Sec62 MGI Mouse Gene Detail - MGI:1916526 - SEC62 homolog, preprotein translocation

Symbol

Sec62
Name

SEC62 homolog, preprotein translocation
Synonyms

3100002M17Rik, Dtrp1, HTP1, SEC62, Tloc1

Feature Type

protein coding gene
IDs

MGI:1916526
NCBI Gene: 69276
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr3:30847025-30875412 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 14.29 cM, cytoband A3
Mapping Data

3 experiments

SNPs within 2kb

701 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1916526	protein coding gene	Chr3:30847024-30875412 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027127	protein coding gene	Chr3:28295636-28326409 (+)
A/J	MGP_AJ_G0027087	protein coding gene	Chr3:27927478-27955834 (+)
AKR/J	MGP_AKRJ_G0027056	protein coding gene	Chr3:28357481-28385831 (+)
BALB/cJ	MGP_BALBcJ_G0027099	protein coding gene	Chr3:27618896-27647354 (+)
C3H/HeJ	MGP_C3HHeJ_G0026841	protein coding gene	Chr3:28377709-28406253 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027545	protein coding gene	Chr3:29804286-29832595 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024906	protein coding gene	Chr3:25841057-25869867 (+)
CAST/EiJ	MGP_CASTEiJ_G0026295	protein coding gene	Chr3:28296375-28324932 (+)
CBA/J	MGP_CBAJ_G0026819	protein coding gene	Chr3:30553471-30583066 (+)
DBA/2J	MGP_DBA2J_G0026953	protein coding gene	Chr3:27477569-27505815 (+)
FVB/NJ	MGP_FVBNJ_G0026921	protein coding gene	Chr3:26926498-26955780 (+)
LP/J	MGP_LPJ_G0027064	protein coding gene	Chr3:28994616-29024160 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026941	protein coding gene	Chr3:33137542-33169365 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027604	protein coding gene	Chr3:28095892-28124177 (+)
PWK/PhJ	MGP_PWKPhJ_G0026028	protein coding gene	Chr3:26996290-27025000 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025840	protein coding gene	Chr3:27628322-27656633 (+)
WSB/EiJ	MGP_WSBEiJ_G0026369	protein coding gene	Chr3:28196009-28225415 (+)

Human Ortholog

SEC62, SEC62 homolog, preprotein translocation factor

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SEC62, SEC62 homolog, preprotein translocation factor
Synonyms

Dtrp1, HTP1, TLOC1, TP-1
Links

HGNC:11846

NCBI Gene ID: 7095

neXtProt AC: NX_Q99442

UniProt: Q99442
Chr Location

3q26.2; chr3:169966635-169998373 (+) GRCh38

MGI Vertebrate Homology

Sec62 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SEC62
Gene Tree

Sec62

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References

1 with disease annotations

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

26
Endonuclease-mediated

2
Gene trapped

23
Radiation induced

1
Genomic Mutations

1 involving Sec62
Incidental Mutations

APF
Find Mice (IMSR)

28 strains or lines available

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All GO Annotations

8
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

15
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase sec62

ZFIN sec62

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All Sequences

56
RefSeq

4
UniProt

5
CCDS

CCDS17286.1

Ensembl

ENSMUSG00000027706 (Evidence)
NCBI Gene

69276

			Length	Strain/Species	Flank
genomic	69276	NCBI Gene Model \| MGI Sequence Detail	28388	C57BL/6J	± kb
transcript	NM_027016	RefSeq \| MGI Sequence Detail	3966	C57BL/6
polypeptide	Q8BU14	UniProt \| EBI \| MGI Sequence Detail	398	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000014599 translocation protein SEC62

(term hierarchy)
InterPro Domains

IPR004728 Translocation protein Sec62

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All nucleic 15

cDNA 15

Microarray probesets 10

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MGI:2139808, MGI:2139994

Summaries

All 38

Developmental Gene Expression 1

Diseases 1

Gene Ontology 5

Phenotypes 11
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Sec62:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr28687	Chr3:30846049-30846052 (+)	-974 bp
Tssr28688	Chr3:30847182-30847216 (+)	174 bp
Tssr28689	Chr3:30847230-30847247 (+)	214 bp
Tssr28690	Chr3:30847277-30847296 (+)	262 bp
Tssr28691	Chr3:30847450-30847502 (+)	451 bp
Tssr28692	Chr3:30855242-30855254 (+)	8,223 bp
Tssr28693	Chr3:30855260-30855277 (+)	8,244 bp
Tssr28694	Chr3:30863966-30864009 (+)	16,963 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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