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Ppil1 Gene Detail
Summary
  • Symbol
    Ppil1
  • Name
    peptidylprolyl isomerase (cyclophilin)-like 1
  • Synonyms
    1110060O10Rik, Cypl1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916066
    NCBI Gene: 68816
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:29469809-29482945 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 15.15 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    620 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916066
 protein coding gene Chr17:29469777-29483160 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023460
 protein coding gene Chr17:28765280-28778983 (-)
A/J MGP_AJ_G0023418
 protein coding gene Chr17:27761268-27774954 (-)
AKR/J MGP_AKRJ_G0023383
 protein coding gene Chr17:28009367-28023053 (-)
BALB/cJ MGP_BALBcJ_G0023423
 protein coding gene Chr17:28045113-28058816 (-)
C3H/HeJ MGP_C3HHeJ_G0023184
 protein coding gene Chr17:28394992-28409765 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023865
 protein coding gene Chr17:29910741-29925752 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021340
 protein coding gene Chr17:25107090-25120498 (-)
CAST/EiJ MGP_CASTEiJ_G0022685
 protein coding gene Chr17:28373620-28387095 (-)
CBA/J MGP_CBAJ_G0023159
 protein coding gene Chr17:31018457-31032143 (-)
DBA/2J MGP_DBA2J_G0023289
 protein coding gene Chr17:27308847-27322550 (-)
FVB/NJ MGP_FVBNJ_G0023259
 protein coding gene Chr17:27144344-27160264 (-)
LP/J MGP_LPJ_G0023367
 protein coding gene Chr17:29017194-29030897 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023277
 protein coding gene Chr17:30365132-30379285 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023907
 protein coding gene Chr17:28469040-28486999 (-)
PWK/PhJ MGP_PWKPhJ_G0022435
 protein coding gene Chr17:26145910-26162428 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022253
 protein coding gene Chr17:26453929-26471053 (-)
WSB/EiJ MGP_WSBEiJ_G0022747
 protein coding gene Chr17:28428665-28444217 (-)



Homology
more
  • Human Ortholog
    PPIL1, peptidylprolyl isomerase like 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PPIL1, peptidylprolyl isomerase like 1
  • Synonyms
    CGI-124, CYPL1, hCyPX, PCH14, PPIase
  • Links
    NCBI Gene ID: 51645
    neXtProt AC: NX_Q9Y3C6
    UniProt: Q9Y3C6

  • Chr Location
    6p21.2; chr6:36854827-36874803 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with Ppil1 mouse models; 1 with human PPIL1 associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 5 alleles in 6 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout is early embryonic lethal. Certain point mutations cause microcephaly, owing to reduced cerebral size, and are perinatal lethal.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    968
  • Tissues
    40
  • cDNA Data
    66
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 68816 NCBI Gene Model | MGI Sequence Detail 13137 C57BL/6J ±  kb
    transcript NM_026845 RefSeq | MGI Sequence Detail 1215 C57BL/6  
    polypeptide Q9D0W5 UniProt | EBI | MGI Sequence Detail 166 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000013083 peptidyl-prolyl cis-trans isomerase-like 1
      (term hierarchy)
    • EC
      5.2.1.8
    • InterPro Domains
      IPR029000 Cyclophilin-like domain superfamily
      IPR024936 Cyclophilin-type peptidyl-prolyl cis-trans isomerase
      IPR020892 Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site
      IPR044666 Cyclophilin-type peptidyl-prolyl cis-trans isomerase, cyclophilin A-like
      IPR002130 Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain
    Molecular
    Reagents
    less
    • All nucleic 67
      cDNA 67

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2146832
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 7
      Phenotypes 13
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory