Ptgr2 MGI Mouse Gene Detail - MGI:1916372 - prostaglandin reductase 2

Symbol

Ptgr2
Name

prostaglandin reductase 2
Synonyms

1810016I24Rik, 9630002F03Rik, B830026H24Rik, PGR-2, Zadh1

Feature Type

protein coding gene
IDs

MGI:1916372
NCBI Gene: 77219
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr12:84332011-84362606 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 39.14 cM, cytoband D3
Mapping Data

3 experiments

SNPs within 2kb

838 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1916372	protein coding gene	Chr12:84332006-84362606 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019931	protein coding gene	Chr12:84980649-85016967 (+)
A/J	MGP_AJ_G0019888	protein coding gene	Chr12:81763612-81794379 (+)
AKR/J	MGP_AKRJ_G0019864	protein coding gene	Chr12:83977314-84013670 (+)
BALB/cJ	MGP_BALBcJ_G0019868	protein coding gene	Chr12:82094819-82125672 (+)
C3H/HeJ	MGP_C3HHeJ_G0019674	protein coding gene	Chr12:84449069-84479093 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020319	protein coding gene	Chr12:87419424-87453953 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017937	protein coding gene	Chr12:78672931-78702786 (+)
CAST/EiJ	MGP_CASTEiJ_G0019223	protein coding gene	Chr12:79393988-79430624 (+)
CBA/J	MGP_CBAJ_G0019645	protein coding gene	Chr12:90797391-90834162 (+)
DBA/2J	MGP_DBA2J_G0019760	protein coding gene	Chr12:81298066-81328348 (+)
FVB/NJ	MGP_FVBNJ_G0019746	protein coding gene	Chr12:80250283-80280352 (+)
LP/J	MGP_LPJ_G0019832	protein coding gene	Chr12:84862900-84894759 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019785	protein coding gene	Chr12:93716676-93748585 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020353	protein coding gene	Chr12:83577046-83609370 (+)
PWK/PhJ	MGP_PWKPhJ_G0018987	protein coding gene	Chr12:75783440-75815034 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018782	protein coding gene	Chr12:78063476-78095793 (+)
WSB/EiJ	MGP_WSBEiJ_G0019275	protein coding gene	Chr12:84290734-84320409 (+)

Human Ortholog

PTGR2, prostaglandin reductase 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PTGR2, prostaglandin reductase 2
Synonyms

HEL-S-298, PGR2, ZADH1
Links

HGNC:20149

NCBI Gene ID: 145482

neXtProt AC: NX_Q8N8N7

UniProt: Q8N8N7
Chr Location

14q24.3; chr14:73851831-73885726 (+) GRCh38

MGI Vertebrate Homology

Ptgr2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PTGR2
Gene Tree

Ptgr2

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

5
Targeted

1
Genomic Mutations

1 involving Ptgr2
Incidental Mutations

APF
Find Mice (IMSR)

21 strains or lines available

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All GO Annotations

8
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

16

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ptgr2

ZFIN ptgr2

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All Sequences

71
RefSeq

10
UniProt

3
CCDS

CCDS36490.1

Ensembl

ENSMUSG00000072946 (Evidence)
NCBI Gene

77219

			Length	Strain/Species	Flank
genomic	77219	NCBI Gene Model \| MGI Sequence Detail	30596	C57BL/6J	± kb
transcript	NM_001252626	RefSeq \| MGI Sequence Detail	3250	C57BL/6
polypeptide	Q8VDQ1	UniProt \| EBI \| MGI Sequence Detail	351	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000013426 prostaglandin reductase 2

(term hierarchy)
PDB

1VJ1, 2ZB3
EC

1.3.1.48
InterPro Domains

IPR013149 Alcohol dehydrogenase-like, C-terminal

IPR011032 GroES-like superfamily

IPR045010 Medium-chain dehydrogenase/reductase

IPR036291 NAD(P)-binding domain superfamily

IPR041694 Oxidoreductase, N-terminal domain

IPR037399 Prostaglandin reductase 2
GlyGen

Q8VDQ1 4 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (3 sites)

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All nucleic 16

cDNA 16

Microarray probesets 8

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MGI:1924469, MGI:1926101, MGI:2144889

Summaries

All 36

Gene Ontology 4

Phenotypes 9
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:185071 Yaguchi H, et al., TRIM67 protein negatively regulates Ras activity through degradation of 80K-H and induces neuritogenesis. J Biol Chem. 2012 Apr 6;287(15):12050-9

TSS for Ptgr2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr114333	Chr12:84332110-84332188 (+)	138 bp
Tssr114334	Chr12:84342993-84342996 (+)	10,984 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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