Rnf208 MGI Mouse Gene Detail - MGI:1916096

Symbol

Rnf208
Name

ring finger protein 208
Synonyms

1110061N23Rik

Feature Type

protein coding gene
IDs

MGI:1916096
NCBI Gene: 68846
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr2:25132941-25134273 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 17.10 cM
Mapping Data

1 experiment

SNPs within 2kb

90 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1916096	protein coding gene	Chr2:25132941-25134274 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025430	protein coding gene	Chr2:23110053-23112060 (+)
A/J	MGP_AJ_G0025407	protein coding gene	Chr2:22221645-22223652 (+)
AKR/J	MGP_AKRJ_G0025377	protein coding gene	Chr2:22963544-22965551 (+)
BALB/cJ	MGP_BALBcJ_G0025403	protein coding gene	Chr2:22331494-22333501 (+)
C3H/HeJ	MGP_C3HHeJ_G0025164	protein coding gene	Chr2:22891763-22893770 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025847	protein coding gene	Chr2:23841679-23843686 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023258	protein coding gene	Chr2:21139431-21141443 (+)
CAST/EiJ	MGP_CASTEiJ_G0024627	protein coding gene	Chr2:22774458-22776465 (+)
CBA/J	MGP_CBAJ_G0025142	protein coding gene	Chr2:24681536-24683543 (+)
DBA/2J	MGP_DBA2J_G0025275	protein coding gene	Chr2:22064281-22066270 (+)
FVB/NJ	MGP_FVBNJ_G0025237	protein coding gene	Chr2:21804148-21806155 (+)
LP/J	MGP_LPJ_G0025361	protein coding gene	Chr2:23053106-23055113 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025268	protein coding gene	Chr2:24883624-24885631 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025906	protein coding gene	Chr2:22911668-22913675 (+)
PWK/PhJ	MGP_PWKPhJ_G0024375	protein coding gene	Chr2:21875547-21877554 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024175	protein coding gene	Chr2:23065609-23067616 (+)
WSB/EiJ	MGP_WSBEiJ_G0024696	protein coding gene	Chr2:22980158-22983386 (+)

Human Ortholog

RNF208, ring finger protein 208

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RNF208, ring finger protein 208
Links

HGNC:25420

NCBI Gene ID: 727800

neXtProt AC: NX_Q9H0X6

UniProt: Q9H0X6
Chr Location

chr9:137220247-137223408 (-) GRCh38

MGI Vertebrate Homology

Rnf208 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RNF208
Gene Tree

Rnf208

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Phenotype Summary

16 phenotypes from 1 allele in 1 genetic background
4 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

2
Endonuclease-mediated

2
Find Mice (IMSR)

9 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

11
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

788
Tissues

10
cDNA Data

4
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rnf208

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All Sequences

33
RefSeq

2
UniProt

1
CCDS

CCDS15757.2

Ensembl

ENSMUSG00000044628 (Evidence)
NCBI Gene

68846

			Length	Strain/Species	Flank
genomic	68846	NCBI Gene Model \| MGI Sequence Detail	1333	C57BL/6J	± kb
transcript	NM_176834	RefSeq \| MGI Sequence Detail	1351	C57BL/6
polypeptide	Q8K0W3	UniProt \| EBI \| MGI Sequence Detail	265	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000014118 RING finger protein 208

(term hierarchy)
InterPro Domains

IPR051435 RING finger E3 ubiquitin-protein ligases

IPR040100 RING finger protein 208, HC type RING finger

IPR013083 Zinc finger, RING/FYVE/PHD-type

IPR001841 Zinc finger, RING-type

IPR017907 Zinc finger, RING-type, conserved site

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All nucleic 4

cDNA 4

Microarray probesets 3

Summaries

All 24

Developmental Gene Expression 1

Gene Ontology 4

Phenotypes 4
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Rnf208:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr16669	Chr2:25131591-25131608 (+)	-1,341 bp
Tssr16670	Chr2:25131915-25131938 (+)	-1,014 bp
Tssr16671	Chr2:25132208-25132219 (+)	-727 bp
Tssr16672	Chr2:25132239-25132296 (+)	-673 bp
Tssr16673	Chr2:25132297-25132391 (+)	-597 bp
Tssr16674	Chr2:25132409-25132420 (+)	-526 bp
Tssr16675	Chr2:25133071-25133099 (+)	144 bp
Tssr16676	Chr2:25133250-25133261 (+)	315 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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