Svbp MGI Mouse Gene Detail - MGI:1916466 - small vasohibin binding protein

Symbol

Svbp
Name

small vasohibin binding protein
Synonyms

2410005K17Rik, Ccdc23, Svbp

Feature Type

protein coding gene
IDs

MGI:1916466
NCBI Gene: 69216
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr4:119052507-119058495 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 55.34 cM
Mapping Data

2 experiments

SNPs within 2kb

226 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1916466	protein coding gene	Chr4:119052503-119058495 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028690	protein coding gene	Chr4:120379230-120385421 (+)
A/J	MGP_AJ_G0028650	protein coding gene	Chr4:115648759-115654748 (+)
AKR/J	MGP_AKRJ_G0028603	protein coding gene	Chr4:118159160-118165152 (+)
BALB/cJ	MGP_BALBcJ_G0028673	protein coding gene	Chr4:116264715-116270490 (+)
C3H/HeJ	MGP_C3HHeJ_G0028388	protein coding gene	Chr4:119724901-119730676 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029114	protein coding gene	Chr4:124949371-124955363 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026391	protein coding gene	Chr4:109750289-109756074 (+)
CAST/EiJ	MGP_CASTEiJ_G0027819	protein coding gene	Chr4:117045888-117052456 (+)
CBA/J	MGP_CBAJ_G0028355	protein coding gene	Chr4:128329121-128334896 (+)
DBA/2J	MGP_DBA2J_G0028502	protein coding gene	Chr4:116239456-116245445 (+)
FVB/NJ	MGP_FVBNJ_G0028468	protein coding gene	Chr4:114753534-114759332 (+)
LP/J	MGP_LPJ_G0028602	protein coding gene	Chr4:120484470-120490670 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028496	protein coding gene	Chr4:133195731-133201509 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029151	protein coding gene	Chr4:119232420-119238601 (+)
PWK/PhJ	MGP_PWKPhJ_G0027542	protein coding gene	Chr4:113160951-113166952 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027368	protein coding gene	Chr4:115656123-115661895 (+)
WSB/EiJ	MGP_WSBEiJ_G0027899	protein coding gene	Chr4:119233135-119239118 (+)

Human Ortholog

SVBP, small vasohibin binding protein

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SVBP, small vasohibin binding protein
Synonyms

CCDC23, NEDAHM
Links

HGNC:29204

NCBI Gene ID: 374969

neXtProt AC: NX_Q8N300

UniProt: Q8N300
Chr Location

1p34.2; chr1:42807052-42817397 (-) GRCh38

MGI Vertebrate Homology

Svbp stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SVBP
Gene Tree

Svbp

less

Phenotype Summary

20 phenotypes from 1 allele in 1 genetic background
5 phenotypes from multigenic genotypes
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

2
Endonuclease-mediated

1
Gene trapped

3
Radiation induced

1
Targeted

2
Transgenic

1
Genomic Mutations

4 involving Svbp
Find Mice (IMSR)

6 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit reduced brain size, abnormal neuron physiology, hyperactivity, decreased social investigation, and exhibit reduced marble burying.

less

All GO Annotations

24
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

711
Tissues

5
cDNA Data

59
Literature Summary

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

less

All Sequences

44
RefSeq

4
UniProt

4
CCDS

CCDS18572.1, CCDS38858.1

Ensembl

ENSMUSG00000028643 (Evidence)
NCBI Gene

69216

			Length	Strain/Species	Flank
genomic	69216	NCBI Gene Model \| MGI Sequence Detail	5989	C57BL/6J	± kb
transcript	NM_001038998	RefSeq \| MGI Sequence Detail	822	C57BL/6
polypeptide	Q99LQ4	UniProt \| EBI \| MGI Sequence Detail	66	Not Applicable

less

UniProt

4 Sequences
Protein Ontology

PR:000031911 small vasohibin-binding protein

(term hierarchy)
InterPro Domains

IPR031378 Small vasohibin-binding protein

less

All nucleic 60

cDNA 59

Primer pair 1

Microarray probesets 2

less

MGI:2140387

Summaries

All 38

Developmental Gene Expression 2

Gene Ontology 9

Phenotypes 12
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:325393 Landskron L, et al., Posttranslational modification of microtubules by the MATCAP detyrosinase. Science. 2022 May 20;376(6595):eabn6020

TSS for Svbp:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr38718	Chr4:119052476-119052490 (+)	-24 bp
Tssr38719	Chr4:119052532-119052541 (+)	30 bp
Tssr38720	Chr4:119052550-119052592 (+)	64 bp
Tssr38721	Chr4:119052613-119052623 (+)	111 bp
Tssr38722	Chr4:119052641-119052652 (+)	140 bp
Tssr38723	Chr4:119052709-119052712 (+)	204 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24