Zg16 MGI Mouse Gene Detail - MGI:1916286 - zymogen granule protein 16

Symbol

Zg16
Name

zymogen granule protein 16
Synonyms

1810010M01Rik

Feature Type

protein coding gene
IDs

MGI:1916286
NCBI Gene: 69036
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr7:126649328-126651847 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 69.30 cM, cytoband F4
Mapping Data

3 experiments

SNPs within 2kb

103 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1916286	protein coding gene	Chr7:126649328-126686500 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0033019	protein coding gene	Chr7:131365139-131367658 (-)
A/J	MGP_AJ_G0033002	protein coding gene	Chr7:127879604-127916954 (-)
AKR/J	MGP_AKRJ_G0032934	protein coding gene	Chr7:131114850-131160391 (-)
BALB/cJ	MGP_BALBcJ_G0033007	protein coding gene	Chr7:127541583-127579575 (-)
C3H/HeJ	MGP_C3HHeJ_G0032717	protein coding gene	Chr7:131055755-131093221 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0033513	protein coding gene	Chr7:136469551-136508728 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030485	protein coding gene	Chr7:129091370-129093879 (-)
CAST/EiJ	MGP_CASTEiJ_G0032046	protein coding gene	Chr7:122846829-122849348 (-)
CBA/J	MGP_CBAJ_G0032690	protein coding gene	Chr7:141058715-141108905 (-)
DBA/2J	MGP_DBA2J_G0032842	protein coding gene	Chr7:125852237-125890140 (-)
FVB/NJ	MGP_FVBNJ_G0032795	protein coding gene	Chr7:125702530-125740681 (-)
LP/J	MGP_LPJ_G0032936	protein coding gene	Chr7:132834314-132836833 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032827	protein coding gene	Chr7:142223600-142263674 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033532	protein coding gene	Chr7:130130226-130167167 (-)
PWK/PhJ	MGP_PWKPhJ_G0031753	protein coding gene	Chr7:118848975-118851494 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0031599	protein coding gene	Chr7:116970660-116973176 (-)
WSB/EiJ	MGP_WSBEiJ_G0032158	protein coding gene	Chr7:131105880-131108399 (-)

Human Ortholog

ZG16, zymogen granule protein 16

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ZG16, zymogen granule protein 16
Synonyms

JCLN, JCLN1, ZG16A
Links

HGNC:30961

NCBI Gene ID: 653808

neXtProt AC: NX_O60844

UniProt: O60844
Chr Location

16p11.2

MGI Vertebrate Homology

Zg16 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: ZG16
Gene Tree

Zg16

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References

3 with disease annotations

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
42 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

3
Targeted

6
Genomic Mutations

5 involving Zg16
Find Mice (IMSR)

9 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit increased bacterial penetrance into the inner mucus layer of the colon, increased bacterial loads in draining lymph nodes and the spleen and increased abdominal fat mass.

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All GO Annotations

18
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

255

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase zg16

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All Sequences

37
RefSeq

2
UniProt

3
CCDS

CCDS21856.1

Ensembl

ENSMUSG00000049350 (Evidence)
NCBI Gene

69036

			Length	Strain/Species	Flank
genomic	69036	NCBI Gene Model \| MGI Sequence Detail	2520	C57BL/6J	± kb
transcript	NM_026918	RefSeq \| MGI Sequence Detail	682	C57BL/6
polypeptide	Q8K0C5	UniProt \| EBI \| MGI Sequence Detail	167	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000017660 zymogen granule membrane protein 16

(term hierarchy)
InterPro Domains

IPR001229 Jacalin-like lectin domain

IPR036404 Jacalin-like lectin domain superfamily

IPR052321 Polyamine Binding and Protein Trafficking

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All nucleic 255

cDNA 255

Microarray probesets 4

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MGI:2142007

Summaries

All 69

Diseases 3

Gene Ontology 7

Phenotypes 42
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:349484 Henis M, et al., The autism susceptibility kinase, TAOK2, phosphorylates eEF2 and modulates translation. Sci Adv. 2024 Apr 12;10(15):eadf7001

TSS for Zg16:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr2403	Chr7:126651852-126651866 (-)	-12 bp
Tssr74938	Chr7:126651821-126651835 (-)	19 bp
Tssr74937	Chr7:126651120-126651159 (-)	707 bp
Tssr74936	Chr7:126650860-126650888 (-)	973 bp
Tssr74935	Chr7:126650837-126650858 (-)	999 bp
Tssr74934	Chr7:126649698-126649711 (-)	2,142 bp
Tssr74933	Chr7:126649494-126649512 (-)	2,344 bp
Tssr74932	Chr7:126649428-126649438 (-)	2,414 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24