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Adamts9 Gene Detail
Summary
  • Symbol
    Adamts9
  • Name
    ADAM metallopeptidase with thrombospondin type 1 motif 9
  • Synonyms
    1810011L16Rik, 8430403M15Rik, E030027K14Rik, Gsfund3, Mhdaund3, Mhdaund4, UND3, UND4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916320
    NCBI Gene: 101401
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:92749680-92920473 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 41.41 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5034 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916320
 protein coding gene Chr6:92749680-92921431 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031060
 protein coding gene Chr6:94438518-94621108 (-)
A/J MGP_AJ_G0031029
 protein coding gene Chr6:90847460-91022356 (-)
AKR/J MGP_AKRJ_G0030960
 protein coding gene Chr6:93358508-93532922 (-)
BALB/cJ MGP_BALBcJ_G0031040
 protein coding gene Chr6:90800883-90973521 (-)
C3H/HeJ MGP_C3HHeJ_G0030666
 protein coding gene Chr6:90906100-91081659 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031499
 protein coding gene Chr6:96860025-97039848 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028666
 protein coding gene Chr6:88817318-88993597 (-)
CAST/EiJ MGP_CASTEiJ_G0030147
 protein coding gene Chr6:93494927-93677451 (-)
CBA/J MGP_CBAJ_G0030726
 protein coding gene Chr6:100476948-100662302 (-)
DBA/2J MGP_DBA2J_G0030879
 protein coding gene Chr6:90012586-90185002 (-)
FVB/NJ MGP_FVBNJ_G0030833
 protein coding gene Chr6:89234905-89405299 (-)
LP/J MGP_LPJ_G0030959
 protein coding gene Chr6:94397983-94572238 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030867
 protein coding gene Chr6:104489561-104674895 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031526
 protein coding gene Chr6:93215286-93391582 (-)
PWK/PhJ MGP_PWKPhJ_G0029863
 protein coding gene Chr6:88990221-89163581 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029692
 protein coding gene Chr6:92122437-92311767 (-)
WSB/EiJ MGP_WSBEiJ_G0030231
 protein coding gene Chr6:93682397-93860971 (-)



Homology
more
  • Human Ortholog
    ADAMTS9, ADAM metallopeptidase with thrombospondin type 1 motif 9
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ADAMTS9, ADAM metallopeptidase with thrombospondin type 1 motif 9
  • Links
    NCBI Gene ID: 56999
    neXtProt AC: NX_Q9P2N4
    UniProt: Q9P2N4

  • Chr Location
    3p14.1; chr3:64515654-64688000 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 8 alleles in 16 genetic backgrounds
    13 phenotypes from multigenic genotypes
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display embryonic lethality before somite formation. Mice heterozygous for a knock-out or ENU-induced allele exhibit a ring of epidermal hypopigmentation in the tail.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    919
  • Tissues
    156
  • cDNA Data
    14
  • Literature Summary
    26
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030022 Ensembl Gene Model | MGI Sequence Detail 170794 C57BL/6J ±  kb
    transcript ENSMUST00000113438 Ensembl | MGI Sequence Detail 8016 Not Applicable  
    polypeptide ENSMUSP00000109065 Ensembl | MGI Sequence Detail 1931 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • InterPro Domains
      IPR013273 ADAMTS/ADAMTS-like
      IPR010294 ADAMTS/ADAMTS-like, Spacer 1
      IPR050439 ADAMTS and ADAMTS-like
      IPR041645 ADAMTS, cysteine-rich domain 2
      IPR024079 Metallopeptidase, catalytic domain superfamily
      IPR001590 Peptidase M12B, ADAM/reprolysin
      IPR012314 Peptidase M12B, GON-ADAMTSs
      IPR002870 Peptidase M12B, propeptide
      IPR000884 Thrombospondin type-1 (TSP1) repeat
      IPR036383 Thrombospondin type-1 (TSP1) repeat superfamily
    Molecular
    Reagents
    less
    • All nucleic 23
      cDNA 16
      Primer pair 5
      Other 2

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:2141719, MGI:2442011, MGI:3530326, MGI:5629510
    References
    more
    • Summaries
      All 74
      Developmental Gene Expression 26
      Gene Ontology 10
      Phenotypes 31
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory