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Ppp4r3a Gene Detail
Summary
  • Symbol
    Ppp4r3a
  • Name
    protein phosphatase 4 regulatory subunit 3A
  • Synonyms
    1110034C04Rik, Smek1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915984
    NCBI Gene: 68734
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:101005668-101049961 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 51.17 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    863 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915984
 protein coding gene Chr12:101005668-101051721 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020023
 protein coding gene Chr12:102535630-102588641 (-)
A/J MGP_AJ_G0019978
 protein coding gene Chr12:98672370-98716614 (-)
AKR/J MGP_AKRJ_G0019954
 protein coding gene Chr12:101368634-101412855 (-)
BALB/cJ MGP_BALBcJ_G0019964
 protein coding gene Chr12:99029110-99076474 (-)
C3H/HeJ MGP_C3HHeJ_G0019766
 protein coding gene Chr12:101901149-101945490 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020413
 protein coding gene Chr12:105704872-105749141 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018028
 protein coding gene Chr12:95659084-95704099 (-)
CAST/EiJ MGP_CASTEiJ_G0019312
 protein coding gene Chr12:97024028-97074463 (-)
CBA/J MGP_CBAJ_G0019738
 protein coding gene Chr12:109618271-109672875 (-)
DBA/2J MGP_DBA2J_G0019849
 protein coding gene Chr12:98125883-98170914 (-)
FVB/NJ MGP_FVBNJ_G0019838
 protein coding gene Chr12:96843947-96891421 (-)
LP/J MGP_LPJ_G0019925
 protein coding gene Chr12:102384884-102433827 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019880
 protein coding gene Chr12:113193543-113239960 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020442
 protein coding gene Chr12:100944702-100988949 (-)
PWK/PhJ MGP_PWKPhJ_G0019076
 protein coding gene Chr12:92770692-92815617 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018872
 protein coding gene Chr12:95127401-95172543 (-)
WSB/EiJ MGP_WSBEiJ_G0019366
 protein coding gene Chr12:101809536-101857002 (-)



Homology
more
  • Human Ortholog
    PPP4R3A, protein phosphatase 4 regulatory subunit 3A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PPP4R3A, protein phosphatase 4 regulatory subunit 3A
  • Synonyms
    FLFL1, KIAA2010, MSTP033, PP4R3, PP4R3A, SMEK1, smk-1, smk1
  • Links
    NCBI Gene ID: 55671
    neXtProt AC: NX_Q6IN85
    UniProt: Q6IN85

  • Chr Location
    14q32.12; chr14:91457508-91510554 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional allele exhibit increased anxiety- and depression-related behaviors with decreased miniature excitatory postsynaptic currents, decreased glutamate release, and decreased dendritic spine density.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    18
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    714
  • Tissues
    7
  • cDNA Data
    15
  • Literature Summary
    6
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000041846 Ensembl Gene Model | MGI Sequence Detail 44294 C57BL/6J ±  kb
transcript ENSMUST00000163095 Ensembl | MGI Sequence Detail 4083 Not Applicable  
polypeptide ENSMUSP00000129654 Ensembl | MGI Sequence Detail 833 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000015281 serine/threonine-protein phosphatase 4 regulatory subunit 3A
    (term hierarchy)
  • InterPro Domains
    IPR011989 Armadillo-like helical
    IPR016024 Armadillo-type fold
    IPR011993 PH-like domain superfamily
    IPR051137 Serine/threonine-protein phosphatase 4 regulatory subunit 3
    IPR006887 Serine/threonine-protein phosphatase 4 regulatory subunit 3-like, central domain
  • GlyGen
    Q6P2K6 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 18
    cDNA 17
    Primer pair 1

    Microarray probesets 7
Other
Accession IDs
less
MGI:3037543
References
more
  • Summaries
    All 40
    Developmental Gene Expression 6
    Gene Ontology 5
    Phenotypes 12
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:326388 Gao F, et al., Ppp4r3a deficiency leads to depression-like behaviors in mice by modulating the synthesis of synaptic proteins. Dis Model Mech. 2022 Jun 1;15(6):dmm049374
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory