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Tulp4 Gene Detail
Summary
  • Symbol
    Tulp4
  • Name
    TUB like protein 4
  • Synonyms
    1110057P05Rik, 2210038L17Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916092
    NCBI Gene: 68842
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:6156528-6290912 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 3.72 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2972 from dbSNP Build 142
  • Strain Annotations
    14
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916092
 protein coding gene Chr17:6156528-6301403 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023111
 protein coding gene Chr17:3270100-3416684 (+)
A/J MGP_AJ_G0023081
 protein coding gene Chr17:3192446-3321026 (+)
AKR/J MGP_AKRJ_G0023047
 protein coding gene Chr17:3269933-3422871 (+)
BALB/cJ MGP_BALBcJ_G0023084
 protein coding gene Chr17:3162697-3299061 (+)
C3H/HeJ MGP_C3HHeJ_G0022844
 protein coding gene Chr17:3304057-3454264 (+)
C57BL/6NJ no annotation
CAROLI/EiJ MGP_CAROLIEiJ_G0021029
 protein coding gene Chr17:2972381-3111974 (+)
CAST/EiJ MGP_CASTEiJ_G0022362
 protein coding gene Chr17:3316676-3563574 (+)
CBA/J no annotation
DBA/2J no annotation
FVB/NJ no annotation
LP/J MGP_LPJ_G0023014
 protein coding gene Chr17:3412569-3538549 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022940
 protein coding gene Chr17:3425782-3569031 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023548
 protein coding gene Chr17:3303767-3476255 (+)
PWK/PhJ MGP_PWKPhJ_G0022106
 protein coding gene Chr17:3122300-3526450 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021934
 protein coding gene Chr17:3230813-3377944 (+)
WSB/EiJ MGP_WSBEiJ_G0022412
 protein coding gene Chr17:3264857-3909782 (+)



Homology
more
  • Human Ortholog
    TULP4, TUB like protein 4
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TULP4, TUB like protein 4
  • Synonyms
    TUSP
  • Links
    NCBI Gene ID: 56995
    neXtProt AC: NX_Q9NRJ4
    UniProt: Q9NRJ4

  • Chr Location
    6q25.3; chr6:158232195-158511828 (+)  GRCh38
Human Diseases
less
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    40 phenotypes from 2 alleles in 2 genetic backgrounds
    362 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit perinatal lethality and multiple malformations during embryonic development, including severe cardiovascular and endo-/exocrine gland defects. Heterozygotes have developmental defects in several organ systems but show normal survival and a trend for increased body weight in adulthood.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    2
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    814
  • Tissues
    20
  • cDNA Data
    26
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 68842 NCBI Gene Model | MGI Sequence Detail 134385 C57BL/6J ±  kb
    transcript NM_054040 RefSeq | MGI Sequence Detail 9714 C57BL/6  
    polypeptide Q9JIL5 UniProt | EBI | MGI Sequence Detail 1547 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 29
      cDNA 26
      Primer pair 2
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1925896
    References
    more
    • Summaries
      All 388
      Developmental Gene Expression 4
      Diseases 6
      Gene Ontology 2
      Phenotypes 362
    • Earliest
      J:30229 Davisson MT, et al., Segmental trisomy as a mouse model for Down syndrome. Prog Clin Biol Res. 1993;384:117-33
    • Latest
      J:354984 Emili M, et al., Reversal of neurodevelopmental impairment and cognitive enhancement by pharmacological intervention with the polyphenol polydatin in a Down syndrome model. Neuropharmacology. 2024 Sep 27;261:110170
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory