

MGI Vertebrate Homology

Ifitm1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: IFITM1
Gene Tree

Ifitm1

Diseases

2 with human IFITM1 associations

				Human Disease	Mouse Models
				adenosquamous gallbladder carcinoma IDs adenosquamous gallbladder carcinoma DOID:5627 NCI:C7356 UMLS_CUI:C1333741
				gallbladder adenocarcinoma IDs gallbladder adenocarcinoma DOID:3500 NCI:C9166 UMLS_CUI:C0279651

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

17 phenotypes from 3 alleles in 4 genetic backgrounds
25 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

60
Endonuclease-mediated

1
Gene trapped

52
Radiation induced

1
Targeted

6
Genomic Mutations

2 involving Ifitm1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

42 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutant mice exhibited enhanced motor coordination during inverted screen testing when compared with that of their wild-type littermates.

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All GO Annotations

36
GO References

9

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

979
Tissues

125
cDNA Data

51
Literature Summary

13

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ifitm1

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All Sequences

46
RefSeq

8
UniProt

1
CCDS

CCDS21995.1

Ensembl

ENSMUSG00000025491 (Evidence)
NCBI Gene

68713

			Length	Strain/Species	Flank
genomic	68713	NCBI Gene Model \| MGI Sequence Detail	2399	C57BL/6J	± kb
transcript	NM_001112715	RefSeq \| MGI Sequence Detail	702	C57BL/6
polypeptide	Q9D103	UniProt \| EBI \| MGI Sequence Detail	106	Not Applicable

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UniProt

1 Sequence
InterPro Domains

IPR007593 CD225/Dispanin family

IPR051517 Interferon-induced transmembrane antiviral protein

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All nucleic 59

cDNA 53

Primer pair 6

Microarray probesets 4

Summaries

All 61

Developmental Gene Expression 13

Gene Ontology 9

Phenotypes 25
Earliest

J:65007 Cattanach BM, et al., Two imprinted gene mutations: three phenotypes. Hum Mol Genet. 2000 Sep 22;9(15):2263-73
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ifitm1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr69880	Chr7:140547270-140547275 (+)	-69 bp
Tssr69881	Chr7:140547290-140547301 (+)	-46 bp
Tssr69882	Chr7:140547947-140547960 (+)	612 bp
Tssr69883	Chr7:140547979-140548015 (+)	655 bp
Tssr69884	Chr7:140548025-140548066 (+)	704 bp
Tssr69885	Chr7:140548133-140548150 (+)	800 bp
Tssr69886	Chr7:140548151-140548169 (+)	818 bp
Tssr69887	Chr7:140548183-140548186 (+)	843 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24