Hapstr1 MGI Mouse Gene Detail - MGI:1916303 - HUWE1 associated protein modifying stress responses

Symbol

Hapstr1
Name

HUWE1 associated protein modifying stress responses
Synonyms

1110017P05Rik, 1810013L24Rik, 3010002C02Rik

Feature Type

protein coding gene
IDs

MGI:1916303
NCBI Gene: 69053
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr16:8647964-8676786 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 4.37 cM, cytoband A3
Mapping Data

3 experiments

SNPs within 2kb

551 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1916303	protein coding gene	Chr16:8647964-8676788 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022500	protein coding gene	Chr16:5516631-5549399 (+)
A/J	MGP_AJ_G0022462	protein coding gene	Chr16:5195461-5225638 (+)
AKR/J	MGP_AKRJ_G0022438	protein coding gene	Chr16:5484289-5518097 (+)
BALB/cJ	MGP_BALBcJ_G0022466	protein coding gene	Chr16:5360932-5389702 (+)
C3H/HeJ	MGP_C3HHeJ_G0022233	protein coding gene	Chr16:5522001-5555810 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022915	protein coding gene	Chr16:5688141-5719984 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020436	protein coding gene	Chr16:5396832-5426939 (+)
CAST/EiJ	MGP_CASTEiJ_G0021760	protein coding gene	Chr16:5548155-5585029 (+)
CBA/J	MGP_CBAJ_G0022202	protein coding gene	Chr16:5882833-5917344 (+)
DBA/2J	MGP_DBA2J_G0022333	protein coding gene	Chr16:5237749-5266339 (+)
FVB/NJ	MGP_FVBNJ_G0022309	protein coding gene	Chr16:5219801-5251040 (+)
LP/J	MGP_LPJ_G0022401	protein coding gene	Chr16:5484443-5515750 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022331	protein coding gene	Chr16:5667777-5698499 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022928	protein coding gene	Chr16:5431165-5462171 (+)
PWK/PhJ	MGP_PWKPhJ_G0021500	protein coding gene	Chr16:5419813-5448355 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021330	protein coding gene	Chr16:5481547-5537616 (+)
WSB/EiJ	MGP_WSBEiJ_G0021808	protein coding gene	Chr16:5473002-5503585 (+)

Human Ortholog

HAPSTR1, HUWE1 associated protein modifying stress responses

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HAPSTR1, HUWE1 associated protein modifying stress responses
Synonyms

C16orf72, PRO0149, TAPR1
Links

HGNC:30103

NCBI Gene ID: 29035

neXtProt AC: NX_Q14CZ0

UniProt: Q14CZ0
Chr Location

16p13.2; chr16:9091644-9121635 (+) GRCh38

MGI Vertebrate Homology

Hapstr1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: HAPSTR1
Gene Tree

Hapstr1

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Phenotype Summary

7 phenotypes from 2 alleles in 1 genetic background
1 phenotype from multigenic genotypes
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

46
Endonuclease-mediated

1
Gene trapped

43
Targeted

2
Incidental Mutations

APF
Find Mice (IMSR)

38 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice with loss of expression display lethality throughout fetal growth and development with reduced fetal size and impaired proliferation of MEFs.

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All GO Annotations

10
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

712
Tissues

5
cDNA Data

20
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN hapstr1a

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All Sequences

55
RefSeq

2
UniProt

3
CCDS

CCDS49756.1

Ensembl

ENSMUSG00000022507 (Evidence)
NCBI Gene

69053

			Length	Strain/Species	Flank
genomic	ENSMUSG00000022507	Ensembl Gene Model \| MGI Sequence Detail	28823	C57BL/6J	± kb
transcript	ENSMUST00000023150	Ensembl \| MGI Sequence Detail	4072	Not Applicable
polypeptide	ENSMUSP00000023150	Ensembl \| MGI Sequence Detail	275	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000059782 HUWE1-associated protein modifying stress responses 1

(term hierarchy)
InterPro Domains

IPR040308 HUWE1-associated protein modifying stress responses

IPR029196 HUWE1-associated protein modifying stress responses-like

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All nucleic 21

cDNA 21

Microarray probesets 11

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MGI:1919648, MGI:1923563, MGI:2146365, MGI:2146624, MGI:2146733, MGI:7384676

Summaries

All 35

Developmental Gene Expression 1

Gene Ontology 3

Phenotypes 8
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:348964 Amici DR, et al., Tight regulation of a nuclear HAPSTR1-HUWE1 pathway essential for mammalian life. Life Sci Alliance. 2024 May;7(5)

TSS for Hapstr1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr137006	Chr16:8647860-8647885 (+)	-91 bp
Tssr137007	Chr16:8647901-8647922 (+)	-52 bp
Tssr137008	Chr16:8647957-8647968 (+)	-1 bp
Tssr137009	Chr16:8647979-8648006 (+)	29 bp
Tssr137010	Chr16:8648960-8648974 (+)	1,003 bp
Tssr137011	Chr16:8653828-8653834 (+)	5,867 bp
Tssr137012	Chr16:8655626-8655630 (+)	7,664 bp
Tssr137013	Chr16:8657390-8657393 (+)	9,428 bp
Tssr137014	Chr16:8668677-8668681 (+)	20,715 bp
Tssr137015	Chr16:8674857-8674864 (+)	26,897 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24