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Creb3l4 Gene Detail
Summary
  • Symbol
    Creb3l4
  • Name
    cAMP responsive element binding protein 3-like 4
  • Synonyms
    1700012K17Rik, 5330432F22Rik, ATCE1, JAL, mJAL, Tisp40, Tisp40alpha, Tisp40beta
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916603
    NCBI Gene: 78284
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:90144807-90150819 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 39.21 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    231 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916603
 protein coding gene Chr3:90144805-90161387 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027458
 protein coding gene Chr3:90527710-90533722 (-)
A/J MGP_AJ_G0027422
 protein coding gene Chr3:87518796-87525560 (-)
AKR/J MGP_AKRJ_G0027386
 protein coding gene Chr3:89667566-89673578 (-)
BALB/cJ MGP_BALBcJ_G0027431
 protein coding gene Chr3:87479419-87485433 (-)
C3H/HeJ MGP_C3HHeJ_G0027173
 protein coding gene Chr3:89834291-89840303 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027877
 protein coding gene Chr3:93937948-93943960 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025229
 protein coding gene Chr3:83017481-83023517 (-)
CAST/EiJ MGP_CASTEiJ_G0026619
 protein coding gene Chr3:90215977-90222842 (-)
CBA/J MGP_CBAJ_G0027147
 protein coding gene Chr3:97175785-97181797 (-)
DBA/2J MGP_DBA2J_G0027285
 protein coding gene Chr3:86890997-86897011 (-)
FVB/NJ MGP_FVBNJ_G0027253
 protein coding gene Chr3:85227999-85234011 (-)
LP/J MGP_LPJ_G0027394
 protein coding gene Chr3:91599487-91605327 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027273
 protein coding gene Chr3:103365226-103371342 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027936
 protein coding gene Chr3:89420828-89426842 (-)
PWK/PhJ MGP_PWKPhJ_G0026353
 protein coding gene Chr3:86777354-86783340 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026172
 protein coding gene Chr3:88595065-88601116 (-)
WSB/EiJ MGP_WSBEiJ_G0026701
 protein coding gene Chr3:89811126-89816974 (-)



Homology
more
  • Human Ortholog
    CREB3L4, cAMP responsive element binding protein 3 like 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CREB3L4, cAMP responsive element binding protein 3 like 4
  • Synonyms
    AIBZIP, ATCE1, CREB3, CREB4, hJAL, JAL
  • Links
    NCBI Gene ID: 148327
    neXtProt AC: NX_Q8TEY5
    UniProt: Q8TEY5

  • Chr Location
    1q21.3; chr1:153967487-153974361 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display oligozoospermia but have normal fertility and sperm morphology and motility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    975
  • Tissues
    200
  • cDNA Data
    33
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027938 Ensembl Gene Model | MGI Sequence Detail 6013 C57BL/6J ±  kb
    transcript ENSMUST00000029547 Ensembl | MGI Sequence Detail 1553 Not Applicable  
    polypeptide ENSMUSP00000029547 Ensembl | MGI Sequence Detail 370 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000005859 cyclic AMP-responsive element-binding protein 3-like protein 4
      (term hierarchy)
    • InterPro Domains
      IPR004827 Basic-leucine zipper domain
      IPR046347 Basic-leucine zipper domain superfamily
      IPR051381 cAMP-responsive element-binding ATF subfamily
    • GlyGen
      Q9D2A5 2 sites
    Molecular
    Reagents
    less
    • All nucleic 38
      cDNA 34
      Primer pair 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1925534, MGI:2139929, MGI:2139944
    References
    more
    • Summaries
      All 58
      Developmental Gene Expression 9
      Diseases 1
      Gene Ontology 8
      Phenotypes 17
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:341024 Zhang X, et al., Tisp40 prevents cardiac ischemia/reperfusion injury through the hexosamine biosynthetic pathway in male mice. Nat Commun. 2023 Jun 8;14(1):3383
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory