Snx15 MGI Mouse Gene Detail - MGI:1916274

Symbol

Snx15
Name

sorting nexin 15
Synonyms

1500032B08Rik, E130013C21Rik

Feature Type

protein coding gene
IDs

MGI:1916274
NCBI Gene: 69024
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr19:6169429-6178334 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 4.34 cM
Mapping Data

2 experiments

SNPs within 2kb

298 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1916274	protein coding gene	Chr19:6169429-6182446 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0024750	protein coding gene	Chr19:3150034-3160210 (-)
A/J	MGP_AJ_G0024716	protein coding gene	Chr19:2982036-2990947 (-)
AKR/J	MGP_AKRJ_G0024689	protein coding gene	Chr19:3070019-3080836 (-)
BALB/cJ	MGP_BALBcJ_G0024716	protein coding gene	Chr19:2973718-2982695 (-)
C3H/HeJ	MGP_C3HHeJ_G0024484	protein coding gene	Chr19:3088796-3104132 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0025162	protein coding gene	Chr19:3210717-3219583 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022596	protein coding gene	Chr19:2907880-2916425 (-)
CAST/EiJ	MGP_CASTEiJ_G0023956	protein coding gene	Chr19:3100443-3109169 (-)
CBA/J	MGP_CBAJ_G0024456	protein coding gene	Chr19:3368645-3383434 (-)
DBA/2J	MGP_DBA2J_G0024583	protein coding gene	Chr19:2968957-2980187 (-)
FVB/NJ	MGP_FVBNJ_G0024549	protein coding gene	Chr19:2979731-2988666 (-)
LP/J	MGP_LPJ_G0024669	protein coding gene	Chr19:3126603-3135707 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024578	protein coding gene	Chr19:3187427-3196337 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025210	protein coding gene	Chr19:3100260-3109165 (-)
PWK/PhJ	MGP_PWKPhJ_G0023702	protein coding gene	Chr19:2998121-3007292 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0023507	protein coding gene	Chr19:3057364-3069127 (-)
WSB/EiJ	MGP_WSBEiJ_G0024018	protein coding gene	Chr19:3107473-3116382 (-)

Human Ortholog

SNX15, sorting nexin 15

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SNX15, sorting nexin 15
Synonyms

HSAF001435
Links

HGNC:14978

NCBI Gene ID: 29907

neXtProt AC: NX_Q9NRS6

UniProt: Q9NRS6
Chr Location

11q13.1; chr11:65027439-65040572 (+) GRCh38

MGI Vertebrate Homology

Snx15 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SNX15
Gene Tree

Snx15

less

Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Endonuclease-mediated

1
Gene trapped

11
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

25 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

less

All GO Annotations

13
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

758
Tissues

37
cDNA Data

40
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase snx15

ZFIN snx15

less

All Sequences

55
RefSeq

6
UniProt

5
CCDS

CCDS29495.1

Ensembl

ENSMUSG00000024787 (Evidence)
NCBI Gene

69024

			Length	Strain/Species	Flank
genomic	ENSMUSG00000024787	Ensembl Gene Model \| MGI Sequence Detail	8906	C57BL/6J	± kb
transcript	ENSMUST00000025702	Ensembl \| MGI Sequence Detail	1635	Not Applicable
polypeptide	ENSMUSP00000025702	Ensembl \| MGI Sequence Detail	337	Not Applicable

less

UniProt

5 Sequences
Protein Ontology

PR:000015364 sorting nexin-15

(term hierarchy)
InterPro Domains

IPR051866 Intracellular Signaling and Trafficking Protein

IPR007330 MIT domain

IPR036181 MIT domain superfamily

IPR001683 Phox homology

IPR036871 PX domain superfamily
GlyGen

Q91WE1 1 site, 1 O-linked glycan (1 site)

less

All nucleic 44

cDNA 43

Primer pair 1

Microarray probesets 2

less

MGI:2442017

Summaries

All 32

Developmental Gene Expression 2

Gene Ontology 5

Phenotypes 9
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Snx15:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr157836	Chr19:6178238-6178319 (-)	55 bp
Tssr157835	Chr19:6178174-6178221 (-)	136 bp
Tssr157834	Chr19:6177855-6177872 (-)	470 bp
Tssr157833	Chr19:6171887-6171922 (-)	6,429 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24