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Tcim Gene Detail
Summary
  • Symbol
    Tcim
  • Name
    transcriptional and immune response regulator
  • Synonyms
    1110065B09Rik, 1810011O10Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916318
    NCBI Gene: 69068
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:24927188-24928962 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 12.47 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    121 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916318
 protein coding gene Chr8:24927188-24929000 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033469
 protein coding gene Chr8:22423468-22425272 (-)
A/J MGP_AJ_G0033449
 protein coding gene Chr8:21647443-21649247 (-)
AKR/J MGP_AKRJ_G0033374
 protein coding gene Chr8:22357061-22358865 (-)
BALB/cJ MGP_BALBcJ_G0033445
 protein coding gene Chr8:21773559-21775363 (-)
C3H/HeJ MGP_C3HHeJ_G0033159
 protein coding gene Chr8:22547250-22549054 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033961
 protein coding gene Chr8:23314006-23315810 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030911
 protein coding gene Chr8:18957017-18958838 (-)
CAST/EiJ MGP_CASTEiJ_G0032485
 protein coding gene Chr8:21972055-21973862 (-)
CBA/J MGP_CBAJ_G0033134
 protein coding gene Chr8:24243617-24245421 (-)
DBA/2J MGP_DBA2J_G0033289
 protein coding gene Chr8:21616747-21618551 (-)
FVB/NJ MGP_FVBNJ_G0033233
 protein coding gene Chr8:21399807-21401611 (-)
LP/J MGP_LPJ_G0033378
 protein coding gene Chr8:22416503-22418307 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033276
 protein coding gene Chr8:23775510-23777314 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033980
 protein coding gene Chr8:22282398-22284202 (-)
PWK/PhJ MGP_PWKPhJ_G0032196
 protein coding gene Chr8:21219104-21220907 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032030
 protein coding gene Chr8:21654123-21655921 (-)
WSB/EiJ MGP_WSBEiJ_G0032601
 protein coding gene Chr8:22498498-22500302 (-)



Homology
more
  • Human Ortholog
    TCIM, transcriptional and immune response regulator
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TCIM, transcriptional and immune response regulator
  • Synonyms
    C8orf4, TC-1, TC1
  • Links
    NCBI Gene ID: 56892
    neXtProt AC: NX_Q9NR00
    UniProt: Q9NR00

  • Chr Location
    8p11.21; chr8:40153482-40155310 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 1 allele in 1 genetic background
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit myeloid and lymphoid hyperplasia, an increased number of small-sized red blood cells, increased hematopoietic stem cell number, and enhanced hematopoietic activity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    38
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    722
  • Tissues
    5
  • cDNA Data
    7
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 69068 NCBI Gene Model | MGI Sequence Detail 1775 C57BL/6J ±  kb
transcript NM_026931 RefSeq | MGI Sequence Detail 1775 C57BL/6  
polypeptide Q9D915 UniProt | EBI | MGI Sequence Detail 106 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000060105 transcriptional and immune response regulator
    (term hierarchy)
  • InterPro Domains
    IPR020282 Arginine vasopressin-induced protein 1/transcriptional and immune response regulator
    IPR039580 Transcriptional and immune response regulator
Molecular
Reagents
less
  • All nucleic 8
    cDNA 8

    Microarray probesets 4
Other
Accession IDs
less
MGI:1915083, MGI:2142767, MGI:2142785, MGI:5908149
References
more
  • Summaries
    All 32
    Developmental Gene Expression 3
    Gene Ontology 6
    Phenotypes 3
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:330740 Narayanan R, et al., Chromatin Remodeling BAF155 Subunit Regulates the Genesis of Basal Progenitors in Developing Cortex. iScience. 2018 Jun 29;4:109-126
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory