Dcaf12 MGI Mouse Gene Detail - MGI:1916220 - DDB1 and CUL4 associated factor 12

Symbol

Dcaf12
Name

DDB1 and CUL4 associated factor 12
Synonyms

1500001L20Rik, 5830424K06Rik, Wdr40a

Feature Type

protein coding gene
IDs

MGI:1916220
NCBI Gene: 68970
Alliance

genome feature page
Transcription Start Sites

7 TSS

Sequence Map

Chr4:41291300-41314889 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 21.32 cM, cytoband B1
Mapping Data

3 experiments

SNPs within 2kb

537 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1916220	protein coding gene	Chr4:41291300-41316749 (-)
129S1/SvImJ	ENSMUSG00200004591	protein coding gene	Chr4:38133460-38157046 (-)
A/J	ENSMUSG00195002751	protein coding gene	Chr4:38509339-38532925 (-)
AKR/J	ENSMUSG00220033762	protein coding gene	Chr4:38337383-38360957 (-)
BALB/cJ	ENSMUSG00180021503	protein coding gene	Chr4:38096130-38119718 (-)
C3H/HeJ	ENSMUSG00175021195	protein coding gene	Chr4:38474771-38498354 (-)
C57BL/6NJ	ENSMUSG00215025609	protein coding gene	Chr4:38112407-38135999 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025910	protein coding gene	Chr4:35389791-35412817 (-)
CAST/EiJ	ENSTCUG00005003840	protein coding gene	Chr4:37972573-37996149 (-)
CBA/J	ENSMUSG00210007406	protein coding gene	Chr4:38175687-38199270 (-)
DBA/2J	ENSMUSG00185006485	protein coding gene	Chr4:38249452-38273035 (-)
FVB/NJ	ENSMUSG00205017107	protein coding gene	Chr4:37800255-37823839 (-)
JF1/MsJ	ENSUMUG00000015741	protein coding gene	Chr4:38192611-38216589 (-)
LP/J	ENSMUSG00230041925	protein coding gene	Chr4:41627027-41650611 (-)
NOD/ShiLtJ	ENSMUSG00190004967	protein coding gene	Chr4:38198640-38222214 (-)
NZO/HlLtJ	ENSMUSG00225005997	protein coding gene	Chr4:45507643-45531218 (-)
PWK/PhJ	ENSLUMG00010006087	protein coding gene	Chr4:37749880-37773843 (-)
SPRET/EiJ	ENSMSPG00010023043	protein coding gene	Chr4:38701659-38723567 (-)
WSB/EiJ	ENSIUOG00005047639	protein coding gene	Chr4:38053052-38076791 (-)

Human Ortholog

DCAF12, DDB1 and CUL4 associated factor 12

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DCAF12, DDB1 and CUL4 associated factor 12
Synonyms

CT102, KIAA1892, TCC52, WDR40A
Links

HGNC:19911

NCBI Gene ID: 25853

UniProt: Q5T6F0
Chr Location

9p13.3; chr9:34086384-34127399 (-) GRCh38

MGI Vertebrate Homology

Dcaf12 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DCAF12
Gene Tree

Dcaf12

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

33
Chemically and radiation induced

1
Endonuclease-mediated

4
Gene trapped

26
Targeted

2
Genomic Mutations

1 involving Dcaf12
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

29 strains or lines available

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All GO Annotations

29
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

603
Tissues

6
cDNA Data

159
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dcaf12

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All Sequences

57
RefSeq

14
UniProt

1
CCDS

CCDS18059.1

Ensembl

ENSMUSG00000028436 (Evidence)
NCBI Gene

68970

			Length	Strain/Species	Flank
genomic	ENSMUSG00000028436	Ensembl Gene Model \| MGI Sequence Detail	23590	C57BL/6J	± kb
transcript	ENSMUST00000030145	Ensembl \| MGI Sequence Detail	3442	Not Applicable
polypeptide	ENSMUSP00000030145	Ensembl \| MGI Sequence Detail	453	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000031546 DDB1- and CUL4-associated factor 12

(term hierarchy)
InterPro Domains

IPR056151 DDB1- and CUL4-associated factor 12, beta-propeller domain

IPR051191 DDB1-CUL4-associated factor 12

IPR001680 WD40 repeat

IPR019775 WD40 repeat, conserved site

IPR036322 WD40-repeat-containing domain superfamily

IPR015943 WD40/YVTN repeat-like-containing domain superfamily

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All nucleic 162

cDNA 161

Primer pair 1

Microarray probesets 8

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MGI:1923288, MGI:2140155, MGI:2140386

Summaries

All 44

Developmental Gene Expression 1

Gene Ontology 6

Phenotypes 12
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Dcaf12:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr41331	Chr4:41314877-41314889 (-)	6 bp
Tssr41330	Chr4:41314814-41314859 (-)	52 bp
Tssr41329	Chr4:41314797-41314802 (-)	89 bp
Tssr41328	Chr4:41314778-41314787 (-)	106 bp
Tssr41327	Chr4:41314727-41314758 (-)	146 bp
Tssr41326	Chr4:41314706-41314723 (-)	174 bp
Tssr41325	Chr4:41313902-41313914 (-)	981 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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