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Tmt1a Gene Detail
Summary
  • Symbol
    Tmt1a
  • Name
    thiol methyltransferase 1A1
  • Synonyms
    2210414H16Rik, 3300001H21Rik, Mettl7a, Mettl7a1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916523
    NCBI Gene: 70152
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:100202021-100226543 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 56.25 cM, cytoband F3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    703 from dbSNP Build 142
  • Strain Annotations
    16
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916523
 protein coding gene Chr15:100201969-100227882 (+)
129S1/SvImJ no annotation
A/J MGP_AJ_G0022308
 protein coding gene Chr15:98160588-98172147 (+)
AKR/J MGP_AKRJ_G0022284
 protein coding gene Chr15:101187474-101204924 (+)
BALB/cJ MGP_BALBcJ_G0022315
 protein coding gene Chr15:98334521-98350713 (+)
C3H/HeJ MGP_C3HHeJ_G0022082
 protein coding gene Chr15:101259521-101303256 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022759
 protein coding gene Chr15:106053334-106062080 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020286
 protein coding gene Chr15:94047034-94052464 (+)
CAST/EiJ MGP_CASTEiJ_G0021609
 protein coding gene Chr15:102136933-102149109 (+)
CBA/J MGP_CBAJ_G0022052
 protein coding gene Chr15:109766133-109783372 (+)
DBA/2J MGP_DBA2J_G0022178
 protein coding gene Chr15:97580121-97594027 (+)
FVB/NJ MGP_FVBNJ_G0022158
 protein coding gene Chr15:96573698-96582308 (+)
LP/J MGP_LPJ_G0022250
 protein coding gene Chr15:102380959-102398479 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022179
 protein coding gene Chr15:113517201-113527055 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022775
 protein coding gene Chr15:101285379-101294896 (+)
PWK/PhJ MGP_PWKPhJ_G0021348
 protein coding gene Chr15:97770017-97778796 (+)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0021660
 protein coding gene Chr15:101819537-101827958 (+)



Homology
more
  • Human Ortholog
    TMT1A, thiol methyltransferase 1A
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMT1A, thiol methyltransferase 1A
  • Synonyms
    AAM-B, AAMB, METTL7A
  • Links
    NCBI Gene ID: 25840
    neXtProt AC: NX_Q9H8H3
    UniProt: Q9H8H3

  • Chr Location
    12q13.12; chr12:50923472-50932510 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotype references
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    4
  • Gene trapped
    1
  • Radiation induced
    2
  • Targeted
    1
  • Genomic Mutations
    3 involving Tmt1a
  • Incidental Mutations
    Mutagenetix , APF
  • Find Mice (IMSR)
    13 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    6
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000054619 Ensembl Gene Model | MGI Sequence Detail 24523 C57BL/6J ±  kb
transcript ENSMUST00000067752 Ensembl | MGI Sequence Detail 1946 Not Applicable  
polypeptide ENSMUSP00000065271 Ensembl | MGI Sequence Detail 244 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    11 Sequences
  • InterPro Domains
    IPR013216 Methyltransferase type 11
    IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily
    IPR052356 Thiol S-methyltransferase
Molecular
Reagents
less
  • All nucleic 8
    cDNA 8

    Microarray probesets 7
Other
Accession IDs
less
MGI:1917402, MGI:7461484
References
more
  • Summaries
    All 48
    Diseases 1
    Gene Ontology 2
    Phenotypes 26
  • Earliest
    J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
  • Latest
    J:327245 Briata P, et al., LncRNA EPR-induced METTL7A1 modulates target gene translation. Nucleic Acids Res. 2022 Jul 22;50(13):7608-7622
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory