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Maf1 Gene Detail
Summary
  • Symbol
    Maf1
  • Name
    MAF1 homolog, negative regulator of RNA polymerase III
  • Synonyms
    1110068E11Rik, Maf1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916127
    NCBI Gene: 68877
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:76235494-76238578 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 35.75 cM, cytoband E1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    67 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916127
 protein coding gene Chr15:76235494-76238580 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021987
 protein coding gene Chr15:76422436-76425522 (+)
A/J MGP_AJ_G0021945
 protein coding gene Chr15:73639284-73642370 (+)
AKR/J MGP_AKRJ_G0021928
 protein coding gene Chr15:75640936-75644022 (+)
BALB/cJ MGP_BALBcJ_G0021954
 protein coding gene Chr15:73667015-73670101 (+)
C3H/HeJ MGP_C3HHeJ_G0021726
 protein coding gene Chr15:75682608-75685694 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022394
 protein coding gene Chr15:79275162-79278248 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019923
 protein coding gene Chr15:70299612-70302711 (+)
CAST/EiJ MGP_CASTEiJ_G0021245
 protein coding gene Chr15:76481300-76484379 (+)
CBA/J MGP_CBAJ_G0021693
 protein coding gene Chr15:81783433-81786519 (+)
DBA/2J MGP_DBA2J_G0021818
 protein coding gene Chr15:73175083-73178169 (+)
FVB/NJ MGP_FVBNJ_G0021799
 protein coding gene Chr15:72224991-72228077 (+)
LP/J MGP_LPJ_G0021889
 protein coding gene Chr15:76512784-76515870 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021823
 protein coding gene Chr15:87120009-87123088 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022414
 protein coding gene Chr15:75880866-75883945 (+)
PWK/PhJ MGP_PWKPhJ_G0020986
 protein coding gene Chr15:73333162-73336248 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020826
 protein coding gene Chr15:75602155-75605241 (+)
WSB/EiJ MGP_WSBEiJ_G0021297
 protein coding gene Chr15:75983772-75986858 (+)



Homology
more
  • Human Ortholog
    MAF1, MAF1 homolog, negative regulator of RNA polymerase III
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAF1, MAF1 homolog, negative regulator of RNA polymerase III
  • Links
    NCBI Gene ID: 84232
    neXtProt AC: NX_Q9H063
    UniProt: Q9H063

  • Chr Location
    8q24.3; chr8:144104420-144107611 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 1 allele in 1 genetic background
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit slow postnatal weight gain, reduced fertility, decreased food intake, decreased susceptibility to hepatic steatosis and diet-induced obesity, increased energy expenditure, altered lipid homeostasis, high levels of amino acids and spermidine, and an extended life span.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    27
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    720
  • Tissues
    13
  • cDNA Data
    149
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 68877 NCBI Gene Model | MGI Sequence Detail 3085 C57BL/6J ±  kb
    transcript NM_001164607 RefSeq | MGI Sequence Detail 1749 C57BL/6  
    polypeptide Q9D0U6 UniProt | EBI | MGI Sequence Detail 258 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000010046 repressor of RNA polymerase III transcription MAF1
      (term hierarchy)
    • InterPro Domains
      IPR015257 Repressor of RNA polymerase III transcription Maf1
      IPR038564 Repressor of RNA polymerase III transcription Maf1 superfamily
    Molecular
    Reagents
    less
    • All nucleic 150
      cDNA 150

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2146154
    References
    more
    • Summaries
      All 67
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 8
      Phenotypes 32
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:350727 Han Y, et al., Maf1 loss regulates spinogenesis and attenuates cognitive impairment in Alzheimer's disease. Brain. 2024 Jun 3;147(6):2128-2143
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory