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Rfc3 Gene Detail
Summary
  • Symbol
    Rfc3
  • Name
    replication factor C (activator 1) 3
  • Synonyms
    2810416I22Rik, 38kDa, 38kDa, Recc3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916513
    NCBI Gene: 69263
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:151566282-151574673 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 90.18 cM, cytoband G3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    280 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916513
 protein coding gene Chr5:151566221-151574707 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030418
 protein coding gene Chr5:157622308-157630776 (-)
A/J MGP_AJ_G0030391
 protein coding gene Chr5:150877603-150886089 (-)
AKR/J MGP_AKRJ_G0030318
 protein coding gene Chr5:155514603-155523086 (-)
BALB/cJ MGP_BALBcJ_G0030400
 protein coding gene Chr5:152134134-152142620 (-)
C3H/HeJ MGP_C3HHeJ_G0030114
 protein coding gene Chr5:156537364-156545850 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030855
 protein coding gene Chr5:163335997-163344483 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028067
 protein coding gene Chr5:145200182-145209913 (-)
CAST/EiJ MGP_CASTEiJ_G0029515
 protein coding gene Chr5:156204190-156214836 (-)
CBA/J MGP_CBAJ_G0030092
 protein coding gene Chr5:170227041-170235527 (-)
DBA/2J MGP_DBA2J_G0030236
 protein coding gene Chr5:150513241-150521727 (-)
FVB/NJ MGP_FVBNJ_G0030190
 protein coding gene Chr5:149758565-149767396 (-)
LP/J MGP_LPJ_G0030323
 protein coding gene Chr5:158241378-158249846 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030226
 protein coding gene Chr5:172292616-172301097 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030885
 protein coding gene Chr5:155493826-155502312 (-)
PWK/PhJ MGP_PWKPhJ_G0029230
 protein coding gene Chr5:149654073-149662766 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029066
 protein coding gene Chr5:152731701-152740168 (-)
WSB/EiJ MGP_WSBEiJ_G0029592
 protein coding gene Chr5:156308980-156317461 (-)



Homology
more
  • Human Ortholog
    RFC3, replication factor C subunit 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RFC3, replication factor C subunit 3
  • Synonyms
    RFC38
  • Links
    NCBI Gene ID: 5983
    neXtProt AC: NX_P40938
    UniProt: P40938

  • Chr Location
    13q13.2; chr13:33818069-33977377 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    756
  • Tissues
    13
  • cDNA Data
    69
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 69263 NCBI Gene Model | MGI Sequence Detail 8392 C57BL/6J ±  kb
transcript NM_001417694 RefSeq | MGI Sequence Detail 1465 C57BL/6  
polypeptide Q8R323 UniProt | EBI | MGI Sequence Detail 356 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000013907 replication factor C subunit 3
    (term hierarchy)
  • InterPro Domains
    IPR003593 AAA+ ATPase domain
    IPR008921 DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminal
    IPR050238 DNA Replication and Repair Clamp Loader Complex
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
  • GlyGen
    Q8R323 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 70
    cDNA 70

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-13827, MGI:2141068, MGI:97893
References
more
  • Summaries
    All 41
    Developmental Gene Expression 3
    Gene Ontology 8
    Phenotypes 4
  • Earliest
    J:40897 Bunz F, et al., cDNAs encoding the large subunit of human replication factor C. Proc Natl Acad Sci U S A. 1993 Dec 1;90(23):11014-8
  • Latest
    J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory