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Necab1 Gene Detail
Summary
  • Symbol
    Necab1
  • Name
    N-terminal EF-hand calcium binding protein 1
  • Synonyms
    1700003H21Rik, Efcbp1, NECAB1, STIP-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916602
    NCBI Gene: 69352
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:14952245-15149794 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 6.45 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    5348 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916602
 protein coding gene Chr4:14952245-15149804 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028070
 protein coding gene Chr4:11776153-11977387 (-)
A/J MGP_AJ_G0028028
 protein coding gene Chr4:11495227-11697720 (-)
AKR/J MGP_AKRJ_G0027993
 protein coding gene Chr4:11679762-11888184 (-)
BALB/cJ MGP_BALBcJ_G0028039
 protein coding gene Chr4:11416863-11627021 (-)
C3H/HeJ MGP_C3HHeJ_G0027769
 protein coding gene Chr4:11844743-12035982 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028482
 protein coding gene Chr4:12303191-12521575 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025824
 protein coding gene Chr4:10749014-10926573 (-)
CAST/EiJ MGP_CASTEiJ_G0027224
 protein coding gene Chr4:11641672-11834010 (-)
CBA/J MGP_CBAJ_G0027742
 protein coding gene Chr4:12548766-12757896 (-)
DBA/2J MGP_DBA2J_G0027885
 protein coding gene Chr4:11365859-11552202 (-)
FVB/NJ MGP_FVBNJ_G0027851
 protein coding gene Chr4:11138357-11320171 (-)
LP/J MGP_LPJ_G0027994
 protein coding gene Chr4:11885786-12087535 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027884
 protein coding gene Chr4:12911684-13114964 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028541
 protein coding gene Chr4:11688212-11889677 (-)
PWK/PhJ MGP_PWKPhJ_G0026944
 protein coding gene Chr4:11317091-11504787 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026773
 protein coding gene Chr4:11562331-11756155 (-)
WSB/EiJ MGP_WSBEiJ_G0027301
 protein coding gene Chr4:11717207-11909154 (-)



Homology
more
  • Human Ortholog
    NECAB1, N-terminal EF-hand calcium binding protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NECAB1, N-terminal EF-hand calcium binding protein 1
  • Synonyms
    EFCBP1, STIP-1
  • Links
    NCBI Gene ID: 64168
    neXtProt AC: NX_Q8N987
    UniProt: Q8N987

  • Chr Location
    8q21.3; chr8:90791741-90959393 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    712
  • Tissues
    6
  • cDNA Data
    11
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000040536 Ensembl Gene Model | MGI Sequence Detail 197550 C57BL/6J ±  kb
transcript ENSMUST00000041606 Ensembl | MGI Sequence Detail 4922 Not Applicable  
polypeptide ENSMUSP00000038165 Ensembl | MGI Sequence Detail 352 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 12
    cDNA 11
    Primer pair 1

    Microarray probesets 2
References
more
  • Summaries
    All 31
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 7
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:343048 Udagawa H, et al., Glucocorticoid receptor-NECAB1 axis can negatively regulate insulin secretion in pancreatic beta-cells. Sci Rep. 2023 Oct 20;13(1):17958
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory