Mcemp1 Gene Detail

Summary

• Symbol
  Mcemp1
• Name
  mast cell expressed membrane protein 1
• Synonyms
  1810033B17Rik

• Feature Type
  protein coding gene
• IDs
  MGI:1916439
  NCBI Gene: 69189
• Alliance
  gene page
• Transcription Start Sites
  4 TSS

Location &
Maps

• Sequence Map
  Chr8:3715754-3718916 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 8, 1.92 cM, cytoband A1
• Mapping Data
  3 experiments

Strain
Comparison

• SNPs within 2kb
  175 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1916439	protein coding gene	Chr8:3715754-3719259 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033314	protein coding gene	Chr8:611431-614097 (+)
A/J	MGP_AJ_G0033297	protein coding gene	Chr8:582038-584667 (+)
AKR/J	MGP_AKRJ_G0033228	protein coding gene	Chr8:611966-614595 (+)
BALB/cJ	MGP_BALBcJ_G0033297	protein coding gene	Chr8:607800-610438 (+)
C3H/HeJ	MGP_C3HHeJ_G0033011	protein coding gene	Chr8:625118-627747 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0033807	protein coding gene	Chr8:658471-661614 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030780	protein coding gene	Chr8:533907-536573 (+)
CAST/EiJ	MGP_CASTEiJ_G0032334	protein coding gene	Chr8:617087-620363 (+)
CBA/J	MGP_CBAJ_G0032984	protein coding gene	Chr8:673498-676127 (+)
DBA/2J	MGP_DBA2J_G0033138	protein coding gene	Chr8:552797-555426 (+)
FVB/NJ	MGP_FVBNJ_G0033085	protein coding gene	Chr8:601676-604305 (+)
LP/J	MGP_LPJ_G0033230	protein coding gene	Chr8:595618-598247 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033120	protein coding gene	Chr8:651516-654145 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033825	protein coding gene	Chr8:602786-608054 (+)
PWK/PhJ	MGP_PWKPhJ_G0032044	protein coding gene	Chr8:581395-584053 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031888	protein coding gene	Chr8:594401-597147 (+)
WSB/EiJ	MGP_WSBEiJ_G0032447	protein coding gene	Chr8:599176-603869 (+)

Homology

• Human Ortholog
  MCEMP1, mast cell expressed membrane protein 1

• Vertebrate Orthologs
  2

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  MCEMP1, mast cell expressed membrane protein 1
  
• Synonyms
  C19orf59
• Links
  HGNC:27291

  NCBI Gene ID: 199675

  neXtProt AC: NX_Q8IX19

  UniProt: Q8IX19

  
  
• Chr Location
  19p13.2; chr19:7677088-7679829 (+)  GRCh38

---

• MGI Vertebrate Homology
  Mcemp1 stringent orthology
  1 human;1 mouse;1 rat
  
• HCOP
  vertebrate homology predictions: MCEMP1
• Gene Tree
  Mcemp1
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  2 phenotypes from 1 allele in 1 genetic background
  4 phenotype references
  

• All Mutations and Alleles
  4
• Endonuclease-mediated
  2
• Targeted
  2
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  12 strains or lines available

Mice homozygous for a null allele exhibit reduced mast cell proliferation and reduced airway inflammation in a chronic asthma model.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  2
• GO References
  2

Expression

• Assay Results
  706
• cDNA Data
  8

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  30
• RefSeq
  2
• UniProt
  1
• CCDS
  CCDS22069.1

• Ensembl
  ENSMUSG00000013974 (Evidence)
• NCBI Gene
  69189

Representative Sequences			Length	Strain/Species
genomic	69189	NCBI Gene Model | MGI Sequence Detail	3163	C57BL/6J
transcript	NM_026985	RefSeq | MGI Sequence Detail	1151	ZRU/MplStud
polypeptide	Q9D8U6	UniProt | EBI | MGI Sequence Detail	183	Not Applicable

Protein
Information

• UniProt
  1 Sequence
• Protein Ontology
  PR:000010236 mast cell-expressed membrane protein 1
  (term hierarchy)
• InterPro Domains
  IPR038818 Mast cell-expressed membrane protein 1
• GlyGen
  Q9D8U6 2 sites, 1 O-linked glycan (1 site)

Molecular
Reagents

• All nucleic 9

  Genomic 1

  cDNA 8

  
  

  Microarray probesets 2

References

• Summaries
  All 26

  Gene Ontology 2

  Phenotypes 4
• Earliest
  J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
• Latest
  J:335318 Choi YJ, et al., Lung-specific MCEMP1 functions as an adaptor for KIT to promote SCF-mediated mast cell proliferation. Nat Commun. 2023 Apr 11;14(1):2045

TSS for Mcemp1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr76084	Chr8:3714746-3714783 (+)	-989 bp
Tssr76085	Chr8:3715747-3715763 (+)	1 bp
Tssr76086	Chr8:3715773-3715784 (+)	25 bp
Tssr76087	Chr8:3715958-3715968 (+)	209 bp