Eci3 MGI Mouse Gene Detail - MGI:1916373 - enoyl-Coenzyme A delta isomerase 3

Symbol

Eci3
Name

enoyl-Coenzyme A delta isomerase 3
Synonyms

1810022C23Rik

Feature Type

protein coding gene
IDs

MGI:1916373
NCBI Gene: 69123
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr13:35130597-35147793 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 14.23 cM, cytoband A4
Mapping Data

2 experiments

SNPs within 2kb

635 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1916373	protein coding gene	Chr13:35130595-35147971 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0020456	protein coding gene	Chr13:33089668-33109492 (-)
A/J	MGP_AJ_G0020410	protein coding gene	Chr13:32088608-32118441 (-)
AKR/J	MGP_AKRJ_G0020388	protein coding gene	Chr13:32863792-32883801 (-)
BALB/cJ	MGP_BALBcJ_G0020406	protein coding gene	Chr13:32167914-32185369 (-)
C3H/HeJ	MGP_C3HHeJ_G0020205	protein coding gene	Chr13:32791244-32810830 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0020840	protein coding gene	Chr13:34273484-34304764 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018426	protein coding gene	Chr13:30393181-30410111 (-)
CAST/EiJ	MGP_CASTEiJ_G0019720	protein coding gene	Chr13:32472165-32495565 (-)
CBA/J	MGP_CBAJ_G0020166	protein coding gene	Chr13:35660973-35715497 (-)
DBA/2J	MGP_DBA2J_G0020288	protein coding gene	Chr13:31629576-31657848 (-)
FVB/NJ	MGP_FVBNJ_G0020267	protein coding gene	Chr13:31199474-31218997 (-)
LP/J	MGP_LPJ_G0020363	protein coding gene	Chr13:33333813-33362088 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020297	protein coding gene	Chr13:35837310-35871660 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020882	protein coding gene	Chr13:32511042-32533903 (-)
PWK/PhJ	MGP_PWKPhJ_G0019475	protein coding gene	Chr13:31764879-31784039 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0019302	protein coding gene	Chr13:31147996-31166907 (-)
WSB/EiJ	MGP_WSBEiJ_G0019782	protein coding gene	Chr13:32883934-32903816 (-)

Human Ortholog

ECI2, enoyl-CoA delta isomerase 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ECI2, enoyl-CoA delta isomerase 2
Synonyms

ACBD2, dJ1013A10.3, DRS-1, DRS1, HCA88, PECI
Links

HGNC:14601

NCBI Gene ID: 10455

neXtProt AC: NX_O75521

UniProt: O75521
Chr Location

6p25.2; chr6:4115693-4135597 (-) GRCh38

MGI Vertebrate Homology

Eci3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ECI2
Gene Tree

Eci3

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Gene trapped

1
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Eci3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

20 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

17
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

27

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

38
RefSeq

8
UniProt

2
CCDS

CCDS26449.1

Ensembl

ENSMUSG00000021416 (Evidence)
NCBI Gene

69123

			Length	Strain/Species	Flank
genomic	ENSMUSG00000021416	Ensembl Gene Model \| MGI Sequence Detail	17197	C57BL/6J	± kb
transcript	ENSMUST00000021853	Ensembl \| MGI Sequence Detail	1347	Not Applicable
polypeptide	ENSMUSP00000021853	Ensembl \| MGI Sequence Detail	317	Not Applicable

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UniProt

2 Sequences
EC

5.3.3.8
InterPro Domains

IPR000582 Acyl-CoA-binding protein, ACBP

IPR035984 Acyl-CoA binding protein superfamily

IPR029045 ClpP/crotonase-like domain superfamily

IPR014748 Enoyl-CoA hydratase, C-terminal

IPR001753 Enoyl-CoA hydratase/isomerase

IPR051053 Enoyl-CoA hydratase/isomerase and chromodomain-containing protein

IPR014352 FERM/acyl-CoA-binding protein superfamily

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All nucleic 27

cDNA 27

Microarray probesets 2

Summaries

All 39

Gene Ontology 5

Phenotypes 17
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Eci3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr122074	Chr13:35147808-35147819 (-)	-21 bp
Tssr122073	Chr13:35147774-35147799 (-)	6 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24