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Chac1 Gene Detail
Summary
  • Symbol
    Chac1
  • Name
    ChaC, cation transport regulator 1
  • Synonyms
    1810008K03Rik, Botch
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916315
    NCBI Gene: 69065
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:119181723-119184807 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 59.97 cM, cytoband E5
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    158 from dbSNP Build 142
  • Strain Annotations
    20
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916315
 protein coding gene Chr2:119181710-119184862 (+)
129S1/SvImJ ENSMUSG00200044105
 protein coding gene Chr2:116120990-116124139 (+)
A/J ENSMUSG00195022179
 protein coding gene Chr2:116169029-116172165 (+)
AKR/J ENSMUSG00220036036
 protein coding gene Chr2:116049026-116052174 (+)
AKR/J ENSMUSG00220036322
 protein coding gene Chr2:116086357-116089508 (+)
BALB/cJ ENSMUSG00180036602
 protein coding gene Chr2:115974138-115977274 (+)
C3H/HeJ ENSMUSG00175024190
 protein coding gene Chr2:116436371-116439520 (+)
C57BL/6NJ ENSMUSG00215012438
 protein coding gene Chr2:116098767-116101919 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024143
 protein coding gene Chr2:112184773-112187858 (+)
CAST/EiJ ENSTCUG00005015383
 protein coding gene Chr2:115373056-115376208 (+)
CBA/J ENSMUSG00210006775
 protein coding gene Chr2:116277333-116280480 (+)
DBA/2J ENSMUSG00185043116
 protein coding gene Chr2:115970836-115973972 (+)
FVB/NJ ENSMUSG00205032977
 protein coding gene Chr2:115187161-115190312 (+)
JF1/MsJ ENSUMUG00000020356
 protein coding gene Chr2:115840219-115843371 (+)
LP/J ENSMUSG00230015536
 protein coding gene Chr2:117780530-117783786 (+)
NOD/ShiLtJ ENSMUSG00190044980
 protein coding gene Chr2:116205599-116208748 (+)
NZO/HlLtJ ENSMUSG00225003401
 protein coding gene Chr2:125683852-125687108 (+)
PWK/PhJ ENSLUMG00010046035
 protein coding gene Chr2:115745436-115748590 (+)
SPRET/EiJ ENSMSPG00010036070
 protein coding gene Chr2:118148237-118151375 (+)
WSB/EiJ ENSIUOG00005024070
 protein coding gene Chr2:115936971-115940128 (+)



Homology
more
  • Human Ortholog
    CHAC1, ChaC glutathione specific gamma-glutamylcyclotransferase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CHAC1, ChaC glutathione specific gamma-glutamylcyclotransferase 1
  • Links
    NCBI Gene ID: 79094
    UniProt: Q9BUX1

  • Chr Location
    15q15.1; chr15:40952962-40956512 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    660
  • Tissues
    40
  • cDNA Data
    18
  • Literature Summary
    16
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 69065 NCBI Gene Model | MGI Sequence Detail 3085 C57BL/6J ±  kb
transcript NM_026929 RefSeq | MGI Sequence Detail 1583 C57BL/6  
polypeptide Q8R3J5 UniProt | EBI | MGI Sequence Detail 223 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000005398 glutathione-specific gamma-glutamylcyclotransferase 1
    (term hierarchy)
  • EC
    4.3.2.7
  • InterPro Domains
    IPR013024 Gamma-glutamyl cyclotransferase-like
    IPR036568 Gamma-glutamyl cyclotransferase-like superfamily
    IPR006840 Glutathione-specific gamma-glutamylcyclotransferase
Molecular
Reagents
less
  • All nucleic 24
    cDNA 18
    Primer pair 5
    Other 1
    Antibodies 2

    Microarray probesets 3
References
more
  • Summaries
    All 62
    Developmental Gene Expression 16
    Gene Ontology 12
    Phenotypes 11
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:391329 Duan CH, et al., Loss of Echs1 in neural stem and progenitor cells impairs neurogenesis via ER stress activation and lipid metabolic reprogramming. Nat Commun. 2026 Jul 1;17(1)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory