Mcts1 MGI Mouse Gene Detail - MGI:1916245 - malignant T cell amplified sequence 1

Symbol

Mcts1
Name

malignant T cell amplified sequence 1
Synonyms

1500019M23Rik, MCT-1

Feature Type

protein coding gene
IDs

MGI:1916245
NCBI Gene: 68995
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

ChrX:37689455-37702303 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 22.88 cM, cytoband A2
Mapping Data

2 experiments

SNPs within 2kb

251 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1916245	protein coding gene	ChrX:37653682-37702401 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035667	protein coding gene	ChrX:33572409-33588448 (+)
A/J	MGP_AJ_G0035652	protein coding gene	ChrX:33622523-33640840 (+)
AKR/J	MGP_AKRJ_G0035569	protein coding gene	ChrX:34418101-34433010 (+)
BALB/cJ	MGP_BALBcJ_G0035636	protein coding gene	ChrX:33328427-33341867 (+)
C3H/HeJ	MGP_C3HHeJ_G0035340	protein coding gene	ChrX:33935747-33951674 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0036167	protein coding gene	ChrX:34341767-34360493 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0033019	protein coding gene	ChrX:32034495-32045225 (+)
CAST/EiJ	MGP_CASTEiJ_G0034631	protein coding gene	ChrX:21932185-21950396 (+)
CBA/J	MGP_CBAJ_G0035314	protein coding gene	ChrX:35209292-35225286 (+)
DBA/2J	MGP_DBA2J_G0035468	protein coding gene	ChrX:33462112-33474336 (+)
FVB/NJ	MGP_FVBNJ_G0035417	protein coding gene	ChrX:33211205-33224047 (+)
LP/J	MGP_LPJ_G0035556	protein coding gene	ChrX:33972175-33984791 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035455	protein coding gene	ChrX:35542508-35558965 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0036183	protein coding gene	ChrX:33617077-33633547 (+)
PWK/PhJ	MGP_PWKPhJ_G0034332	protein coding gene	ChrX:21514631-21527622 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0034177	protein coding gene	ChrX:22477792-22492406 (+)
WSB/EiJ	MGP_WSBEiJ_G0034777	protein coding gene	ChrX:33297936-33313837 (+)

Human Ortholog

MCTS1, MCTS1 re-initiation and release factor

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MCTS1, MCTS1 re-initiation and release factor
Synonyms

IMD118, MCT-1, MCT1
Links

HGNC:23357

NCBI Gene ID: 28985

neXtProt AC: NX_Q9ULC4

UniProt: Q9ULC4
Chr Location

Xq24; chrX:120594010-120621159 (+) GRCh38

MGI Vertebrate Homology

Mcts1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MCTS1
Protein SuperFamily

Tma_RNA-bind_prd
Gene Tree

Mcts1

Diseases

1 with human MCTS1 associations

				Human Disease	Mouse Models
				primary immunodeficiency disease IDs primary immunodeficiency disease DOID:612 ICD10CM:D84.9 ICD9CM:279.3 KEGG:05340 MESH:D007153 NCI:C39725 OMIM:242850 OMIM:PS300755 UMLS_CUI:C0021051

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

24
Endonuclease-mediated

2
Gene trapped

20
Targeted

2
Incidental Mutations

APF
Find Mice (IMSR)

15 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

16
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

716
Tissues

4
cDNA Data

63
Literature Summary

5

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mcts1

ZFIN mcts1

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All Sequences

49
RefSeq

15
UniProt

1
CCDS

CCDS30094.1

Ensembl

ENSMUSG00000000355 (Evidence)
NCBI Gene

68995

			Length	Strain/Species	Flank
genomic	ENSMUSG00000000355	Ensembl Gene Model \| MGI Sequence Detail	12849	C57BL/6J	± kb
transcript	ENSMUST00000000365	Ensembl \| MGI Sequence Detail	783	Not Applicable
polypeptide	ENSMUSP00000000365	Ensembl \| MGI Sequence Detail	181	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000010257 malignant T cell-amplified sequence 1

(term hierarchy)
InterPro Domains

IPR016437 MCT-1/Tma20

IPR041366 Pre-PUA domain

IPR002478 PUA domain

IPR015947 PUA-like superfamily

IPR004521 Uncharacterised domain CHP00451

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All nucleic 64

cDNA 63

Primer pair 1

Microarray probesets 3

Summaries

All 42

Developmental Gene Expression 5

Gene Ontology 6

Phenotypes 11
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Mcts1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr160788	ChrX:37689326-37689337 (+)	-123 bp
Tssr160789	ChrX:37689467-37689474 (+)	16 bp
Tssr160790	ChrX:37689503-37689568 (+)	81 bp
Tssr160791	ChrX:37689735-37689765 (+)	295 bp
Tssr160792	ChrX:37690086-37690151 (+)	664 bp
Tssr160793	ChrX:37696195-37696198 (+)	6,742 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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