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Ak8 Gene Detail
Summary
  • Symbol
    Ak8
  • Name
    adenylate kinase 8
  • Synonyms
    1190002A17Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916120
    NCBI Gene: 68870
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:28590176-28703177 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 19.38 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    3074 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916120
 protein coding gene Chr2:28588287-28703177 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025531
 protein coding gene Chr2:26777372-26899110 (+)
A/J MGP_AJ_G0025508
 protein coding gene Chr2:25753831-25870040 (+)
AKR/J MGP_AKRJ_G0025478
 protein coding gene Chr2:26605754-26722309 (+)
BALB/cJ MGP_BALBcJ_G0025504
 protein coding gene Chr2:25874584-25990633 (+)
C3H/HeJ MGP_C3HHeJ_G0025265
 protein coding gene Chr2:26528191-26647602 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025948
 protein coding gene Chr2:27671691-27789320 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023358
 protein coding gene Chr2:24571215-24686757 (+)
CAST/EiJ MGP_CASTEiJ_G0024728
 protein coding gene Chr2:26434112-26557838 (+)
CBA/J MGP_CBAJ_G0025243
 protein coding gene Chr2:28600634-28737675 (+)
DBA/2J MGP_DBA2J_G0025376
 protein coding gene Chr2:25564122-25678638 (+)
FVB/NJ MGP_FVBNJ_G0025338
 protein coding gene Chr2:25351235-25470616 (+)
LP/J MGP_LPJ_G0025462
 protein coding gene Chr2:26723537-26840230 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025369
 protein coding gene Chr2:28626806-28746499 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026007
 protein coding gene Chr2:26524999-26644487 (+)
PWK/PhJ MGP_PWKPhJ_G0024475
 protein coding gene Chr2:25372692-25490693 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024275
 protein coding gene Chr2:26655582-26775125 (+)
WSB/EiJ MGP_WSBEiJ_G0024797
 protein coding gene Chr2:26659947-26777840 (+)



Homology
more
  • Human Ortholog
    AK8, adenylate kinase 8
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AK8, adenylate kinase 8
  • Synonyms
    AK 8, C9orf98, DDX31
  • Links
    NCBI Gene ID: 158067
    neXtProt AC: NX_Q96MA6
    UniProt: Q96MA6

  • Chr Location
    9q34.13; chr9:132725578-132879046 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Ak8 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap insertion exhibit mild hydrocephalus, dilation of the lateral brain ventricles and reduced size of the hippocampus.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    16
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026807 Ensembl Gene Model | MGI Sequence Detail 113002 C57BL/6J ±  kb
    transcript ENSMUST00000074156 Ensembl | MGI Sequence Detail 1567 Not Applicable  
    polypeptide ENSMUSP00000073789 Ensembl | MGI Sequence Detail 479 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 16

      Microarray probesets 3
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 9
      Phenotypes 6
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory