Zfas1 MGI Mouse Gene Detail - MGI:1916199 - zinc finger, NFX1-type containing 1, antisense RNA 1

Symbol

Zfas1
Name

zinc finger, NFX1-type containing 1, antisense RNA 1
Synonyms

1500012F01Rik, Zfos1

Feature Type

lncRNA gene
IDs

MGI:1916199
NCBI Gene: 68949
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr2:166904854-166907782 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 87.22 cM
Mapping Data

1 experiment

SNPs within 2kb

144 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1916199	lncRNA gene	Chr2:166904854-166907783 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026908	protein coding gene	Chr2:172762489-172765211 (+)
A/J	MGP_AJ_G0026875	protein coding gene	Chr2:165666915-165669843 (+)
AKR/J	MGP_AKRJ_G0026846	protein coding gene	Chr2:170597885-170600747 (+)
BALB/cJ	MGP_BALBcJ_G0026884	protein coding gene	Chr2:166015839-166019016 (+)
C3H/HeJ	MGP_C3HHeJ_G0026626	protein coding gene	Chr2:170966071-170970195 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027331	protein coding gene	Chr2:177780901-177785879 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024702	protein coding gene	Chr2:158994733-158997752 (+)
CAST/EiJ	MGP_CASTEiJ_G0026084	protein coding gene	Chr2:171424638-171427361 (+)
CBA/J	MGP_CBAJ_G0026603	protein coding gene	Chr2:184303199-184307893 (+)
DBA/2J	MGP_DBA2J_G0026741	protein coding gene	Chr2:164787822-164790987 (+)
FVB/NJ	MGP_FVBNJ_G0026707	protein coding gene	Chr2:163293498-163296552 (+)
LP/J	MGP_LPJ_G0026842	protein coding gene	Chr2:172786325-172789047 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026726	protein coding gene	Chr2:187706094-187709816 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027388	protein coding gene	Chr2:170506557-170509485 (+)
PWK/PhJ	MGP_PWKPhJ_G0025821	protein coding gene	Chr2:164440768-164443488 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025622	protein coding gene	Chr2:169455227-169457925 (+)
WSB/EiJ	MGP_WSBEiJ_G0026157	protein coding gene	Chr2:171408616-171411338 (+)

Human Ortholog

ZFAS1, ZNFX1 antisense RNA 1

Vertebrate Orthologs

1

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ZFAS1, ZNFX1 antisense RNA 1
Synonyms

C20orf199, HSUP1, HSUP2, NCRNA00275, ZNFX1-AS1
Links

HGNC:33101

NCBI Gene ID: 441951
Chr Location

20q13.13; chr20:49278178-49299600 (+) GRCh38

MGI Vertebrate Homology

Zfas1 stringent orthology
1 human;1 mouse
HCOP

vertebrate homology predictions: ZFAS1
Gene Tree

Zfas1

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

53
Endonuclease-mediated

1
Gene trapped

52
Incidental Mutations

APF
Find Mice (IMSR)

38 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

18
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

39

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas

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All Sequences

43
RefSeq

1
UniProt

1
CCDS

CCDS38338.1

Ensembl

ENSMUSG00000074578 (Evidence)
NCBI Gene

68949

			Length	Strain/Species	Flank
genomic	68949	NCBI Gene Model \| MGI Sequence Detail	2929	C57BL/6J	± kb
transcript	NR_138563	RefSeq \| MGI Sequence Detail	754	C57BL/6
polypeptide	Q3V494	UniProt \| EBI \| MGI Sequence Detail	79	Not Applicable

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UniProt

1 Sequence

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All nucleic 39

cDNA 39

Microarray probesets 3

Summaries

All 22

Gene Ontology 3

Phenotypes 6
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:294533 Jiao L, et al., lncRNA-ZFAS1 induces mitochondria-mediated apoptosis by causing cytosolic Ca(2+) overload in myocardial infarction mice model. Cell Death Dis. 2019 Dec 9;10(12):942

TSS for Zfas1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr21787	Chr2:166903190-166903209 (+)	-1,654 bp
Tssr21788	Chr2:166903211-166903222 (+)	-1,637 bp
Tssr21789	Chr2:166904735-166904774 (+)	-99 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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