Zfp580 MGI Mouse Gene Detail - MGI:1916242

Symbol

Zfp580
Name

zinc finger protein 580
Synonyms

1500015O20Rik

Feature Type

protein coding gene
IDs

MGI:1916242
NCBI Gene: 68992
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr7:5054537-5056722 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 2.92 cM
Mapping Data

2 experiments

SNPs within 2kb

104 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1916242	protein coding gene	Chr7:5041682-5056722 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0031580	protein coding gene	Chr7:2017344-2019534 (+)
A/J	MGP_AJ_G0031554	protein coding gene	Chr7:2014466-2016657 (+)
AKR/J	MGP_AKRJ_G0031483	protein coding gene	Chr7:2092045-2094235 (+)
BALB/cJ	MGP_BALBcJ_G0031562	protein coding gene	Chr7:2052884-2055074 (+)
C3H/HeJ	MGP_C3HHeJ_G0031283	protein coding gene	Chr7:2068284-2070474 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0032023	protein coding gene	Chr7:2087428-2089618 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029147	protein coding gene	Chr7:1728450-1730646 (+)
CAST/EiJ	MGP_CASTEiJ_G0030647	protein coding gene	Chr7:2005121-2007309 (+)
CBA/J	MGP_CBAJ_G0031241	protein coding gene	Chr7:2298557-2300747 (+)
DBA/2J	MGP_DBA2J_G0031400	protein coding gene	Chr7:1984556-1986746 (+)
FVB/NJ	MGP_FVBNJ_G0031352	protein coding gene	Chr7:1938817-1941007 (+)
LP/J	MGP_LPJ_G0031485	protein coding gene	Chr7:2113674-2115864 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031391	protein coding gene	Chr7:2248525-2250715 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032053	protein coding gene	Chr7:1988402-1990592 (+)
PWK/PhJ	MGP_PWKPhJ_G0030375	protein coding gene	Chr7:2148617-2150808 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0030200	protein coding gene	Chr7:2033277-2035471 (+)
WSB/EiJ	MGP_WSBEiJ_G0030742	protein coding gene	Chr7:2003953-2006146 (+)

Human Ortholog

ZNF580, zinc finger protein 580

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ZNF580, zinc finger protein 580
Links

HGNC:29473

NCBI Gene ID: 51157

neXtProt AC: NX_Q9UK33

UniProt: Q9UK33
Chr Location

19q13.42; chr19:55635016-55643470 (+) GRCh38

MGI Vertebrate Homology

Zfp580 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: ZNF580
Gene Tree

Zfp580

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Gene trapped

4
Targeted

6
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

14 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

24
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

814
Tissues

76
cDNA Data

16
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

39
RefSeq

9
UniProt

2
CCDS

CCDS51982.1

Ensembl

ENSMUSG00000055633 (Evidence)
NCBI Gene

68992

			Length	Strain/Species	Flank
genomic	ENSMUSG00000055633	Ensembl Gene Model \| MGI Sequence Detail	2186	C57BL/6J	± kb
transcript	ENSMUST00000208570	Ensembl \| MGI Sequence Detail	693	Not Applicable
polypeptide	ENSMUSP00000147223	Ensembl \| MGI Sequence Detail	230	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000018002 zinc finger protein 580

(term hierarchy)
InterPro Domains

IPR050752 C2H2-type zinc-finger domain-containing protein

IPR036236 Zinc finger C2H2 superfamily

IPR013087 Zinc finger C2H2-type

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All nucleic 17

Genomic 1

cDNA 16

Microarray probesets 3

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MGI:2142036

Summaries

All 39

Developmental Gene Expression 5

Gene Ontology 4

Phenotypes 11
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Zfp580:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr64394	Chr7:5054466-5054475 (+)	-66 bp
Tssr64395	Chr7:5054484-5054495 (+)	-47 bp
Tssr64396	Chr7:5054499-5054510 (+)	-32 bp
Tssr64397	Chr7:5054514-5054556 (+)	-2 bp
Tssr64398	Chr7:5054562-5054600 (+)	44 bp
Tssr64399	Chr7:5054602-5054631 (+)	80 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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