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Pacrg Gene Detail
Summary
  • Symbol
    Pacrg
  • Name
    PARK2 co-regulated
  • Synonyms
    1700008H23Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916560
    NCBI Gene: 69310
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:10621938-11059078 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 7.80 cM, cytoband A2
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    9765 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916560
 protein coding gene Chr17:10621938-11059198 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023141
 protein coding gene Chr17:8002386-8446119 (-)
A/J MGP_AJ_G0023109
 protein coding gene Chr17:7900263-8347753 (-)
AKR/J MGP_AKRJ_G0023073
 protein coding gene Chr17:7641296-8107605 (-)
BALB/cJ MGP_BALBcJ_G0023109
 protein coding gene Chr17:7684052-8127623 (-)
C3H/HeJ MGP_C3HHeJ_G0022872
 protein coding gene Chr17:7929828-8378560 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023552
 protein coding gene Chr17:8307512-8776892 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021056
 protein coding gene Chr17:6068028-6515260 (+)
CAST/EiJ MGP_CASTEiJ_G0022386
 protein coding gene Chr17:7957829-8415692 (-)
CBA/J MGP_CBAJ_G0022844
 protein coding gene Chr17:8626859-9113345 (-)
DBA/2J MGP_DBA2J_G0022977
 protein coding gene Chr17:7541087-7986185 (-)
FVB/NJ MGP_FVBNJ_G0022947
 protein coding gene Chr17:7497296-7935840 (-)
LP/J MGP_LPJ_G0023049
 protein coding gene Chr17:7782948-8241294 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022966
 protein coding gene Chr17:8297924-8777109 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023578
 protein coding gene Chr17:7948705-8396508 (-)
PWK/PhJ MGP_PWKPhJ_G0022134
 protein coding gene Chr17:7232456-7678406 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021964
 protein coding gene Chr17:7294747-7749031 (-)
WSB/EiJ MGP_WSBEiJ_G0022443
 protein coding gene Chr17:8251775-8707552 (-)



Homology
more
  • Human Ortholog
    PACRG, parkin coregulated
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PACRG, parkin coregulated
  • Synonyms
    BUG21, GLUP, HAK005771, PACRG2.1, PARK2CRG, pf12
  • Links
    NCBI Gene ID: 135138
    neXtProt AC: NX_Q96M98
    UniProt: Q96M98

  • Chr Location
    6q26; chr6:162727132-163315500 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    108 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Along with altered levele of the Qki transcript, both Pacrg and Park2 are inactivated as a result of a 1.85 Mb deletion in the in the quaking mouse. The quaking mouse is a spontaneous dysmyelinating mutant that demonstrates abnormal locomotion, tremor, tonic-clonic seizures, and reduced male fertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    43
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    780
  • Tissues
    16
  • cDNA Data
    21
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 69310 NCBI Gene Model | MGI Sequence Detail 437141 C57BL/6J ±  kb
    transcript NM_027032 RefSeq | MGI Sequence Detail 1355 ZRU/MplStud  
    polypeptide Q9DAK2 UniProt | EBI | MGI Sequence Detail 241 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 25
      Genomic 3
      cDNA 21
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 147
      Developmental Gene Expression 4
      Gene Ontology 13
      Phenotypes 108
    • Earliest
      J:13141 SIDMAN RL, et al., MUTANT MICE (QUAKING AND JIMPY) WITH DEFICIENT MYELINATION IN THE CENTRAL NERVOUS SYSTEM. Science. 1964 Apr 17;144:309-11
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory