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Lrrc46 Gene Detail
Summary
  • Symbol
    Lrrc46
  • Name
    leucine rich repeat containing 46
  • Synonyms
    1700006D24Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916547
    NCBI Gene: 69297
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:96925428-96932195 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 60.65 cM, cytoband D
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    288 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916547
 protein coding gene Chr11:96925428-96932233 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019021
 protein coding gene Chr11:99412366-99419860 (-)
A/J MGP_AJ_G0018989
 protein coding gene Chr11:95343417-95350615 (-)
AKR/J MGP_AKRJ_G0018959
 protein coding gene Chr11:98299735-98306613 (-)
BALB/cJ MGP_BALBcJ_G0018962
 protein coding gene Chr11:95831523-95839639 (-)
C3H/HeJ MGP_C3HHeJ_G0018776
 protein coding gene Chr11:98410080-98417837 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019414
 protein coding gene Chr11:102496502-102503297 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017045
 protein coding gene Chr11:92805733-92812323 (-)
CAST/EiJ MGP_CASTEiJ_G0018329
 protein coding gene Chr11:99265206-99272042 (-)
CBA/J MGP_CBAJ_G0018747
 protein coding gene Chr11:106704921-106715605 (-)
DBA/2J MGP_DBA2J_G0018855
 protein coding gene Chr11:94894555-94901223 (-)
FVB/NJ MGP_FVBNJ_G0018844
 protein coding gene Chr11:94371563-94379995 (-)
LP/J MGP_LPJ_G0018925
 protein coding gene Chr11:99940683-99947476 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018871
 protein coding gene Chr11:106627093-106633879 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019454
 protein coding gene Chr11:98594240-98600889 (-)
PWK/PhJ MGP_PWKPhJ_G0018101
 protein coding gene Chr11:95865801-95873926 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017891
 protein coding gene Chr11:98316796-98325803 (-)
WSB/EiJ MGP_WSBEiJ_G0018379
 protein coding gene Chr11:98500016-98506671 (-)



Homology
more
  • Human Ortholog
    LRRC46, leucine rich repeat containing 46
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LRRC46, leucine rich repeat containing 46
  • Links
    NCBI Gene ID: 90506
    neXtProt AC: NX_Q96FV0
    UniProt: Q96FV0

  • Chr Location
    17q21.32; chr17:47831634-47837719 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mice for a null allele exhibit male infertility. Males have reduced total sperm counts, impaired sperm motility, and spermiogenesis defects resulting in abnormal sperm flagella and heads.
Gene Ontology
(GO)
Classifications
less
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

Cellular Component
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    754
  • Tissues
    4
  • cDNA Data
    25
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 69297 NCBI Gene Model | MGI Sequence Detail 6768 C57BL/6J ±  kb
    transcript NM_027026 RefSeq | MGI Sequence Detail 1338 Not Specified  
    polypeptide Q9DAP0 UniProt | EBI | MGI Sequence Detail 323 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 25
      cDNA 25

      Microarray probesets 2
    References
    more
    • Summaries
      All 29
      Developmental Gene Expression 2
      Phenotypes 10
    • Earliest
      J:56548 Zheng B, et al., Engineering a mouse balancer chromosome. Nat Genet. 1999 Aug;22(4):375-8
    • Latest
      J:330199 Yin Y, et al., LRRC46 Accumulates at the Midpiece of Sperm Flagella and Is Essential for Spermiogenesis and Male Fertility in Mouse. Int J Mol Sci. 2022 Jul 31;23(15)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory