Rnf122 MGI Mouse Gene Detail - MGI:1916117

Symbol

Rnf122
Name

ring finger protein 122
Synonyms

1110063C11Rik

Feature Type

protein coding gene
IDs

MGI:1916117
NCBI Gene: 68867
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr8:31601848-31621510 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 17.97 cM
Mapping Data

1 experiment

SNPs within 2kb

792 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1916117	protein coding gene	Chr8:31601848-31623346 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033513	protein coding gene	Chr8:29492301-29513006 (+)
A/J	MGP_AJ_G0033493	protein coding gene	Chr8:28335943-28355960 (+)
AKR/J	MGP_AKRJ_G0033417	protein coding gene	Chr8:29264154-29284127 (+)
BALB/cJ	MGP_BALBcJ_G0033489	protein coding gene	Chr8:28482998-28505459 (+)
C3H/HeJ	MGP_C3HHeJ_G0033203	protein coding gene	Chr8:29561428-29583249 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034005	protein coding gene	Chr8:30568502-30589159 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030955	protein coding gene	Chr8:25220610-25240607 (+)
CAST/EiJ	MGP_CASTEiJ_G0032528	protein coding gene	Chr8:28943693-28965119 (+)
CBA/J	MGP_CBAJ_G0033179	protein coding gene	Chr8:31807708-31829986 (+)
DBA/2J	MGP_DBA2J_G0033332	protein coding gene	Chr8:28335863-28355800 (+)
FVB/NJ	MGP_FVBNJ_G0033277	protein coding gene	Chr8:28055309-28075907 (+)
LP/J	MGP_LPJ_G0033422	protein coding gene	Chr8:29440979-29463100 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033319	protein coding gene	Chr8:31392077-31412853 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034024	protein coding gene	Chr8:29273365-29300468 (+)
PWK/PhJ	MGP_PWKPhJ_G0032240	protein coding gene	Chr8:27849809-27871774 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032073	protein coding gene	Chr8:28620404-28640442 (+)
WSB/EiJ	MGP_WSBEiJ_G0032644	protein coding gene	Chr8:29444947-29469348 (+)

Human Ortholog

RNF122, ring finger protein 122

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RNF122, ring finger protein 122
Links

HGNC:21147

NCBI Gene ID: 79845

neXtProt AC: NX_Q9H9V4

UniProt: Q9H9V4
Chr Location

8p12; chr8:33547754-33567128 (-) GRCh38

MGI Vertebrate Homology

Rnf122 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RNF122
Gene Tree

Rnf122

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Phenotype Summary

9 phenotypes from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

3
Gene trapped

1
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

15 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele display decreased susceptibility to Riboviria infection induced morbidity/mortality with altered expression of interferons and interleukin 6.

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All GO Annotations

16
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

708
Tissues

2
cDNA Data

13
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

50
RefSeq

8
UniProt

2
CCDS

CCDS22220.1, CCDS90381.1

Ensembl

ENSMUSG00000039328 (Evidence)
NCBI Gene

68867

			Length	Strain/Species	Flank
genomic	ENSMUSG00000039328	Ensembl Gene Model \| MGI Sequence Detail	19663	C57BL/6J	± kb
transcript	ENSMUST00000217278	Ensembl \| MGI Sequence Detail	1726	Not Applicable
polypeptide	ENSMUSP00000150893	Ensembl \| MGI Sequence Detail	155	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000014075 RING finger protein 122

(term hierarchy)
InterPro Domains

IPR050731 HRD1 family E3 ubiquitin-protein ligases

IPR013083 Zinc finger, RING/FYVE/PHD-type

IPR001841 Zinc finger, RING-type

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All nucleic 13

cDNA 13

Microarray probesets 3

Summaries

All 29

Developmental Gene Expression 1

Gene Ontology 4

Phenotypes 6
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034

TSS for Rnf122:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr2536	Chr8:31601621-31601642 (+)	-216 bp
Tssr76798	Chr8:31601817-31601827 (+)	-26 bp
Tssr76799	Chr8:31601844-31601919 (+)	34 bp
Tssr76800	Chr8:31601924-31601935 (+)	82 bp
Tssr76801	Chr8:31605066-31605091 (+)	3,231 bp
Tssr76802	Chr8:31605120-31605131 (+)	3,278 bp
Tssr76803	Chr8:31619430-31619440 (+)	17,587 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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