Triap1 Gene Detail

Summary

• Symbol
  Triap1
• Name
  TP53 regulated inhibitor of apoptosis 1
• Synonyms
  1810015M01Rik

• Feature Type
  protein coding gene
• IDs
  MGI:1916326
  NCBI Gene: 69076
• Alliance
  gene page
• Transcription Start Sites
  3 TSS

Location &
Maps

• Sequence Map
  Chr5:115479290-115481612 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 5, 56.06 cM
• Mapping Data
  2 experiments

Strain
Comparison

• SNPs within 2kb
  143 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1916326	protein coding gene	Chr5:115479284-115481628 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029967	protein coding gene	Chr5:118192180-118194522 (+)
A/J	MGP_AJ_G0029932	protein coding gene	Chr5:113506731-113509069 (+)
AKR/J	MGP_AKRJ_G0029870	protein coding gene	Chr5:117147752-117150457 (+)
BALB/cJ	MGP_BALBcJ_G0029943	protein coding gene	Chr5:114902814-114905150 (+)
C3H/HeJ	MGP_C3HHeJ_G0029662	protein coding gene	Chr5:117646894-117649233 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030397	protein coding gene	Chr5:122756203-122758547 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027624	protein coding gene	Chr5:108282046-108284792 (+)
CAST/EiJ	MGP_CASTEiJ_G0029071	protein coding gene	Chr5:116570298-116572629 (+)
CBA/J	MGP_CBAJ_G0029630	protein coding gene	Chr5:127472238-127474577 (+)
DBA/2J	MGP_DBA2J_G0029780	protein coding gene	Chr5:113580081-113582445 (+)
FVB/NJ	MGP_FVBNJ_G0029736	protein coding gene	Chr5:112398300-112400639 (+)
LP/J	MGP_LPJ_G0029868	protein coding gene	Chr5:118766488-118768824 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029767	protein coding gene	Chr5:131787566-131789902 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030438	protein coding gene	Chr5:116607267-116609609 (+)
PWK/PhJ	MGP_PWKPhJ_G0028784	protein coding gene	Chr5:112242323-112244653 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028622	protein coding gene	Chr5:114166960-114169481 (+)
WSB/EiJ	MGP_WSBEiJ_G0029146	protein coding gene	Chr5:117205416-117207757 (+)

Homology

• Human Ortholog
  TRIAP1, TP53 regulated inhibitor of apoptosis 1

• Vertebrate Orthologs
  3

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  TRIAP1, TP53 regulated inhibitor of apoptosis 1
  
• Synonyms
  HSPC132, MDM35, P53CSV, WF-1
• Links
  HGNC:26937

  NCBI Gene ID: 51499

  neXtProt AC: NX_O43715

  UniProt: O43715

  
  
• Chr Location
  12q24.31; chr12:120443964-120446384 (-)  GRCh38

---

• MGI Vertebrate Homology
  Triap1 stringent orthology
  1 human;1 mouse;1 rat;1 zebrafish
  
• HCOP
  vertebrate homology predictions: TRIAP1
• Gene Tree
  Triap1
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  12 phenotype references
  

• All Mutations and Alleles
  11
• Chemically induced (other)
  1
• Endonuclease-mediated
  1
• Gene trapped
  6
• Radiation induced
  1
• Targeted
  2
• Genomic Mutations
  2 involving Triap1
• Find Mice (IMSR)
  6 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  38
• GO References
  7

Expression

• Assay Results
  708
• Tissues
  1
• cDNA Data
  72
• Literature Summary
  1

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase triap1
  ZFIN triap1

Sequences &
Gene Models

• All Sequences
  33
• RefSeq
  2
• UniProt
  1
• CCDS
  CCDS39228.1

• Ensembl
  ENSMUSG00000029535 (Evidence)
• NCBI Gene
  69076

Representative Sequences			Length	Strain/Species
genomic	69076	NCBI Gene Model | MGI Sequence Detail	2323	C57BL/6J
transcript	NM_026933	RefSeq | MGI Sequence Detail	1066	C57BL/6
polypeptide	Q9D8Z2	UniProt | EBI | MGI Sequence Detail	76	Not Applicable

Protein
Information

• UniProt
  1 Sequence
• Protein Ontology
  PR:000016637 TP53-regulated inhibitor of apoptosis 1
  (term hierarchy)
• InterPro Domains
  IPR007918 Mitochondrial distribution/morphology family 35/apoptosis

Molecular
Reagents

• All nucleic 73

  cDNA 72

  Primer pair 1

  
  

  Microarray probesets 3

Other
Accession IDs

MGI:2141053, MGI:2141091

References

• Summaries
  All 39

  Developmental Gene Expression 1

  Gene Ontology 7

  Phenotypes 12
• Earliest
  J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
• Latest
  J:344404 Ma J, et al., CHCHD4-TRIAP1 regulation of innate immune signaling mediates skeletal muscle adaptation to exercise. Cell Rep. 2023 Dec 28;43(1):113626

TSS for Triap1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr48222	Chr5:115479284-115479329 (+)	17 bp
Tssr48223	Chr5:115479347-115479356 (+)	62 bp
Tssr48224	Chr5:115479374-115479383 (+)	89 bp