Psmd11 MGI Mouse Gene Detail - MGI:1916327 - proteasome (prosome, macropain) 26S subunit, non-ATPase, 11

Symbol

Psmd11
Name

proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
Synonyms

1700089D09Rik, 1810019E17Rik, 2610024G20Rik, 2810055C24Rik, C78232, P44.5, S9

Feature Type

protein coding gene
IDs

MGI:1916327
NCBI Gene: 69077
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr11:80319441-80364074 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 47.89 cM
Mapping Data

2 experiments

SNPs within 2kb

825 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1916327	protein coding gene	Chr11:80319441-80364074 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018813	protein coding gene	Chr11:81590625-81639032 (+)
A/J	MGP_AJ_G0018780	protein coding gene	Chr11:78458645-78503271 (+)
AKR/J	MGP_AKRJ_G0018750	protein coding gene	Chr11:80815482-80860388 (+)
BALB/cJ	MGP_BALBcJ_G0018753	protein coding gene	Chr11:78854387-78902044 (+)
C3H/HeJ	MGP_C3HHeJ_G0018567	protein coding gene	Chr11:80862296-80924451 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019205	protein coding gene	Chr11:84080929-84131769 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016839	protein coding gene	Chr11:75387546-75432834 (+)
CAST/EiJ	MGP_CASTEiJ_G0018122	protein coding gene	Chr11:81352765-81401111 (+)
CBA/J	MGP_CBAJ_G0018538	protein coding gene	Chr11:87767114-87820786 (+)
DBA/2J	MGP_DBA2J_G0018646	protein coding gene	Chr11:78017111-78063131 (+)
FVB/NJ	MGP_FVBNJ_G0018635	protein coding gene	Chr11:77587078-77632125 (+)
LP/J	MGP_LPJ_G0018716	protein coding gene	Chr11:82115321-82164275 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018662	protein coding gene	Chr11:88029032-88077783 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019245	protein coding gene	Chr11:81069552-81126684 (+)
PWK/PhJ	MGP_PWKPhJ_G0017892	protein coding gene	Chr11:78829375-78877994 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017683	protein coding gene	Chr11:80665786-80716578 (+)
WSB/EiJ	MGP_WSBEiJ_G0018174	protein coding gene	Chr11:80905711-80955061 (+)

Human Ortholog

PSMD11, proteasome 26S subunit, non-ATPase 11

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PSMD11, proteasome 26S subunit, non-ATPase 11
Synonyms

p44.5, Rpn6, S9
Links

HGNC:9556

NCBI Gene ID: 5717

neXtProt AC: NX_O00231

UniProt: O00231
Chr Location

17q11.2; chr17:32444379-32483319 (+) GRCh38

MGI Vertebrate Homology

Psmd11 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: PSMD11
Gene Tree

Psmd11

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Phenotype Summary

4 phenotypes from 2 alleles in 2 genetic backgrounds
22 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

35
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

27
Targeted

5
Genomic Mutations

2 involving Psmd11
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

41 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice are embryonic lethal before E7.5. Heterozygous mice are growth retarded.

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All GO Annotations

15
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

734
Tissues

18
cDNA Data

170
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase psmd11

ZFIN psmd11a, psmd11b

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All Sequences

105
RefSeq

4
UniProt

20
CCDS

CCDS25133.1

Ensembl

ENSMUSG00000017428 (Evidence)
NCBI Gene

69077

			Length	Strain/Species	Flank
genomic	69077	NCBI Gene Model \| MGI Sequence Detail	44634	C57BL/6J	± kb
transcript	NM_178616	RefSeq \| MGI Sequence Detail	1743	C57BL/6
polypeptide	Q8BG32	UniProt \| EBI \| MGI Sequence Detail	422	Not Applicable

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UniProt

20 Sequences
Protein Ontology

PR:000002177 26S proteasome non-ATPase regulatory subunit 11

(term hierarchy)
InterPro Domains

IPR050871 26S Proteasome and COP9 Signalosome Components

IPR040773 26S proteasome regulatory subunit Rpn6, N-terminal

IPR040780 6S proteasome subunit Rpn6, C-terminal helix domain

IPR000717 Proteasome component (PCI) domain

IPR011990 Tetratricopeptide-like helical domain superfamily

IPR036390 Winged helix DNA-binding domain superfamily
GlyGen

Q8BG32 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 176

cDNA 174

Primer pair 2

Microarray probesets 7

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MGI:1919948, MGI:1920769, MGI:1922061, MGI:2144638

Summaries

All 54

Developmental Gene Expression 4

Gene Ontology 7

Phenotypes 22
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Psmd11:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr103529	Chr11:80319424-80319482 (+)	12 bp
Tssr103530	Chr11:80320558-80320569 (+)	1,123 bp
Tssr103531	Chr11:80322292-80322302 (+)	2,856 bp
Tssr103532	Chr11:80333524-80333529 (+)	14,086 bp
Tssr103533	Chr11:80335727-80335731 (+)	16,288 bp
Tssr103534	Chr11:80347781-80347807 (+)	28,353 bp
Tssr103537	Chr11:80361644-80361655 (+)	42,209 bp
Tssr103538	Chr11:80363206-80363243 (+)	43,784 bp
Tssr103539	Chr11:80363437-80363447 (+)	44,001 bp
Tssr103540	Chr11:80363485-80363502 (+)	44,053 bp
Tssr103541	Chr11:80363509-80363512 (+)	44,070 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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